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Biomedical subjects

T Indo

Publications and source records attributed to T Indo.

34 records · Page 2Linked to original sources
PubMed1984

A case of tardive dyskinesia caused by metoclopramide.

Abnormal involuntary movements appeared in the mouth, tongue, neck and abdomen of a 64-year-old male patient after he took metoclopramide for gastrointestinal disorder in a regimen of 30 mg per day for a total of about 260 days. The symptoms exacerbated to a maximum in a month. When the metoclopramide administration was discontinued, the abnormal movements gradually improved to a considerable extent. Attention to the possible induction of specific tardive dyskinesia is called for in the use of this drug.

Dyskinesia, Drug-Induced↗
PubMed1984

Study on the striatal dopamine availability in Parkinson's disease.

Striatal dopamine availability in connection with the plasma levodopa levels was studied in 12 parkinsonian patients treated with optimal doses of levodopa. Three patients showed the wearing-off phenomenon and the 9 others showed no daily fluctuations in disability. All of the 3 patients with the wearing-off phenomenon showed an up-and-down pattern of dopamine availability index. Out of the 9 patients presenting no fluctuations in disability, 6 showed an ascending pattern of the dopamine availability index and 3 an up-and-down pattern. Of the former 6 patients, 2 received short-term (less than one year) levodopa therapy and the other 4 had the first onset at 42 years or under. In the latter 3 patients, the onset was at over 50 years of age and the duration of levodopa treatment was more than 3 years. In these 3 patients, the mode of action of dopamine in the striatum was considered to be insufficient despite the absence of fluctuations in disability. Thus, the dopamine availability index was considered to be very significant from the viewpoint of prognosis of levodopa therapy.

Adult↗
PubMed1982

Metoclopramide-induced Parkinsonism. Clinical characteristics of ten cases.

Clinical characteristics of ten patients with metoclopramide hydrochloride-induced parkinsonism were studied. This condition was found to be more common in aged women and developed subacutely with bilateral symptoms. Clinically, metoclopramide-induced parkinsonism is sometimes accompanied by a rest tremor and may therefore be confused with Parkinson's disease. It is distinct from the latter in that orolingual dyskinesia and postural tremor are often found before the administration of antiparkinsonian drugs. The patients with metoclopramide-induced parkinsonism made a complete recovery within a few months after administration of the drug was discontinued.

Aged↗
PubMedDate not supplied

Should levodopa therapy for Parkinson's disease be started early or late? Clinical course of the major tetrad in 122 parkinsonian patients treated with levodopa over 14 years.

The study was carried out to clarify whether levodopa should be started early or late in the course of Parkinson's disease. In this study, 122 patients treated with levodopa over 14 years were included. The time course of each of the four major signs (rigidity, static tremor, akinesia and postural instability) and Yahr stage was investigated in three groups, Yahr stage I/II group, Yahr stage III group and Yahr stage IV/V group, taking into consideration the time period preceding the initiation of levodopa therapy. When the time periods in years since onset of symptoms were matched, no significant differences were recognized among the three groups. There seemed to be no benefit in delaying levodopa therapy but, rather, levodopa therapy should be started as early as possible. The declining efficacy often recognized during levodopa therapy was thought probably due to progression of Parkinson's disease itself rather than to levodopa.

Drug Administration Schedule↗