Biomedical subjects

T J Sinha

Publications and source records attributed to T J Sinha.

3 recordsLinked to original sources

PubMed1986

Biosoluble surgical material from 2,3-dialdehyde cellulose.

Dialdehyde cellulose (DAC) was prepared by periodate oxidation of various cellulosic materials in the form of sutures and bandages. The suitability of using DAC for making bioabsorbable sutures and antimicrobial wound dressing bandages was studied. The investigations indicated that DAC combines the requisite mechanical strength with an inherent antimicrobial nature. It was found that the oxidation of cellulose to yield DAC also rendered it bioabsorbable. The DAC was coated with different concentrations of urea formaldehyde in order to improve the mechanical properties for making sutures.

Aldehydes↗

PubMed1981

An insulin delivery system from oxidized cellulose.

Cellulose oxidized with periodate (OC) has been shown to be a biocompatible, biodegradable matrix suitable for immobilization and sustained release of drugs. In the present work, insulin was immobilized on the OC-matrix and the release profile in vivo and in vitro was examined. The hormone is bound to the matrix by Schiff's bond formation and is released by hydrolysis of this bond as well by degradation of the OC-matrix. The release can be sustained over longer periods by reducing the Schiff's base with NaBH4. The insulin depots could be conveniently injected as suspensions and are able to maintain glucose levels in diabetized rabbits at normal values over several days.

Animals↗

PubMedDate not supplied

Blood-cellulosics interactions.

Biomedical applications of various Cellulosics have been reviewed and their interaction with blood is discussed. A new haemostatic agent 2,3,6 - tricarboxy cellulose "Supercel" has been produced by NO2 oxidation of 2,3 - dialdehyde cellulose and a possible mechanism for blood clotting initiated by Supercel is presented.

Biocompatible Materials↗