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T Inagawa

Publications and source records attributed to T Inagawa.

At least 73 records · Page 4Linked to original sources
PubMed1988

A case of malignant teratoma developing from the septum pellucidum 7 years after removal of a mature teratoma in the pineal region.

A report is presented on a case of teratoma with a malignant component arising from the septum pellucidum 7 years after total surgical removal of a mature teratoma in the pineal region. The patient was successfully treated with radiotherapy and total surgical resection of the second tumor. The case is characterized by the development of a second malignant tumor and by the long interval from complete resection of the primary tumor to the occurrence of the second tumor. Our case is not considered to be a recurrence of the mature teratoma of the pineal region but to be a multiple tumor of germ-cell tumor having multicentricity and a different temporal variety.

Adolescent↗
PubMed1988

Aneurysmal subarachnoid hemorrhage in Izumo City and Shimane Prefecture of Japan. Incidence.

During the 5-year period from 1980 to 1984, the incidence of subarachnoid hemorrhage due only to rupture of aneurysms was investigated in Izumo City, a small city with a population of 79,026. Additionally, to ascertain the relation of incidence to the size of the geographic area and/or population, a similar analysis was made on a larger area of Shimane Prefecture, including Izumo City, with a total population of 789,712. During this 5-year period, a total of 83 patients with aneurysmal subarachnoid hemorrhage were hospitalized in Izumo City, 548 patients in Shimane Prefecture. Ruptured aneurysms were confirmed in 77 cases (93%) in Izumo City and 466 cases (85%) in Shimane Prefecture. The crude annual incidences of aneurysmal subarachnoid hemorrhage for Izumo City and Shimane Prefecture were 21.0 and 13.9 per 100,000 population for all ages, and the age-adjusted annual incidences (adjusted to the 1980 population of Japan) were 18.3 and 11.0 per 100,000 for all ages, respectively. For both Izumo City and Shimane Prefecture, the age-specific annual incidences peaked at the ages of 50-69 years, and the highest incidence was 92.3 per 100,000 men from Izumo City in the eighth decade of life. The annual incidence of subarachnoid hemorrhage for Izumo City is the highest reported to date. If a wider area, such as Shimane Prefecture, were studied many patients in poor condition, particularly elderly patients, would be missed. To determine accurately the incidence of aneurysmal subarachnoid hemorrhage, it thus might be better to conduct the study in a small city such as Izumo City.

Adult↗
PubMed1988

Aneurysmal subarachnoid hemorrhage in Izumo City and Shimane Prefecture of Japan. Outcome.

The overall outcome of patients with aneurysmal subarachnoid hemorrhage was investigated in Izumo City and Shimane Prefecture. Of the patients from Izumo City, the clinical grade on admission was Grade I or II in 41% and Grade IV or V in 31%. Of those from Shimane Prefecture, 49% were graded as Grade I or II and 24% as Grade IV or V. The overall mortality rates 1 year after subarachnoid hemorrhage were 46% for Izumo City and 35% for Shimane Prefecture, while the surgical mortality rates were 18 and 15%, respectively. The mortality rates were particularly high among the elderly over the age of 70 years and among unoperated cases. The leading cause of death in these cases was the effect of aneurysm rupture itself, followed by rebleeding and vasospasm. The 5-year survival probabilities according to life table analysis were 50% for Izumo City and 59% for Shimane Prefecture, and a significant difference was observed in survival curves between Izumo City and Shimane Prefecture. It is concluded that the smaller the community studied, the less favorable the overall outcome, mainly because of poorer clinical conditions on admission.

Actuarial Analysis↗
PubMed1988

Management of elderly patients with aneurysmal subarachnoid hemorrhage.

