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Biomedical subjects

T J Fitzpatrick

Publications and source records attributed to T J Fitzpatrick.

10 recordsLinked to original sources
PubMed1982

Vaginal urethra, clitoral hypertrophy and accessory phallic urethra: a rare syndrome of female pseudohermaphroditism.

The rare syndrome of idiopathic female pseudohermaphroditism with vaginal urethra, clitoral hypertrophy and accessory phallic urethra is commonly associated with urinary tract obstruction. We report a new case and discuss the characteristic features. The embryogenesis of this condition seems to involve complex interactions between the müllerian duct and urogenital sinus rather than hormonal causes. Treatment is aimed at correcting the masculinized appearance of the genitalia and relieving the frequently present urinary obstruction.

Abnormalities, Multiple↗
PubMed1981

Giant vesical calculi in the female.

We herein report a case of giant vesical calculi in the female bladder. To the best of our knowledge, these calculi represent the largest group of vesical calculi ever removed from the female bladder. The etiologic factors that contribute to bladder calculus formation in the female are discussed.

Aged↗
PubMed1978

Vasovasostomy: the flap technique.

The approximation of 2 pairs of broad, transverse vas flaps at right angles to the reanastomosis permanently widens the opening into each vas lumen. All patients undergoing this procedure had sperm in the ejaculates 5 weeks postoperatively and by 6 months there was a pregnancy rate of 64 per cent.

Adult↗
PubMed1976

Hemihypertrophy of the human corpus cavernosum.

Hemihypertrophy of the right corpus cavernosum and its accompanying thickened tunica albuginea are responsible for the left lateral deviation in congenital curvature of the penis. Surgical correction is more predictable when the lengths of the dorsal and ventral curvatures of the corpora cavernosa are known.

Adolescent↗
PubMed1976

Positive inotropic action of Solanaceae glycoalkaloids.

Six glycoalkaloids and one aglycone were tested for cardiotonic activities and compared with K-strophanthoside by use of the isolated frog heart. The decreasing order of potency was as follows: K-strophanthoside greater than tomatine greater than alpha-chaconine=alpha-solanine greater than demissine=commersonine greater than beta-chaconine greater than solanidine. Cardiotonic activity was directly related to the number of sugars in the molecule in which the glycoalkaloids had a common aglycone. On the other hand, glycoalkaloids with dissimilar aglycones, but with identical sugars, such as tomatine and demissine, differed significantly with respect to cardiotonic potency. Apparently, therefore, the cardiotonic activity of glycoalkaloids on the frog heart is determined by the nature of the aglycone and the number of sugars and not by the kinds of sugars or their stereochemical configuration.

Animals↗