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Biomedical subjects

T Hodges

Publications and source records attributed to T Hodges.

8 recordsLinked to original sources

Mycobacterium marinum infection in a lung transplant recipient.

We report a case of Mycobacterium marinum infection in a lung transplant recipient who presented with nodules on the hand and forearm following exposure to fish-tank water of a superficial hand burn. Skin biopsy revealed granulomatous inflammation and fibrosis. Tissue culture grew Mycobacterium marinum. The patient underwent surgical excision of the lesions and treatment with ethambutol and azithromycin for 12 months and experienced complete resolution of the infection. Transplant recipients who receive immunosuppressive therapy are at increased risk for opportunistic infections. For a patient with nodular lesions on the extremities, exposure to fish, fish-tank water, or swimming should suggest infection with Mycobacterium marinum.

Female↗

Earth benefits of interdisciplinary CELSS-related research by the NSCORT in Bioregenerative Life Support.

Earth benefits of research from the NSCORT in Bioregenerative Life Support will include the following: development of active control mechanisms for light, CO2, and temperature to maximize photosynthesis of crop plants during important phases of crop development; automation of crop culture systems; creation of novel culture systems for optimum productivity; creation of value-added crops with superior nutritional, yield, and waste-process characteristics; environmental control of food and toxicant composition of crops; new process technologies and novel food products for safe, nutritious, palatable vegetarian diets; creation of menus for healthful vegetarian diets with psychological acceptability; enzymatic procedures to degrade recalcitrant crop residues occurring in municipal waste; control-system strategies to ensure sustainabilty of a CELSS that will enable management of diverse complex systems on Earth.

Biomass↗

3D ultrasonic image feature localization based on magnetic scanhead tracking: in vitro calibration and validation.

The basis of a three-dimensional (3D) ultrasound imaging system was constructed from a commercially available magnetometer-based position and orientation measurement (POM) device, a standard B-Mode ultrasound instrument and a personal computer. To evaluate the system's performance, a novel method was devised using an iterative, least-squares technique to simultaneously determine the system's calibration parameters and measure its precision in locating points in three-dimensional space. When tested separately, the POM system located single points with a root mean squared (RMS) uncertainty of from 1.4 mm to 3.2 mm over the 610 mm working radius of the system. When combined with the ultrasound instrument, the RMS uncertainty in locating point targets varied from 2.1 mm to 3.5 mm. These results establish the lower limits of variability to be expected from this system when locating fiducial anatomical landmarks for repeated examinations of the same region of the body, and when making numerical 3D reconstructions from multiple planar images.

Calibration↗

Granular cell tumor of the eyelid.

We present a case of granular cell tumor of the eyelid. Although commonly reported elsewhere in the body, this entity rarely occurs in the ocular adnexa.

Adult↗

Neural spread of herpes simplex virus to the eye of the mouse: microbiological aspects and effect on the blink reflex.

This paper reports the microbiological aspects of zosteriform spread of herpes simplex virus (HSV) to the eye in the NIH strain of inbred mouse. Microbiological data support the concept of true zosteriform spread of herpes simplex virus from the inoculation site on the snout to the trigeminal ganglion, and thence to the eye. Following zosteriform spread of HSV to the eye, there is a frequent bacterial superinfection and this is associated with a typical clinical picture. Treatment of the mice with intensive systemic and topical antibiotics is able to alter the frequency with which this type of keratitis is seen.

Animals↗

The histology of the eye after zosteriform spread of herpes simplex virus in the mouse.

A murine model of zosteriform spread of herpes simplex virus to the eye is reported. Viral antigens were demonstrated by a peroxidase-antiperoxidase technique in the trigeminal ganglion, iris, ciliary body, and cornea. The histology suggested a spontaneous bacterial superinfection during the later stages of the herpetic disease of the cornea. The relevance to human disease is discussed.

Animals↗