A total of 299 patients with aneurysmal subarachnoid hemorrhage (SAH) were classified into three age groups, that is, those aged 59 years or younger (Group 1: 159 patients, 53%), those aged 60 to 69 years (Group 2: 85 patients, 28%), and those aged 70 years or older (Group 3: 55 patients, 18%). A comparison was made of the surgical indications and their overall management outcome in these age groups. The overall outcome at 1 year after SAH of Group 3 was significantly poorer than that of Group 1 (p less than 0.01) or Group 2 (p less than 0.01), but no significant difference could be demonstrated between Groups 1 and 2. Overall, 104 of the 299 patients died, for a mortality rate of 35%. The mortality rate by age group was 29% for Group 1, 33% for Group 2, and 55% for Group 3. Surgery was performed on 122 patients (77%) in Group 1, 56 (66%) in Group 2, and 25 (45%) in Group 3. The overall operative outcome at 1 year after SAH in Group 3 was significantly poorer than that of Group 1 (p less than 0.01), but no significant difference was observed in this regard between Groups 1 and 2. The operative mortality rate of the patients in Groups 1, 2, and 3 who were preoperatively in Hunt and Hess Grades I and II was 1%, 7%, and 22%, respectively (no significant difference). By life-table analysis the 5-year survival probability was 65% for Group 1, 60% for Group 2, and 37% for Group 3. The rate of patients surviving in good condition or in a disabled but independent condition at 1 year after SAH was 93% and no statistically significant difference in survival probability was observed among the three age groups.

Aged↗
PubMed1988

[Cranial metastasis of hepatocellular carcinoma: case report].

A case of cranial metastasis of hepatocellular carcinoma is reported. A 62-year-old man was admitted due to an elastic hard tumor in the left occipital region. On admission, neurological findings were normal and general condition was good. However, liver function was moderately abnormal. Plain craniography showed osteolytic change in the left occipital region. Computerized tomography showed bone destruction and well circumscribed high-density tumor in the left occipital region. The margin of the tumor was strongly enhanced. Left common carotid angiography revealed a hypervascular mass which was fed by the left occipital artery and the left posterior meningeal artery. A total removal of the tumor was performed, and histological diagnosis was cranial metastasis of hepatocellular carcinoma. The postoperative course was uneventful, and the patient was under medical treatment for the primary lesion.

Carcinoma, Hepatocellular↗
PubMed1988

[A case of ruptured mycotic cerebral aneurysm associated with repeated arterial narrowing and remission].

The patient is a 23-year-old male in whom aortic valve regurgitation was pointed out at the age of about 13. From July 26, 1985 he developed a high fever of 39.7 degrees C and on August 5 he suddenly became unconscious with left hemiparesis. On August 10, his consciousness became further disturbed and he was admitted to this Department on the following day. Computed tomographic scan showed subarachnoid hemorrhage and a low density area in the right temporoparietal lobe. Carotid angiography (CAG) revealed an aneurysm 10 mm in size at the end of the horizontal portion of the right middle cerebral artery (MCA) and severe narrowing of the arteries, mainly the right MCA. A mycotic aneurysm due to bacterial endocarditis was diagnosed. In the CAG conducted on August 14, aneurysm had been almost disappeared, but arterial narrowing had been further increased. On September 4, there was a remission of the narrowing, but the aneurysm could again be visualized to be 7 mm in size, which increased to 14 mm on September 20. A neck clipping of the aneurysm and an aneurysmectomy were performed on September 27. Operative findings showed degeneration and thickening of the walls of the aneurysm and arteries with inflammatory reaction. An arterial blood culture conducted at the time of a recurrence of bacterial endocarditis demonstrated non-hemolytic Streptococcus. CAG conducted on November 1 showed remarkable narrowing of the right MCA, but CAG performed on April 1, 1986 showed the narrowing to be alleviated. There is a danger of rupture in mycotic aneurysm due to bacterial endocarditis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

Rebleeding of ruptured intracranial aneurysms in the acute stage.

