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Biomedical subjects

T Horváth

Publications and source records attributed to T Horváth.

At least 19 recordsLinked to original sources
PubMed1992

[The place of percutaneous transluminal angioplasty in the treatment of obliterative vascular diseases of the lower limbs. Angioplasty of of the iliac system].

Between 1983-91 386 patients with hemodinamically significant stenosis or short-segment occlusion of iliac arteries were treated by transluminal angioplasty. 487 dilatations and 13 recanalizations were performed. In 353 (70.2%) of these cases were carried out without medicinal preparation continuously after the diagnostic angiography. The technical success rate was 93.4%. The technical success rate did not depend on medicinal preparation. 93% of their patients became symptomless or improved. 28 complications were noted (7 thrombosis, 4 embolisms, 14 inguinal haematomas, 2 false aneurysms, 1 bleeding), 11 of them required surgical intervention. One patient died because of cardiac failure due to retroperitoneal haematoma. Authors' opinion isolated short uni- and bilateral iliacal stenosis can be treated by transluminal angioplasty. Longer or multifocal stenosis required individual consideration.

Aneurysm↗
PubMed1992

[Treatment of pancreatic pseudocysts with ultrasound-guided percutaneous puncture and drainage].

The authors have treated 37 pancreatic pseudocysts in 36 patients by ultrasonically guided percutaneous puncture and drainage. The indication for intervention was rapid enlargement or threatening rupture of the acute (younger than 6-8 weeks) pseudocysts with recurring fever in 5 cases and chronic pseudocysts causing abdominal symptoms in 32 cases. After puncture six of seven patients were recuperated, but later in three of them the pseudocysts recurred. In one case as a complication of the puncture the pancreatitis exacerbated and led to death of the patient. The outcome of percutaneous drainage was successful in 26 of 32 pseudocysts. During the follow-up (6-54 months) recurrence were observed without symptoms in three cases. In four patients the treatment was ineffective, therefore cystogastrostomy was performed. During the time of the percutaneous drainage two pseudocysts had been infected and abscesses developed, which were treated by oncotomy. On the basis of their favourable experiences the authors recommend the US-guided percutaneous durable drainage as primer intervention for treatment of the pancreatic pseudocysts causing symptoms.

Aged↗
PubMed1992

Endogenous scavenger levels (vitamin E and A) of patients with chronic alcoholic liver disease under different environmental conditions.

Serum level of endogenous scavengers (E and A vitamin) was studied in groups of patients with various chronic alcoholic liver diseases and in a healthy control group on polluted and non-polluted areas. Vitamin levels in patients with chronic liver disease are diminished in comparison to the healthy in general, but mainly in the cirrhotic group. Diminution of vitamin E levels was observed in earlier phase of liver disease than that of vitamin A levels. Patients and healthy control on polluted area showed more expressed diminution of vitamin levels than the same groups on non-polluted area. Free radical parameter (RBC diene conjugate content) and characteristic alcoholic parameters (serum GOT, gamma-GT, cholesterol level and liver GOT, gamma-GT content in biopsy specimen) were used to explain the differences between the same investigated groups on polluted and non-polluted areas. As conclusion can be supposed that industrial pollution of environment has a worsening effect in diseases with free radical mechanism.

Cholesterol↗
PubMed1992

DNASK--a new image analysis module for TV image cytometry.

The DNASK is a PC-based image analysis module for quantitative cytological and histological examinations on Feulgen-Schiff preparations. The module consists of a frame grabber, a CCD black and white video camera and the DNASK software package which can be incorporated in an IBM compatible PC-AT joining to a standard pathological research photo microscope. The use of 386 IBM AT systems leads to significant decrease of the measurement's time. Mono- or color VGA graphics card should be used. The resolution of the images is 512 x 512 pixels and 256 gray values. The image caption is made in less than 0.5 second, the measurement of a cell nuclei (18 parameters) takes less, than 5 seconds (IBM AT 286). The camera is a standard CCD one. The microscope should be a good quality, modern microscope with built-in light source, however, the application of voltage stabiliser is strongly recommended. The software is able to measure the parameters mostly used and suggested in the international literature: 15 morpho- and densitometric parameters of the cell nuclei 6 DNA histogram parameters of the measured case, like DNA Index, 2c deviation Index, 5c exceeding rate, G1-S-G2 phase fraction ratio. The system supports the grouping of the measured cases and at the end of a study results of the single measurements can be collected and summarized in an ASCII file, which is readable by major statistical programpackages. The DNASK has a special graphical user interface for the control of the program.

