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Biomedical subjects

T Herskovic

Publications and source records attributed to T Herskovic.

At least 19 recordsLinked to original sources
PubMed1979

Radiation dose to the eyes using a "German helmet" field with the 4-MV linear accelerator.

A "German helmet" field defined by depleted uranium or Asarcola blocks was used to reduce the dose to the lens. With the uranium blocks, the lenticular dose was reduced to about 60% of the central axis dose (CAD). The Asarcola blocks reduced the lenticular dose to about 43% of the CAD. Even further reduction (15% CAD) was achieved by tilting the gantry 5 degrees or 10 degrees.

Eye↗
PubMed1969

Effects of neomycin and penicillin administration on mucosal proliferation of the mouse small intestine. With morphological and functional correlations.

The effects of an oral neomycin and penicillin regimen on intestinal bacteriology and on morphology and function of the small intestine of mice were investigated. Quantitative and qualitative stool cultures on selective media of the treated animals revealed only growth of yeast organisms. The treated animals developed enlargement of the ceca with fluid contents and watery stools, resembling characteristics of germfree animals. Radioautography with tritiated thymidine revealed an increased epithelial cell migration rate in the mice treated with the antibiotics for 3 to 5 wk. A slight increase in villus height was also noted. The treated male mice showed greater variance than the treated females in epithelial cell migration rates. Histochemical staining reactions showed a decrease in nonspecific esterase and in NADH dehydrogenase activity in the proximal gut of the antibiotic animals. Stains of distal gut and those for acid and alkaline phosphatase, NADPH dehydrogenase, lactic dehydrogenase, and succinic dehydrogenase were similar to the controls. A slight increase in sucrase activity and a slight decrease in lactase activity in the antibiotic animals was observed in contrast to control animals. Germfree mice, however, had greater sucrase and lactase activity. Transport of L-methionine was slightly reduced in the distal segment of the treated animals. Since the direction of these changes is away from the intestinal state observed in germfree animals, they are probably the result of the direct action of the antibiotics on the gut.

Animals↗