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Biomedical subjects

T Ichiwata

Publications and source records attributed to T Ichiwata.

12 recordsLinked to original sources
PubMed1996

Cancer-associated retinopathy with presumed vasculitis.

PURPOSE: To treat a 63-year-old woman who experienced fairly rapid vision loss in association with small-cell carcinoma of the lung. METHODS: She underwent a full ophthalmologic examination, including fluorescein angiography and an immunologic study by Western blot analysis. RESULTS: Fluorescein angiography demonstrated diffuse staining of the retinal vessels. She had 62-kd antiretinal antibody in her serum. Cancer-associated retinopathy was diagnosed. CONCLUSION: The staining seen on the angiogram appears to indicate vasculitis, which would cause the characteristic attenuation of retinal vessels in this disease.

Anti-Inflammatory Agents↗
PubMed1994

[Prediction of lowest PaO2 during unilateral whole lung lavage in a patient with pulmonary alveolar proteinosis--unilateral ventilation with nitrogen].

Unilateral whole lung lavage (UWLL) was performed four times in a patient with pulmonary alveolar proteinosis. PaO2 was 94 Torr even under ventilation with 100% O2. Because of the difficulty in providing adequate arterial oxygenation, extracorporeal membrane oxygenation (ECMO) was indispensable in accomplishing the first right UWLL. During the second left UWLL, the left lung was ventilated with nitrogen (N2) and an attempt was made to predict the lowest PaO2 occurring during lavage in order to establish criteria for the use of ECMO during UWLL. When both lungs were ventilated with 100%. O2, PaO2 rose to 150 Torr. PaO2 fell to 65 Torr after ventilation of the left lung with N2 while the right lung was ventilated with 100% O2 for 7 minutes. The N2 was replaced with 100% O2 and ventilation was continued for another 10 minutes to wash the N2 out of the left lung. When the tracheal tube in the left lung was clamped for 7 minutes for degassing, PaO2 fell to 59 Torr. Subsequently 1,200 ml of physiological saline was injected into the left lung, and PaO2 rose to 155 Torr. A 6 Torr difference was found between the value of PaO2 under ventilation with N2 and that of degassing, but this difference was not statistically significant. The lowest PaO2 occurring during UWLL was considered to be predictable if the unilateral lung was ventilated with N2.

Extracorporeal Membrane Oxygenation↗
PubMed1993

[Changes in plasma electrolytes during exercise in normal subjects--with special reference to the concentration of potassium and inorganic phosphate (Pi)].

In 8 healthy adults, changes in plasma electrolyte levels (Na+, Cl-, Ca2+, Pi and lactate) and respiratory parameters (VE, VO2 and VCO2) were examined during incremental exercise on a treadmill. Na+, Cl- and Ca2+ increased significantly near the end of maximal exercise and the early phase of the recovery period. Considering the 14% decrease in plasma volume, the increases in Na+, Cl-, and Ca2+ were not significant, while the increases in K+, Pi and lactate were significant. During incremental exercise, the concentration of K+ significantly correlated with minute ventilation (r = 0.994, p < 0.0001). Two minutes after the completion of exercise, K+ decreased below the pre-exercise level. The inflection point of VE on VO2 appeared earlier than that of K+ on VO2. The results suggest that some other factor which may contribute to the control of ventilation during exercise should be considered in addition to K+. Lactate and Pi began to increase 5 and 8 minutes, respectively, after the start of exercise. Even after the completion of exercise, these two parameters remained significantly higher than the pre-exercise level. During incremental exercise, the concentration of Pi increased concomitantly with time, and significantly correlated with VE. On the other hand, in the early stage of exercise, the concentration of lactate remained at the pre-exercise level. These results suggest that the increase in plasma Pi is responsible for the state of metabolism in the muscle in addition to lactic acidosis.

Adult↗