Algorithms↗
PubMed1991

[Successful intraoperative angioplasty in bilateral fibromuscular dysplasia of the internal carotid arteries].

The authors report the clinical history of a 55-years old woman suffering from the multiplex stenosis of both internal carotid arteries caused by fibromuscular dysplasia. Successful intraoperative angioplasty was performed. In connection with their case the authors review briefly the clinical feature, diagnosis and therapy of fibromuscular dysplasia of the internal carotid artery.

Angioplasty, Balloon↗
PubMed1991

[Typhlitis as a complication of acute leukemia].

The authors describe the clinical history of two adult patients with acute myeloid leukemia, who had severe neutropenia and thrombocytopenia. After chemotherapy in both patients had developed typhlitis with fatal outcome caused by sepsis. They discuss the etiopathogenesis and clinical features of necrotizing typhlitis as a complication of treated acute leukemia and point out the difficulty of the differential diagnosis and management.

Adult↗
PubMed1990

[The role of intraoperative angioplasty performed simultaneously with reconstructive vascular surgery].

21 arterial lesions were dilated intraoperatively in conjunction with primary vascular reconstructive procedures. Of these, five involved the iliac vessels, fourteen the femoropopliteal segment, one the subclavian artery and one the common carotid artery. 19 intraoperative balloon dilatations were successful and two were unsuccessful. Only one catheter-related complication were noted, it was a perforation of the wall of the artery caused by guidewire. No deaths occurred as a result of the combined procedure. Attention is drawn to the advantage of the intraoperative balloon dilatation and the authors recommend it on adequate conditions and correct indication.

Adult↗
PubMed1990

[Reconstruction possibilities in obliterative arterial diseases in diabetics].

Authors treated 144 diabetic patients with arterial angiopathy localised to the lower extremities. 114 cases belonged to III. and IV. stages. There was a possibility in 55 (38.2 per cent) for reconstructive surgery, 80 per cent of the reconstructive procedures localised to the femoro-popliteal region. In 20 cases a so-called "high", in 61 a "low" (minor) amputation was performed, 14 patients died. In 113 cases (78.47 per cent) an improvement or a cure could have been achieved, of whom 52 with the complete preservation of the extremity, and in the others after necrectomy or minor amputation. Authors emphasize that, in more than a half of the cases the obstruction localised to the femoropopliteal and iliacal region, so the possibilities of the vascular surgery are given in a considerable number of diabetic patients.

Amputation, Surgical↗
PubMed1990

[Experience with the surgical treatment of superficial thrombophlebitis (varicophlebitis)].

107 patients with acute varicophlebitis of the lower limbs have been treated. In 101 cases operation were performed. These patients were treated by surgical excision of the thrombosed segments, with excision or stripping of the remaining varicosities and high saphena ligature. There were no postoperative deaths. One male patient experienced nonfatal minor pulmonary embolism. Wound-healing disturbances were observed in only 11 patients. Attention is drawn to the advantage of the surgical management. Regarding the good experiences, the authors recommend the performance of the "acute" varicectomy.

Humans↗
PubMed1989

[Management of malignant pleural effusion by tetracycline pleurodesis].

Eleven patients were treated with chest tube drainage and intrapleural instillation of tetracycline for malignant pleural effusion. In ten cases this procedure for 6-10 days achieved complete resolution of pleural fluid and produced pleurodesis. Only one patient needed longer treatment, but it was also successful. Fluid recurrence was not recognised during the follow-up period. This method is very effective and simple, so the authors recommend the tetracycline pleurodesis for the palliative management of malignant pleural effusions.

Breast Neoplasms↗
PubMed1989

Drug metabolism in drug-induced liver diseases: pathogenetic role of active metabolites.

Three cases with drug-induced liver diseases (hepatitis caused by hydralasine, steatosis caused by methimazole, choletasis caused by birth control pill) were investigated with respect to their drug metabolising ability. Clinical diagnoses were based on the exclusion of other pathogenetic factors, on histological findings of liver biopsy specimens and on the clinical chemical tests. Investigation of biotransforming ability was carried out using test materials (menthol loading, antipyrine, sulfadimidine, caffeine, indocyanine green kinetics) and measurement of D-glucaric acid excretion. In all cases the results show a defective capacity in some respect of drug metabolism. Possible pathogenetic role of reactive metabolites is discussed in the pathomechanism of genesis of drug-induced liver diseases.

Adult↗
PubMed1989

In vitro method for measurement of free radical effects: effect of PMS (phenazine methosulphate) on red blood cell membrane.

