Biomedical subjects
Publications and source records attributed to T J Meek.
We observed 11 cases of fixed drug eruption to tetracyclines. Two cases were in a mother and her adult son, and two patients experienced fading of their lesions while continuing to take 1 g of the drug per day. Several patients were cross-reactive to different salts.
Tetracycline was compared to clindamycin as adjunctive therapy in the treatment of moderate to moderately severe acne under double-blind controlled conditions. Both antibiotics were efficacious and differences were not appreciable. Lesion counts of both comedones and pustules were reduced and clinical improvement was noted in the majority of subjects. Side effects were not a problem. The place of clindamycin in the therapeutic armamentarium of the dermatologist is discussed.