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T Hirsch

Publications and source records attributed to T Hirsch.

65 records · Page 4Linked to original sources
PubMed1990

Monoclonal antibodies against antigens expressed by human sperm.

The production and characterization of 21 mouse monoclonal antibodies (TüS1-TüS21) with specificity predominantly for human spermatozoa antigens is described. Reactivity of cells from human ejaculates, peripheral blood and several organs was determined using the alkaline phosphatase-anti-alkaline phosphatase (APAAP)-technique as well as the indirect immunofluorescence test. 15 of the monoclonal antibodies reacted with various regions of human sperm and often also with their precursor cells in the testis. Cross-reactivity with animal spermatozoa was frequently observed.

Acrosome↗
PubMed1990

[Sperm detection using monoclonal antibodies].

Monoclonal antibodies against sperm antigens detect specifically seminal stains in forensic casework. Different monoclonal antibodies resulting from the hybridoma technique allow by means of peroxidase test-system a direct marking of the trace.

Antibodies, Monoclonal↗
PubMed1989

The use of oral hydration in the treatment of children with acute diarrhea in primary care.

The use of oral rehydration solutions (ORSs) for treating children with diarrhea is spreading in hospitals in Chile, but it has not yet been incorporated into routine primary care programs. We sequentially compared the effectiveness of an ORS, with 60 mmol/L of Na+, with the standard treatment for diarrhea used in primary care centers, in a study with 285 diarrheal children under 2 years of age who consulted a health center in a low-income periurban neighborhood of Santiago. When compared with the control group, the patients treated with ORS showed a significantly higher percentage weight gain in the first few days after treatment was begun, required fewer medical visits for follow-up treatment at other facilities (8.4 vs. 15.5%; p less than 0.05), and experienced fewer episodes of subsequent clinical dehydration that needed rehydration (oral or intravenous) in emergency services (2.8 vs. 10.6%; p less than 0.01). In addition, there were no metabolic complications in either group. Our results reinforce the feasibility, efficaciousness, and safety of programs that use ORS at the primary care level and indicate that this is an effective method of preventing metabolic complications and reducing hospitalizations of children with acute diarrhea.

Chile↗
PubMedDate not supplied

The use of anti-asthmatic drugs in children: results of a community-based survey in Germany.

PURPOSE: To describe the use of anti-asthma drugs in children in the general population and in children with asthma using data from two large surveys in Germany. METHODS: Community-based random sample of 5-7 and 9-11-year-old children in Dresden and Munich were studied in 1995/96 by parental questionnaires using the Phase II protocol of the International Study of Asthma and Allergies in Childhood (ISAAC). A total of 11,094 children participated in the surveys (response rate 83%). RESULTS: In all children, inhaled beta 2-agonists were used most frequently during the last 12 months (2.6%), followed by inhaled cromolyns (2.5%), oral beta 2-agonists (1.5%), and inhaled steroids (0.9%). Drug use was significantly higher among boys than girls and in older children compared to younger ones (P < 0.05 for both). Among children with current asthma, 47% had used inhaled beta 2-agonists, 43% inhaled cromolyns, 22% oral beta 2-agonists, and 16% inhaled steroids. Inhaled steroids were used significantly more often in Dresden (21.7%) than in Munich (11.2%) (P < 0.05). CONCLUSIONS: Among anti-asthma drugs, agents used for symptomatic relief were the most frequently reported followed by inhaled anti-inflammatory agents. Most of the anti-inflammatory drugs used were SCG, which may indicate under-treatment with inhaled steroids.

Adrenergic beta-Agonists↗
PubMedDate not supplied

Indoor allergen exposure in west and East Germany: a cause for different prevalences of asthma and atopy?

West and East Germans have been living in two different political systems for 40 years. These two populations have become a classic epidemiological example for the hypothesis that lifestyle changes accompanying the industrial and economic development of modern societies are responsible for an increase in the prevalence of atopic diseases. A higher prevalence of atopic sensitization, asthma, and hay fever was found in young West Germans after the unification. It has been hypothesized that this phenomenon was at least partially due to the installation of insulating windows and central heating systems in Western homes, favoring the growth of microorganisms like mites and moulds and increasing indoor allergen exposure. This review summarizes studies that have investigated reservoir concentrations of indoor allergens in public buildings and private homes in East and West Germany. Whereas a higher prevalence of atopic sensitization in West Germans was found for nearly all tested allergens (cat, mite, pollen), allergen exposure was higher only for cat allergens, but probably not for mite and cockroach allergens or moulds. The published data do not support the view that the differences in specific sensitization are caused by differences in the exposure to specific allergens.

Adolescent↗
PubMedDate not supplied

[Haemophilus influenzae B meningitis and Waterhouse-Friderichsen syndrome in a 5-month-old infant].

A five months old infant with Waterhouse-Friderichsen syndrome related to Haemophilus influenzae type b meningitis is reported. In spite of treatment with IV fluids, antibiotics and dopamine, he died eight hours after admission. Necropsy findings included bilateral adrenal bleeding compatible with the Waterhouse-Friderichsen syndrome. This is the younger infant reported with this diagnosis in association with Haemophilus influenzae in Chile.

Humans↗