Biomedical subjects
Publications and source records attributed to T I Sharmazanashvili.
In the process of bacterial infection in rabbits, their livers have been studied by means of light and electron microscopy, as well as by morphometric analysis. The results evidence pathomorphologic and ultrastructural changes occurring in liver cells. These changes, probably, cause different metabolic disturbances and thus facilitate the development of destructive processes in vital organs.
In the process of the development of bacterial infections, the activity of marker enzymes in the membrane structure of liver cells has been studied in rabbits by biochemical and electron-histochemical methods. The results of these studies have shown that, simultaneously with the progressing course of cell pathology and inhibition of the function of mitochondria, microsomes and peroxisomes, the lysosomes activate for the realization of the protective function formed in the course of evolution. At the same time the excessive labilization of lysosomal membranes facilitates the development of cell pathology, which is confirmed by the accumulation of residual bodies in the cytoplasm.
The study of staphylococcal infection in chick embryo fibroblasts, carried out by electron-histochemical and morphometric methods, has revealed the presence of correlation between the degree of fibroblast destruction and the permeability of lysosomal membranes. The development of bacterial infection, depending on the presence of homologous bacteriophages in the medium, has also been studied.
The study of the phosphatase activity of chick fibroblasts in the process of staphylococcal infection by the electron-histochemical method has revealed the presence of correlation between the degree of cytoplasmic destruction in fibroblasts and the level of acid phosphatase activity. Changes in the phosphatase activity of fibroblasts in the process of bacterial infection, depending on the presence of homologous bacteriophages in the system used as a model, have also been studied.
The study of the dynamics of streptococcal infection in fibroblast cell culture by electron microscopic analysis has revealed the intracellular development of bacteria. The degree of ultrastructural cytopathology of homologous bacteriophages in the model system have been studied.