We analyzed early aneurysmal rebleeding in 150 consecutive patients who suffered an aneurysmal subarachnoid hemorrhage (SAH) and who were admitted within 6 hours of the initial SAH. Of these patients, 33 patients rebled. The first rebleed occurred within 24 hours in 29 patients, among whom 23 cases rebled within 6 hours. The rebleeding rate within 6 hours after the initial SAH was not related to age or sex of the patient; blood pressure on admission; size, shape, or site of aneurysm; or presence or absence of intracerebral hematoma or intraventricular hemorrhage on computed tomography (CT) scan. The patients' clinical condition and SAH on CT scan were graded I-V. Evaluation of rebleeding of those patients with grade V was difficult. In examining the rebleeding rate in grades I-IV, the higher the grade, the greater the rebleeding. Rebleeding developed during angiography conducted within 6 hours from the initial SAH in four cases. This is approximately twofold higher than the rebleeding rate within 6 hours for the total series. It is concluded that rebleeding in the acute stage is predominant within 6 hours from the initial SAH and that this rebleeding rate is higher the more severe the initial SAH is.

Acute Disease↗
PubMed1987

"Giant pneumoaneurysm" after combined internal carotid artery occlusion and extracranial-intracranial anastomosis.

A patient with a giant aneurysm of the internal carotid artery (ICA) was treated by combined ICA occlusion in the neck and superficial temporal artery to middle cerebral artery anastomosis. Six months after complete closure of the ICA, the patient had episodes of nasal discharge mixed with dark red, old blood. Computed tomographic scan demonstrated that the lumen of the giant aneurysm was filled with a large amount of air, which communicated with the nasal cavity. Not finding a similar case in the literature, we named this entity "giant pneumoaneurysm." After direct operation, the giant pneumoaneurysm collapsed. This unusual complication may be due to a decrease of blood supply to the aneurysmal wall through the vasa vasorum.

Adult↗
PubMed1986

Acute aggravation of traumatic carotid-cavernous fistula after venography through the inferior petrosal sinus.

A report is presented on a patient with acute aggravation of traumatic carotid-cavernous fistula after venography through the inferior petrosal sinus. After direct puncture of the internal jugular vein and insertion of the catheter tip to reach the inferior petrosal sinus, venography was conducted, but immediately thereafter bruit decreased and proptosis and chemosis increased. Though the fistula may have been occluded through the endarterial approach, the cause of acute aggravation is considered to have been thrombosis of the inferior petrosal sinus. The risk involved in venography or the transvenous approach for traumatic carotid-cavernous fistulas is discussed.

Accidents, Traffic↗
PubMed1985

Enzyme-immunoassay of thromboxane B2 at the picogram level.

A highly sensitive and reproducible enzyme-immunoassay for the measurement of thromboxane B2 was developed. Thromboxane B2 (TxB2) was coupled with beta-D-galactosidase by mixed anhydride reaction. Thromboxane B2-antiserum was generated in rabbits and used at a final dilution of 1:480,000. The separation of immunocomplex from the free form of TxB2 was accomplished by the double antibody method. The second antibody was sheep anti rabbit IgG. The precipitated enzyme activity was measured fluorometrically with 4-methyl-umbelliferyl-beta-D-galactoside as substrate. This method allowed to measure TxB2 in the range of 0.002-5 picomole per tube. The cross-reactivity of the anti-thromboxane B2-antiserum with 2,3-dinor thromboxane B2 was about 20%, but it was less than 0.2% for the other prostanoids tested. TxB2 extracted from human urine was measured by enzyme-immunoassay (y) and radioimmunoassay (x) which has been found closely correlated to values obtained by gas chromatography-mass spectrometry. Regression analysis of the data comparing enzyme-immunoassay and radioimmunoassay gave the equation y = 0.996 x + 0.470, correlation coefficient r = 0.9947. Inter-assay coefficient of variation was 3.1%. The assay was further simplified by coating the second antibody on glass beads. The regression equation between this solid-phase enzyme immunoassay (y) and radioimmunoassay (x) was y = 0.9860 X 1.927, r = 0.9895, and enzyme immunoassay (y) was y = 0.9749 X -0.94808, r = 0.9887. Thus, the enzyme-immunoassay shows specificity and sensitivity comparable to radioimmunoassay making use of radioactive tracer unnecessary.

Cross Reactions↗