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Biomedical subjects

T J Resnick

Publications and source records attributed to T J Resnick.

25 records · Page 2Linked to original sources
PubMed1986

Benign neonatal sleep myoclonus. Relationship to sleep states.

Neonatal sleep myoclonus is a benign syndrome characterized by myoclonic jerks occurring only during sleep and presenting in the first month of life. There are no associations with abnormal development, neurologic deficits, or seizures. The electroencephalogram is normal and has no correlation with the myoclonic jerks. The myoclonus is present in all sleep states although its frequency is state dependent and greatest during quiet sleep. It is not associated with an arousal response as previously thought. Transient serotonin imbalance and genetic factors might play a role in the pathogenesis of this disorder.

Electroencephalography↗
PubMed1986

Miller-Dieker syndrome: a disorder affecting specific pathways of neuronal migration.

A patient with the typical craniofacial features and clinical course of Miller-Dieker syndrome (MDS) was found on autopsy to have focal pachygyria rather than lissencephaly. The brainstem and cerebellum were hypoplastic, but thalami and basal ganglia were normal. We believe that MDS is a syndrome in which multiple specific pathways of neuronal migration are affected selectively, such as migration to the neocortex, migration via corpus pontobulbare, and cerebellar migration. However, another migration pathway (via corpus gangliothalamicum) is spared.

Abnormalities, Multiple↗
PubMedDate not supplied

A TIA-like syndrome associated with Mycoplasma pneumoniae infection.

A transient expressive aphasia associated with focal slowing in the electroencephalogram, is described in a patient with documented Mycoplasma infection. The hypothesis that ischemia is a mechanism for the transient clinical findings is considered in relation to animal studies.

Adolescent↗
PubMedDate not supplied

Video EEG diagnosis of repetitive behavior in early childhood and its relationship to seizures.

Differentiating seizures from pseudoseizures frequently is challenging in very young children manifesting repetitive, stereotypic behavior. Using video electroencephalographic recording, we evaluated 60 patients, younger than 10 years of age, with episodic signs and symptoms believed to be seizures despite repeatedly normal routine electroencephalograms. Nine patients (15%) had simple partial and atypical absence seizures. Twenty-four patients (40%) had pseudoseizures presenting as rhythmic movements or staring. Pseudoseizure frequency was greater than the frequency of true seizures; brief staring episodes were common. Motor pseudoseizures usually were of longer duration than true seizures and could be brought on with verbal encouragement. Furthermore, the stereotypic motor presentations were quite different from those of true motor seizures but were difficult to recognize from historic, clinical, and routine electroencephalographic data. Symptomatic patients can be clinically diagnosed by analyzing confirmed episodes with video electroencephalography.

Child↗
PubMedDate not supplied

Altered responsiveness during hyperventilation-induced EEG slowing: a non-epileptic phenomenon in normal children.

The relation between hyperventilation (HV)-induced high-amplitude rhythmical slowing (HIHARS) and altered responsiveness without generalized spike and wave activity has not been clearly defined. To test whether altered responsiveness is a nonspecific physiologic response rather than a symptom of generalized epilepsy, we assessed verbal recall ability and motor response testing in 12 healthy nonepileptic children (mean age 9.6 years). Both tasks were administered as a baseline before HV, during HV but before onset of EEG slowing, and during HIHARS. Verbal recall and motor responsiveness remained unchanged during baseline and HV before onset of slowing. During HIHARS, all children exhibited impaired verbal recall (p < 0.005) and 8 of 12 failed to respond to repeated auditory clicks (p < 0.005). Our findings indicate that in a normal setting, responsiveness may be impaired during HV in healthy nonepileptic children.

Acoustic Stimulation↗
PubMedDate not supplied

Magnetic resonance imaging evidence of hippocampal sclerosis in progression: a case report.

A 32-month-old child presented in status epilepticus (SE) involving the left side of the body. Fast spin-echo magnetic resonance imaging (FSE-MRI) with hippocampal volumetry performed < or = 24 h after the seizure showed increased T2 signal of the right hippocampus, but no atrophy. Complex partial seizures (CPS) appeared at age 33 months, and three more episodes of SE occurred between 33 and 37 months of age. Follow-up FSE-MRI at 34 and at 45 months of age demonstrated progressive hippocampal atrophy with resolution of the increased T2 signal. Her CPS became intractable and, at age 51 months, she underwent right temporal lobectomy. In the ensuing 5 months, she has had only one major motor seizure. This case demonstrates that acute increased hippocampal T2 signal intensity can occur soon after SE and hippocampal sclerosis (HS) may become evident within months in the setting of recurrent early childhood SE. This observation may support the hypothesis that early childhood SE can lead to HS. Furthermore, this case suggests that years of temporal lobe CPS may not be necessary for development of HS.

Brain Diseases↗