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Biomedical subjects

T Hirose

Publications and source records attributed to T Hirose.

980 records · Page 55Linked to original sources
PubMedDate not supplied

Malignant peripheral nerve sheath tumor of the pancreas with perineurial cell differentiation.

The authors report a malignant peripheral nerve sheath tumor (MPNST) that developed in the body of the pancreas of a 76-year-old woman. The well-demarcated tumor, 4.5 x 3.5 cm in size, was composed of spindle-shaped cells arranged in a storiform pattern or sweeping fascicles. Ultrastructurally, the tumor cells had elongated cytoplasmic processes with numerous pinocytotic vesicles, and were covered with discontinuous basal lamina-like substances. Immunohistochemically, tumor cells were diffusely positive for epithelial membrane antigen, vimentin, and CD34, but negative for S-100 protein and Leu 7. It was therefore concluded that the tumor was a MPNST with perineurial cell differentiation. Primary MPNST of the pancreas is extremely rare and the immunohistochemical and ultrastructural studies are necessary for its diagnosis.

Aged↗
PubMedDate not supplied

Visual hand display (VHD) as an introductory procedure for measuring vision in infants and young children with visual impairment.

We developed the Visual Hand Display (VHD) to measure vision in visually impaired infants and young children. The VHD is a circular fabric mitten, which is held easily by inserting the hand between the two surfaces. Black-and-white stripes are attached to one surface, 25, 15, 10, 4, and 2 mm per stripe. The VHD acuity is determined by the shortest test distance and the smallest stripes that the patient can detect. The VHD acuities were compared with preferential looking (PL) staircase acuities in 130 patients (53 males, 77 females; age range, 2 to 13 years; median, 21.0 months). Of these, 107 (82.3%) had various degrees of retinopathy of prematurity. The correlation between the VHD and the PL acuities was high (R2 = 0.849). PL acuities were better than the VHD acuities in 98/130 patients (75.4%), with an average difference of 0.51 (SD = 0.70) octave. The visual acuity differences were more pronounced in subjects with slight visual impairment and much less in subjects with severe visual impairment. The VHD seems to be an effective introductory method to evaluate visual acuity in severely visually impaired infants and young children. This method also would be effective with severely mentally and physically disabled patients who cannot undergo PL testing.

Adolescent↗
PubMedDate not supplied

Tonometry in pediatric patients: a comparative study among Tono-pen, Perkins, and Schiötz tonometers.

Measuring the intraocular pressure (IOP) in children can be difficult. We compared the accuracy of IOP measurements in pediatric patients using three tonometers: Perkins, Schiötz, and Tono-pen. Seventy-seven children (132 eyes; average age, 1 year, 7 months; range, 1 month to 60 months), mainly afflicted with retinopathy of prematurity (107 eyes), were evaluated. A good correlation (r = 0.867) was found between the Tono-pen and the Perkins tonometers. No statistical difference was found between the mean difference of IOP values obtained with the Tono-pen and the Perkins (P > .05). The Schiötz measurements were significantly higher than those obtained with the Perkins and the Tono-pen tonometers (P < .05). We concluded that the Tono-pen tonometer has a higher correlation coefficient, comparable to the Perkins tonometer, and can be used reliably to assess IOP in pediatric patients.

Aging↗
PubMedDate not supplied

Vinca alkaloids induce granulocyte-macrophage colony stimulating factor in human peripheral blood mononuclear cells.

Several anti-cancer drugs are known to have proliferation-related effects on various cells, such as an activation of some transcription factors and an induction of some cytokines. We examined the effect of anti-cancer drugs on granulocyte-macrophage colony stimulating factor (GM-CSF) induction in human peripheral blood mononuclear cells (PBMC). Increase of GM-CSF protein and mRNA were observed in PBMC after exposure to vindesine sulfate (VDS). Induction of GM-CSF protein was dose-dependent and detectable at VDS concentrations of 0.1 microgram/ml. This effect was also observed in response to treatment with other microtuble-depolymerizing agents, vincristine sulfate and vinorelbine ditartrate, but not with cisplatin, etoposide, or paclitaxel. In order to elucidate the mechanism of this phenomenon, we examined the effects of cyclohexamide and actinomycin D on the expression of GM-CSF mRNA. Both of these drugs completely inhibited GM-CSF mRNA expression after VDS exposure, implying that VDS induces de novo GM-CSF synthesis in an indirect manner. As a candidate for the initial signaling, we next examined the role of the IL-1 beta autocrine or paracrine pathways in GM-CSF induction by VDS. IL-1 beta protein and mRNA expression were induced after VDS exposure more rapidly (from 4 hours) than expression of GM-CSF (protein from 12 hours and mRNA from 8 hours). Addition of anti-IL-1 beta antibody partially inhibited induction of GM-CSF by VDS. These results suggest that GM-CSF induction by VDS is partially mediated through the initial generation of IL-1 beta in PBMC.

Antineoplastic Agents, Phytogenic↗
PubMedDate not supplied

Pars plana virectomy. Preoperative evaluation.

We have outlined the essential considerations in evaluating patients for closed vitrectomy and have attempted to show the importance of each. In general, we recommend closed virectomy under the following conditions: (1) vitreous opacities showing no resolution after six months of observation, (2) vision which is worse than 20/200 but has at least light perception with accurate projection, (3) there is no rubeosis iridis or glaucoma, (4) ultrasonography, ERG, and VER reveal a functional retina and optic nerve, and (5) the benefit outweighs the risk of surgery.

Electroencephalography↗