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T J Mudge

Publications and source records attributed to T J Mudge.

10 recordsLinked to original sources
PubMed1985

Peritoneal fluid 6-keto prostaglandin F1 alpha levels in women with endometriosis.

Peritoneal fluid was collected from women undergoing investigations for infertility at laparoscopy performed during the luteal phase. The volume of fluid was recorded and concentrations of 6-keto prostaglandin F1 alpha were determined by radioimmunoassay. No difference was found in either the total amount or the concentration of 6-keto prostaglandin F1 alpha in the women with or without endometriosis. Furthermore, there was no difference in the volume of peritoneal fluid between these two groups of women. We conclude that 6-keto prostaglandin F1 alpha in peritoneal fluid is not associated with macroscopically visible endometriosis.

6-Ketoprostaglandin F1 alpha↗
PubMed1983

Influence of prolactin on serum androgens in normoprolactinaemic women.

Previous studies in hyperprolactinaemic women have led to conflicting views about the influence of prolactin (PRL) on serum dehydroepiandrosterone sulphate (DS) levels. This study was designed to examine the effect of a reduction of normal levels of circulating prolactin on the serum DS concentration in twenty ovulating women treated with bromocriptine for 4 months in a double-blind crossover study. The women were recruited after initial studies of hypothalamic-pituitary, gonadal and adrenal function were assessed as being normal. Blood samples were collected in the early follicular and mid-luteal phases of both placebo and bromocriptine treated cycles, and were assayed for LH, FSH, PRL, DS, oestradiol (E2), testosterone (T), androstenedione (A) and sex hormone binding globulin (SHBG). The only significant changes were in serum prolactin which decreased from a mean level of 12.6 (s.e.m. = 0.38) to 9.7 (s.e.m. = 0.36) micrograms/l (P less than 0.0025), and DS which decreased from 4.9 (s.e.m. = 0.23) to 4.5 (s.e.m. = 0.22) mumol/l (P much less than 0.0005) after treatment with bromocriptine. Although the mechanism of this phenomenon is not clear, this study suggests that PRL may have a physiological role in modulating the tonic secretion or metabolism of DS.

Adult↗
PubMed1981

Alice through the laparoscope: the place of laparoscopy in an infertility service.

A retrospective comparison was made of the findings at laparoscopy and hysterosalpingography in 115 infertile women. In 41 of the 92 women whose hysterosalpingograms were reported as being normal, laparoscopy revealed additional pelvic abnormalities relevant to fertility, most commonly pelvic adhesions or endometriosis. This gave a false negative rate of 44% for hysterosalpingography. Conversely, in the 23 women whose hysterosalpingograms were abnormal (usually blockage at one or other cornua), laparoscopy showed no abnormality in six (a false positive rate of 26% for hysterosalpingography). These figures are compared with data extracted from the literature, and a plea is made for earlier laparoscopy in the investigation of infertility.

False Negative Reactions↗