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Biomedical subjects

T J Dambro

Publications and source records attributed to T J Dambro.

3 recordsLinked to original sources
PubMed1992

Loss of radiogallium from lymphoma after initiation of chemotherapy.

A man with a high-grade lymphoma had radiogallium imaging at 48 hours postinjection, revealing three distinct sites of uptake (neck and thorax). Unknown to the authors, the patient was given cytoxan, vincristine, and prednisone intravenously 27 hours after radiogallium administration. The images at 120 hours showed markedly reduced radiogallium activity at all three sites. Possible reasons for the loss of radiogallium from the tumor sites were presented.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1992

Gallium-67 distribution in a man with a decrease in both transferrin and hepatic gallium-67 concentration.

A patient with reduced transferrin concentration had a 67Ga scintigram that showed uptake in a peritoneal abscess, pericarditis and pleural effusion but only faint liver uptake. Gallium-67 activity was measured in liver, lung, muscle and plasma samples obtained at autopsy. The percent injected dose/kg for liver and plasma samples was considerably lower than previously reported while that in muscle and lung tissues values were comparable to prior data. In this patient, sites on transferrin available to bind 67Ga were reduced from the normal 40 microM to 5.2 microM; this in turn increased the concentration of radiogallate from 1% to 7%. This elevated free activity increased 67Ga excretion and reduced the amount of 67Ga*transferrin species. These results and those of previous studies suggest that liver uptake is slower than abscess uptake and more sensitive to concentration of 67Ga*transferrin. Iron status is an important facet of the interpretation of 67Ga scintigrams.

Abscess↗