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T Horvat

Publications and source records attributed to T Horvat.

16 recordsLinked to original sources
PubMed2005

Toxicity testing of herbicide norflurazon on an aquatic bioindicator species--the planarian Polycelis felina (Daly.).

Norflurazon is a bleaching, preemergence herbicide. Due to its mobility and long half-life it presents a potential for groundwater contamination. The aim of our study was to investigate toxic effects of norflurazon on non-targeted aquatic bioindicator organism, the planarian Polycelis felina (Daly.). Animals were exposed to water solutions of norflurazon in concentrations 200, 20, 2 and 0.2 microM. Mortality, locomotive and morphological changes were monitored. Histological changes were studied both on treated and control animals with light microscopy. The primary DNA damage on single planarian cells was studied using the alkaline comet assay. Three comet parameters were studied: tail length, percentage of DNA in comet tail and tail moment. The results showed that norflurazon caused mortality, locomotive, morphological and histological changes in treated animals compared to corresponding controls. The most prominent histological changes were damage of the outer mucous layer, lack of rhabdites, damage to epidermis and extensive damage to parenchyma cells. The results of alkaline comet assay indicated that norflurazon in concentrations of 2 and 0.2 microM induces significant increase of primary DNA damage in planarian cells compared to the corresponding control animals. The mean values of all three measured parameters were significantly elevated on the fourth day of the treatment compared with the first and the seventh day. Based on the results of mortality and locomotive observations, we conclude that the fourth day of the treatment represents a certain threshold within planarian metabolism followed by the beginning of detoxification and recovery. However, histological preparations and comet data statistics show results indicating that high toxicity on the seventh day of the treatment gave the results of decrease of DNA damage due to the tissue/cell damage (apoptosis) and not recovery. The present study showed the ability of norflurazon to induce a wide range of different toxicological responses in freshwater planarian Polycelis felina (Daly.).

Animals↗
PubMed1993

Therapeutic possibilities and limits in multiple primary carcinomas: consideration of 38 cases.

The authors report their experiences of 38 cases of multiple primary carcinomas, of which 17 were synchronous and 21 metachronous. Some of them were localized to the same organs and others on different organs. It is important that diagnosis be established in due time for the first and most of all, for the second or third tumour. Surgery by tumour exeresis constitutes the main treatment, being associated with radiotherapy and chemotherapy as adjuvants. The results recorded here may be considered to be quite good, since many patients reached 5 years of survival, both after the first and after the second operation. Thus, mean survival was 5.53 years in the 17 patients with synchronous carcinomas and more than 10 years in the 21 cases of metachronous carcinomas, i.e. 8.9 years after the first operation +4.05 years after the second operation with a 2.63 mortality rate.

Adult↗
PubMedDate not supplied

[Pulmonary aspergilloma successfully operated on in a patient with the pentalogy of Fallot].

Fallot disease occurs in 10% of congenital heart diseases. This case showed a clinical association between Fallot disease and a pulmonary aspergilloma. A 44-years male, with a history of Fallot disease (diagnosed in childhood) and a normal life, was admitted for repeated hemoptysis during last three months. Clinical examination revealed signs of Fallot disease: cyanosis, finger clubbing. CT scan and chest X-ray revealed a cavitary image in the right upper lobe. The CT image revealed a typical aspect of cavitary aspergilloma. The patient was referred to the thoracic surgeon, a right upper lobectomy was performed, which confirmed the presence of aspergilloma. Postoperative evolution was good.

Adult↗
PubMedDate not supplied

[Recurrent postoperative ulcer].

A total of 96 patients have been hospitalized over a period of 20 years, of which 89 had been operated for recidivating post-operative ulcer (RPOU). Particular clinical and etiopathogenic aspects are stressed, such as RPOU manifested exclusively by digestive haemorrhage, pseudo-tumoral RPOU, ulcers recidivating after exclusion resection, and multi-recidivating ulcers. Prophylaxis of RPOU is best achieved by a correct primary intervention for ulcers, and the prophylaxis of the recidives should be achieved by a correct re-intervention. This presumes that a correct resection, or a correct iterative resection should be performed, as well as a correct sub-diaphragmatic vagotomy. In recidivating post-operative ulcers on the duodenal stump an important element is the insufficiency of the resection on theright, and the value is stressed of an extended resection of the stump, associated to vagotomy. In multi-recidivating ulcers after repeated interventions that have been correctly performed, gastrectomy of the total type is considered the best solution.

Adult↗
PubMedDate not supplied

[Clinical study of the efficacy of albendazole treatment in human hydatidosis].

A follow-up study of Albendazol effectiveness therapy in human hydatid diseases was carry out using WHO methodology. Albendazole was given at a dose of 10 mg/Kg body/day in cycles of 28 days separated by 14 days without treatment. The efficacy of chemotherapy was evaluated by clinical improvement and changes in the cyst's morphology (detachment and collapse of the cyst membrane and increased density of the cyst fluid). We performed this study in 134 patients with hydatidosis: 17 patients with pre and post surgery treatment, 50 patients with post surgery treatment and 67 patients with chemotherapy only. Albendazole was effective in the hydatid disease; the patients with complex chemotherapy treatment did not report any secondary hydatidosis during the follow-up period (max. 2 years); the patients with exclusive chemotherapy reported 79% successful response, only 21% of them remained with unchanged cyst's size, but with modified internal structure. The therapeutic response depends of the cyst's size and its visceral site.

Adolescent↗
PubMedDate not supplied

[The chronology and diagnostic round of patients operated on for bronchopulmonary cancer].

UNLABELLED: 37 patients with certified diagnosis, operated for lung cancer (LC) in The Central Military Hospital Bucharest, during six months period (October 1st 1996-June 1st 1997). It was a retrospective study on the patients medical files. Sex distribution, postsurgical staging and histological type were studied. We calculated the following delays: 1. Between the first medical examination and the first suspicion (chest X-ray): 6 +/- 3 days; 2. Between the first medical examination and first hospital admission: 14 +/- 11 days; 3. Between the first hospital admission and the first admission in surgical units: 43 +/- 23 days; 4. Between the first admission in surgical units and surgery: 59 +/- 26 days; 5. The delay until bronchoscopy: 23 +/- 16 days; 6. The delay until the CT examination: 26 +/- 16 days; 7. Between the first medical examination and the surgery: 78 +/- 30 days. These delays were correlated with the specialty profile of the services which referred the patients: pulmonology, internal medicine, oncology or primary services. CONCLUSION: 1. Most patients come from pulmonology units (22 out of 37 patients); 2. There are significant delays until bronchoscopy and CT scan, the availability of these services is still limited; 3. The primary care medical network is still inefficient in early diagnosis of LC; 4. The overcrowding of thoracic surgery unit (scheduling for surgical intervention). All of these are arguments for developing more efficient and faster circuits of LC diagnosis, especially for high risk patients.

Adult↗