[Nonpolyene macrolide antibiotics].
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Anti-Bacterial Agents↗
Biomedical subjects
T I Nikolaeva
Publications and source records attributed to T I Nikolaeva.
[beta-lactamase inhibitors].
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Anti-Bacterial Agents↗
[Study of the antigenic makeup of some producers of oxytetracycline using an immunoelectrophoretic method].
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Agar↗
[Self-assembly of collagen type I molecules without telopeptides].
The effect of temperature on the kinetics of formation of fibrils from rat tail collagen molecules devoid of telopeptides was studied. It was shown that the rats of fibril formation at 30 and 35 degrees C increases five- and eightfold, respectively, as compared with that at 25 degrees C. It was found that enthalpy of fibril denaturation at 30 degrees C is maximal for the collagen both with intact telopeptides and devoid of telopeptides. It was found that essential for the fibrilogenesis of type I collagen devoid of telopeptides are temperatures of 30 and 35 degrees C.
Animals↗
[Formation of collagen type I fibrils in vitro].
The assembly of collagen fibrils as a function of temperature and collagen concentration was studied. It was shown that temperature increases from 25 to 35 degrees C, the degree of ordering of collagen fibrils increases 1.5-fold at collagen concentration above 1 mg/ml and 2-fold at low collagen concentration. A maximum ordering of fibril structure occurs under conditions close to physiological (T approximately 35 degrees C and collagen concentration 1.2 mg/ml). As temperature is elevated from 30 to 35 degrees C, the packing of collagen molecules in fibrils becomes more ordered: the values of enthalpy and entropy of the transition of fibrils from the native to a disordered state decrease at all collagen concentrations used. At high collagen concentration, the dimensions of cooperative blocks in fibrils formed at 25 and 30 degrees C coincide with those of cooperative blocks of monomeric collagen in solution. Upon increasing the temperature to 35 degrees C, the dimensions of cooperative blocks increase.
Animals↗
[Results of the evaluation of a self-administered questionnaire in ophthalmology].
The suggested questionnaire in ophthalmology consists of 24 questions of case history and complaints with consideration for age. It was tried with 101 patients. The study has shown that premedical interview helps single out subjects with normal eyes, who have some complaints and therefore should be consulted by an ophthalmologist, and patients with impaired refraction, who should be consulted by an optometrist of ophthalmoergonomist; these groups have made up 10.9, 41.5, and 47.6 percent of those interviewed.
Diagnosis, Differential↗
[Collagen gels, chondroitin-4-sulfate. Proteolytic stability].
Differential scanning microcalorimetry and polarized thermomicroscopic methods were used for studying of collagen type I and chondroitin-4-sulfate complexes. It was shown that fast heating till 37 degrees C lead to collagen gel formation, which is stable for collagenase action.
Calorimetry, Differential Scanning↗
[Use of polarized thermomicroscopy for recording formation and degrading processes of collagen fibrils].
Polarized thermomicroscopic method were used for registration of collagen fibril formation and thermal degradation processes. It was compared with differential scanning microcalorimetry and optical density measurement methods and recommended as a fast method for registration of collagen fibril formation and degradation processes.
Animals↗