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Biomedical subjects

T Ikenaga

Publications and source records attributed to T Ikenaga.

6 recordsLinked to original sources
PubMed1979

Changes in serum isoamylase activities after fibergastroduodenoscopy and colonoscopy. Isoamylase after FGDS and FCS.

The effects of endoscopic examination on the changes in serum amylase activity were investigated in hospitalized patients without salivary and pancreatic disorders. Sixty-nine patients were selected for the peroral fibergastroduodenal endoscopy and twenty-three patients for the peranal fibercolonoscopy. Blood samples were drawn before, immediately after, 4 hrs and 24 hrs after the termination of the examinations. The serum activities of the salivary type isoamylase increased in 7 out of 69 cases 4 hrs after the examination with the fibergastroduodenoscope, but none in all 23 cases after the examination with the fibercolonoscope. On the other hand, the serum activity of the pancreatic type isoamylase did not change following both examinations. A significant rise in serum cortisol levels was induced by both examinations. There were no correlations between the rise in salivary type isoamylase and that in serum cortisol levels. These results did not suggest that the increase of salivary type isoamylase was mediated by the hypophysio-adrenocortical axis. Other possible mechanisms were discussed.

Colon↗
PubMed1978

Nasal absorption of insulin in dogs.

The intranasal application of an insulin solution in dogs resulted in the rise of plasma immunoreactive insulin and in dose-dependent hypoglycemia. The absorption of insulin from this site was found to be enhanced when insulin was dissolved in an acid medium. In addition, when an insulin preparation with some surfactant was used, the effectiveness of nasally administered insulin was 25 to 30 per cent of that achieved with intravenously administered insulin.

Absorption↗
PubMed1978

Effect of propranolol on regional myocardial function in anesthetized open-chest dogs with myocardial ischemia.

Effects of propranolol on ischemic segmental function were studied in anesthetized open-chest dogs. Two segment-length gauges were used for measuring the regional myocardial function: one was sutured on to the left ventricular surface perfused by the anterior descending coronary artery (ischemic zone) and the other was on to that perfused by the circumflex coronary artery (normal zone). A bolus of propranolol (0.5 mg/kg) was injected into the right femoral vein. Five min later, the left anterior descending coronary artery (LAD) was completely occluded for one mine and thereafter released. Then a second coronary occlusion for 20 min was performed; an interval of 20 min was allowed between two occlusions. Propranolol, in the ischemic segment, apparently decreased the extent of paradoxical lengthening in the late systole following one min LAD occlusion, and facilitated improvement of segmental function after release of the occlusion. Moreover, the extent of abnormal stretching induced by 20 min occlusion during early systole, was also reduced by propranolol pretreatment. In contrast, compensatory increase in shortening by the normal segment was disturbed by propranolol. These results suggest that propranolol might exert a favourable influence on the segmental myocardial function during either transient or maintained myocardial ischemia.

Animals↗
PubMed1978

A patient with repeated syncopal attacks after using isosorbide dinitrate.

The case of a patient with repeated attacks of collapse induced by sublingual isosorbide dinitrate is reported. The patient was an 81 year-old female who was admitted to Yura Hospital because of attacks of precordial pain. Several minutes after the sublingual administration of isosorbide dinitrate (10 mg) for an anginal attack, she developed a sensation of general weakness, and thereafter because unconscious. Arterial blood pressure fell and became unmeasurable. Electrocardiograms recorded during the syncopal attack showed sinus tachycardia and significant elevation of ST-segment in right precordial leads. In response to a drip infusion of noradrenaline, arterial blood pressure returned to normal with recovery of consciousness. Two similar syncopal attacks induced by sublingual isosorbide dinitrate occurred in the next three days. These attacks were not due to augmentation of the vagal reflex. Decrease of venous return probably was the primary etiological factor.

Aged↗