The aim of this study was to elaborate a simple in vitro model for rapid and quantitative measurement of free radical effects. Free radical generating characteristics of PMS were measured in the case of red blood cell (RBC) membrane. The mechanism of free radical action was investigated in MgCl2, CaCl2, BaCl2 and in Verapamil HCl medium. The most important result of the investigations is as follows: Membrane damage of RBC provoked by the mechanism of free radical generation of PMS is proportional to the intracellular K+-efflux and to the extracellular Na+-influx. The PMS dependent K+-efflux in a NaCl containing medium in the presence of CaCl2 increases significantly, while it remains unchanged in MgCl2 medium. The PMS dependent K+-efflux and Na+-influx were considerably decreased by Verapamil HCl in NaCl containing solution. We have come to the conclusion that new, non-selective pores are formed in the membrane. The measure of the damage increases in the presence of Ca2+ions and decreases in the medium containing Verapamil HCl.

Barium↗
PubMed1989

Alopecia areata and bisalbuminaemia (a casual coincidence).

Bisalbuminaemia, the heterozygote manifestation of an autosomal dominant condition, is detected by electrophoresis, when two distinct albumin bands are separated. Approximately 50 cases with bisalbuminaemia have been published worldwide. This phenomenon is very rare in Central Europe. A 17-year-old Hungarian girl, admitted for an alopecia areata of bacterial origin (tonsillitis), was found after routine electrophoresis to have bisalmbuminaemia. The albumin variant was of the "slow type". The ratio of the two components was 1:1. Immunoelectrophoresis with anti-albumin serum showed only one precipitation band in the albumin region. The rarity of bisalbuminaemia appeared to justify publication.

Adolescent↗
PubMed1987

Effects of allopurinol, (+)-cyanidanol-3 and dihydroquinoline-type antioxidants on rat hepatic microsomal cytochrome P-450 and monooxygenases.

The cytochrome P-450 system is a sensitive indicator in different forms of experimental liver diseases in the rat. Both CCl4 and ethanol produce a liver damage by free radical mechanisms causing a lesion of liver cell endoplasmic reticulum. Protective effects of antioxidants on CCl4 or ethanol induced liver damage were investigated on this basis in adult Wistar rats. The strongest protective effect in CCl4 treated animals was shown to be exerted by allopurinol. The other three antioxidants (cyanidanol, MTDQ monomer and MTDQ dimer) could not prevent the CCl4 induced changes, measured by liver/body mass quotient, P-450 concentration, ethylmorphine N-demethylation and ethoxycoumarin O-deethylation. Ethanol in the given doses did not produce any distinct effect on the test parameters. The most sensitive parameter was the ethylmorphine N-demethylation. In conclusion CCl4 intoxication is a suitable model for studying radical initiated liver injuries. The mechanisms of the hepatoprotective effects of the four substances are different.

Allopurinol↗
PubMed1986

Disorders of biotransformation during the progression of alcoholic liver disease.

Biotransformation capacity was investigated in patients with various degrees of alcoholic liver damage. Aim of the investigation was to study the impairment of biotransformating ability during progression of liver damage. Four groups of patients with various liver diseases (alcoholic fatty liver, chronic persistent hepatitis, chronic active hepatitis, alcoholic cirrhosis) and two groups as controls were studied. The investigations were carried out with exogenous test substances (antipyrine, menthol and sulphadimidine) and by determination of D-glucaric acid excretion. It has been concluded that the depression of biotransformating ability in patients with alcoholic liver diseases is progressing during development of diseases. The changes in various metabolic pathways are different, and they seem to be more marked in the first phase of biotransformation than in the second phases.

Biotransformation↗
PubMed1986

Beta-adrenoceptor blocking drugs and cytochrome P-450: the influence of propranolol treatment on caffeine, antipyrine, D-glucaric acid and indocyanine green elimination in patients with hepatic disorders.

The effect of the beta-adrenoceptor blocking drug propranolol was investigated in patients with alcoholic liver disease and in those without liver disease before and after ten days treatment with 80 mg daily. Caffeine as a marker drug for the 3-methylcholanthrene-inducible subtype had a significantly enhanced clearance after propranolol in liver-diseased patients, while the clearance of antipyrine which represents the phenobarbital-inducible subtype was unchanged. D-glucaric acid excretion as an endogenous compound which serves as an indicator of induced state of drug-metabolizing capacity of the liver was slightly enhanced in liver patients, but significantly decreased in patients without liver disorders. Indocyanine green elimination as a test material for substances limiting liver blood flow was not significantly reduced by this propranolol dosage.

Adult↗