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Biomedical subjects

T J Kotek

Publications and source records attributed to T J Kotek.

4 recordsLinked to original sources
PubMed1997

Radium dial workers: issues concerning dose response and modeling.

The mortality pattern of women who began employment as luminizers in the radium dial industry before 1930 was followed through 1990. Hazard models with time-dependent covariates were used on mortality data either organized by individual death times or grouped into cross-classified person-year tables. These models were used to quantify trends in mortality associated with either death from or diagnosis of bone sarcoma or head carcinoma. The accumulation of skeletal doses from 226Ra and 225Ra was an important predictor of the risk of death from bone sarcoma. Women exposed to 226Ra at ages associated with active bone growth were at greater risk of bone sarcoma than women receiving even larger exposures at an age when their skeletons would have been fully developed. Exposure to only 226Ra was found to be an important predictor of risk for carcinoma of the mastoid air cells and paranasal sinuses. For the cranial sites, where adult dimensions are attained early in life, an effect of age at exposure could not be detected.

Bone Neoplasms↗
PubMed1992

Mortality among workers in a thorium-processing plant--a second follow-up.

A second follow-up of mortality was carried out for workers employed in a thorium-processing plant between 1915 and 1973. The study group comprised 3796 workers (3119 men and 677 women). Of the whole group, 926 (761 men and 165 women) were deceased and 2620 (2161 men and 459 women) were still alive, while 250 (6.6%) were lost to follow-up. For the male workers, the standardized mortality ratio (SMR) for all causes of death was 1.12 with a 95% confidence interval (95% CI) of 1.05-1.21. The SMR for the male workers was also significantly increased for all cancers (SMR 1.23, 95% CI 1.04-1.43) and lung cancer (SMR 1.36, 95% CI 1.02-1.78). For the female workers, the SMR was 0.74 (95% CI 0.63-0.86) for all causes and 0.53 (95% CI 0.35-0.78) for all cancers. The results of a Poisson regression analysis showed that there was no significant effect of the selected factors on lung cancer mortality.

Cause of Death↗
PubMedDate not supplied

Effect of arm orientation on bone mineral mass and bone width measured using the Cameron-Sorenson technique.

Bone mineral content and bone width were measured as the distal and midshaft locations in the right radius and ulna with the arm in different orientations. The values of mineral content, width, and the ratio of bone mineral content divided by width, determined at each bone site were compared to establish the effect of orientation. Seven orientations were studied, two of which involved rotations of the forearm and five of which involved rotations of the upper arm about the axis of the forearm. Rotation of the forearm was found to affect the values of one or more of the measured quantities at all of the sites. Orientation of the upper arm was found to affect the values of all quantities at the midshaft radius, but not to affect the values of any of the quantities at the other sites.

Arm↗