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Biomedical subjects

T Hiroshi

Publications and source records attributed to T Hiroshi.

5 recordsLinked to original sources
PubMed1998

The application of model-based complexity inference method to molecular evolution analysis.

In this study, a new method based on the concept of complexity in inductive inference is proposed for reconstructing molecular phylogenetic tree. This method describes the complexity of molecular phylogenetic tree by three terms, which are related to tree topology, the branch lengths and fitness between the model and data measured by likelihood function. The computer simulation is used to investigate the efficiency of this method. The results suggest that this method is superior to the traditional methods because it avoids excess-complexity in the tree model estimation available from DNA sequence.

Base Sequence↗
PubMed1996

[Xenotransplantation].

A Bulk of studies on xenotransplantation have been accumulated for the last few years. Most of the studies focus in the investigation for etiologic mechanism of hyperacute rejection seen in the xenotransplantation between distant species. Underlying pathophysiology in hyperacute rejection is primarily based on initial antigen-antibody reaction between oligosaccharide epitope of the xenogeneic organ and natural antibody in the recipient plasma. Subsequent activation of complement cascade and activation of the endothelial cell constitute an integral part of the entire complexity of the hyperacute rejection. We herein summarize the updated knowledge and provide an overview on this interesting research field.

Animals↗
PubMed1994

[Effects of monoclonal antibodies on phagocytosis of Entamoeba histolytica to human erythrocytes].

Two monoclonal antibodies 3F7 and 4G6 were produced respectively against plasma membrane and nucleus-cytoplasm of Entamoeba histolytica. The erythrocytophagous quantification and ability of pathogenic strain HM-1:IMSS were evaluated by microscopy immediately at 5 min and 10 min after incubation with McAb 3F7 and McAb 4G6. Sera from normal mice and monoclonal antibody TCE 04 against Trypanosoma cruzi were prepared as negative controls. The McAb 3F7 showed stronger inhibitory action on the erythrocytophagous effect of HM-1:IMSS than the McAb 4G6. The result suggested a significant inhibition (P < 0.001) on erythrocytophagous effect of amoebic trophozoites in the presence of McAb 3F7. This inhibitory action appeared to have a decreasing tendency with the elapse of incubation time.

Animals↗
PubMed1989

[Infectious diseases in kidney transplant recipients treated with cyclosporin].

Cyclosporin (CYA) is now recognized as an effective immunosuppressant to lead to a marked improvement in graft survival in organ transplant recipients. Although the incidence of infection in the CYA group has been decreased compared with that in the azathioprine group, infectious diseases in 400 kidney transplant recipients treated with CYA were noted in our single center. Treatment strategy for infectious diseases: Antibiotics and/or gamma-Globulin were administered to all recipients with bacterial infections. Aciclovir was added in recipients with herpes simplex virus (HSV) infection or varicella zoster virus (VZV) infection. Human interferon-beta (HuIFN-beta) was used in recipients who had life-threatening viral infection, especially cytomegalovirus (CMV) pneumonitis. Glycyrrhizin was used for acute hemorrhagic cystitis and nephropathy due to adenovirus (AV). Trimethoprim sulfamethoxazole and/or pentamidine were added in recipients complicated with Pneumocystis carinii (Pc) pneumonitis or in order to prevent Pc pneumonitis. Infectious diseases: One hundred and six recipients had infectious diseases 129 times in this series, seventy-six percent of all infections occurred during the first 4 months after the transplantation. Urinary tract infection (UTI), herpes zoster and pulmonary infection were the most common infectious diseases, occurring in 28.7%, 24.0% and 23.2%, respectively. Septicemia or bacteremia developed in 9 recipients, secondary to UTI in 8 and to surgical wound infection in one. Sixty-one symptomatic viral infections occurred in 57 recipients. A total of 5 recipients (1.3%) died of interstitial pneumonitis. Infectious organisms: Viral and bacterial infections were most common, occurring in 47.3% and 41.9%, respectively. Viral species detected in these recipients with the frequency were HSV 14 times, CMV 9 times, VZV 31 times and AV 7 times. 1) The incidence of viral infections in kidney transplant recipients treated with CYA is relatively high compared to bacterial infections. 2) HuIFN-beta therapy is effective in the treatment of serious opportunistic herpes virus infections, especially CMV pneumonitis. 3) Glycyrrhizin therapy is effective in the treatment of acute hemorrhagic cystitis and nephropathy due to AV and hepatic dysfunction. 4) Aerosolised pentamidine therapy is very useful for prophylaxis of Pc pneumonitis.

Adolescent↗