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T J Foster

Publications and source records attributed to T J Foster.

115 records · Page 7Linked to original sources
PubMed1975

Translocation of the tetracycline resistance determinant from R100-1 to the Escherichia coli K-12 chromosome.

Pairs of normally incompatible derivatives of R100-1 (one ChlS TetR, the other ChilR TetS) were forced to coexist in a recA host by selection for ChlR TetR cells. After many generations stable derivatives were isolated. The analysis of none independent stabilization experiments showed that in each case TetR was translocated from the plasmid to the chromosome of the host. No evidence for the joint integration of other plasmid genes (those controlling transfer, antibiotic resistance, incompatibility, or origin of transfer replication) was obtained. One of the chromosomal TetR determinants was mapped close to metE.

Chloramphenicol↗
PubMed1973

Chloramphenicol acetyltransferases specified by fi minus R factors.

Chloramphenicol acetyltransferases specified by fi(-) (F fertility-noninhibiting) R factors were compared with those specified by the fi(+) R factors R1, 222, and R6-S. Three classes of enzyme were distinguished: class I was determined by group N fi(-) R factors and was indistinguishable from the enzyme determined by fi(+) R factors, class II was correlated with group W fi(-) R factors, and class III was determined by R387, an unclassified fi(-) R factor.

Acetyltransferases↗
PubMed1973

Deletion map of the chloramphenicol resistance region of R1 and R100-1.

Recombination between single-site and multisite chloramphenicol-sensitive mutants of the F-like R factors R1 and R100-1 indicates that the chloramphenicol resistance region is a single structural gene coding for the 20,000-molecular weight subunit of chloramphenicol acetyltransferase.

Chloramphenicol↗