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Biomedical subjects

T J HALEY

Publications and source records attributed to T J HALEY.

At least 55 records · Page 3Linked to original sources
PubMed1957

Intraventricular administration of reserpine and its metabolites to conscious cats.

Intraventricular injection of reserpine in conscious cats produced relaxation of the nictitating membrane, miosis with narrowing of the palpebral fissure to a slit, avoidance of light, diarrhoea, anorexia, and tranquillization. Equivalent doses of trimethoxybenzoic acid, reserpic acid or methylreserpate separately or in combination did not produce such effects, indicating that these reserpine metabolites were not involved in these reserpine actions. 5-Hydroxytryptamine alone or in combination with subthreshold doses of reserpine also did not duplicate the effects observed after effective doses of reserpine. The possible central sites of reserpine action are discussed.

Animals↗
PubMed1957

Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.

A method has been described for the study of the central effects produced by the intracerebral injection of drugs in the unanaesthetized mouse. The effects observed were in good agreement with those obtained after similar injections in cats, dogs and human beings. After intracerebral injection, drugs of diverse structure produced certain generalized effects: changes in positioning of the tail, stupor, hyperexcitability and tachypnoea. Both acetylcholine and methacholine produced an akinetic seizure and depression, but the latter compound also caused lacrimation and salivation. Atropine produced piloerection, increased sensitivity to sound and touch, clonic convulsions and scratching, whereas hexamethonium caused Parkinsonian-like muscle tremors and peripheral vasodilatation. After adrenaline, hyperexcitability, exophthalmos, stupor and death from pulmonary oedema were observed, but (+)-methylamphetamine produced only piloerection and exaggerated activity in response to sound and touch. Ergotamine caused a decreased sensitivity to sound and touch, micturition, and stupor, while ergometrine caused clonic convulsions, piloerection, defaecation and stupor.

Acetylcholine↗