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T I Lukicheva

Publications and source records attributed to T I Lukicheva.

At least 19 recordsLinked to original sources
PubMed2002

[Comparison of determination methods and application of a computer program using a screening coordinate system to interpret hemoglobin A1c in patients with diabetes types 1 and 2].

The aim of the work is to compare methods of hemoglobin A1c determination in ratio with basic metabolism indices using computer program with graphic interpretation of results in patients with diabetes of 1 and 2 types. It was found out that more specific hemoglobin determination by isoelectrofocusing method more completely reflects the state of carbohydrate metabolism in diabetic patients. The importance of hemoglobin A1c determination in case of 2 type diabetes is particularly emphasized.

Adolescent↗
PubMed1998

[Clinical and diagnostic significance of microalbuminuria and activity of tubular enzyme N-acetyl-beta-D-glucosaminidase (NAG) determination in patients with hyperuricosuria].

AIM: Development of the approaches to detection of hyperuricosuric stage of purin metabolism derangement and specification of methods for early diagnosis of urate damage to the kidney. MATERIALS AND METHODS: The study included 115 young subjects whose parents suffer from gout with renal involvement or isolated urate nephropathy. Each patient was examined clinically with evaluation of family history for gout risk factors. Three times for 9 months measurements were made of uricemia and uricosuria, microalbuminuria and activity of tubular enzyme NAG. RESULTS: 45 (39.1%) patients had neither disturbances of purin metabolism nor renal affection. 70 (60.9%) patients had hyperuricosuria. In 23 (32.9%) of them microalbuminuria increased to > 20 mg/day, NAG activity to 5 u/l. Chronic tubulointerstitial nephritis was diagnosed in 17 (73.9%) patients. Six patients (26.1%) developed asymptomatic affection of the kidneys. The rest 47 patients had normal levels of microalbuminuria and NAG. There were 3 cases of hyperuricemia with microalbuminuria rising to 160-200 mg/day and further development of urinary syndrome. Hyperuricemia in them was registered at microalbuminuria higher that 160 mg/day. CONCLUSION: Microalbuminuria higher than 20 mg/day and NAG activity higher than 5 u/day are important diagnostic indicators of renal affection in hyperuricosuria including asymptomatic one. Microalbuminuria above 160 mg/day gives grounds to discuss the role of morphological changes prior to proteinuria.

Acetylglucosaminidase↗
PubMed1991

[The immunoturbidimetric determination of class G immunoglobulin using the FP-900 analyzer].

The immunoturbidimetric micromethod for measuring the blood serum IgG has been adapted to the FP-900 analytic system. Monospecific sera to IgG (H) manufactured by several institutions in this country were used in the study. The volumes of antiserum solvents were selected and the analytical reliability of the suggested micromethod assessed. Programs for introduction of the parameters for IgG measurements with FP-900 analyzer are presented.

Humans↗
PubMed1989

[Clinical evaluation of the Glucophot reflecting photometer in determining glucose in whole blood].

Clinical trials of the Glukofot reflecting photometer prototype for measuring the whole blood glucose in reagent strips have been carried out. The reproducibility has been assessed in various operations with different glucose concentrations. Attempts to estimate the calibration curve linearity and the accuracy with the control sera as against the glucose oxidase method have failed, probably because of the presence of stabilizers and inhibitors, and different viscosity of these substances as compared to whole blood viscosity. The rapid method has been compared to the universal methods and the neocuproin method for glucose measurements with the use of the AA autoanalyzer; the results obtained with these methods have coincided. The apparatus failures and approaches to improving its operation are discussed; it appears to be useful for blood glucose analysis in emergencies, at bedside, in ambulance cars, etc.

Adult↗
PubMed1988

[Two-dimensional parameter of the kinetics of glucose (rho-criterion) in the assessment of the efficacy and prognosis of therapy of diabetes mellitus].

The authors describe the results of i. v. GTT in 10 patients with diabetes mellitus before and after a course of hyperbaric oxygenation, in 5 of them the test was repeated. The results of the test were processed with the help of a new type of model of glucose kinetics based on the production of glucose by the liver and its elimination in the test. A new quantitative criterion (the so-called rho-criterion) of a degree of carbohydrate metabolic derangement was introduced for diabetic patients. Its calculation before and after a course of HBO permitted reliable quantitative assessment of the efficacy of sugar lowering therapy in such patients. The new method permitted the assessment of the production of glucose by the liver and the rate of its elimination in i.v. GTT. The mechanism of HBO-action was unraveled (the suppression of glucose production by the liver). Examples of 2 patients with type II diabetes mellitus have demonstrated the efficacy of the rho-criterion in the prediction of a sugar lowering effect of antidiabetic tablets in serious clinical situations.

Adult↗