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Biomedical subjects

T J Sutton

Publications and source records attributed to T J Sutton.

10 recordsLinked to original sources
PubMed1986

Dyspnoea and thoracic spinal deformation in rats after oral prizidilol (SK&F 92657-A2).

Prizidilol (SK&F 92657-A2), an anti-hypertensive agent, has undergone a range of prescribed toxicity studies required for the investigation of possible adverse drug effects. During the second year of the 2-year rat oral study, a variety of symptoms were exhibited by males receiving 1600 mg of the compound day-1kg-1 by gavage. These animals became lethargic, slouched and developed dyspnoea which became progressively more severe during the course of the study. Necropsy of the affected rats revealed severely haemorrhagic lungs, cardiac hypertrophy and lordosis of the spine into the thoracic cavity. At the 2-year terminal kill, a proportion of the male rats receiving 100 and 400 mg of prizidilol day-1kg-1 were identified with similar but less severe spinal deformation. No female was found with spinal changes but all the rats receiving prizidilol showed haemorrhagic lungs and enlarged hearts. The lordosis of the affected males was always confined to the thoracic spine and this, along with the cardiac hypertrophy, presumably led to marked reduction in the volume of the thoracic cavity, inducing the dyspnoea. Thoracic vertebral body damage, possibly a precursor to the spinal deformities, was found in male rats from both drug-treated and control groups. The nature of the spinal lesion is at present under investigation.

Adrenergic beta-Antagonists↗
PubMed1977

Radiological manifestations of neonatal renal vein thrombosis on follow-up examinations.

Renal atrophy involving all or part of one or both kidneys was found in 10 children with renal vein thrombosis who had been given conservative treatment. This appearance is nonspecific and can be found in any condition which disturbs the renal parenchyma. However, in a significant number of patients calcification produced a pathognomonic radiological pattern. Awareness of these late radiological manifestations may help in recognizing those cases in which renal vein thrombosis went unnoticed in the neonatal period and the patient is now found to have a perplexing radiological appearance.

Female↗
PubMed1977

[Pyelocalyceal submucosal hemorrhage in a child treated with oral anticoagulants].

A 15 1/2-year-old girl with disseminated lupus erythematosus presented with acute flank pain and hematuria during oral anticoagulant therapy for thrombophlebitis of the lower extremities. The intravenous pyelogram demonstrated multiple filling defects of the renal collecting system interpreted as pyelocalyceal submocosal hemorrhage. This benign complication disappeared following adjustment of the anticoagulant therapy. An identical appearance has been described in a case of aplastic anemia, Henoch-Schonlein purpupa, and in renal truma. Submocosal hemorrhage of the renal collecting system is to be differentiated from pyeloureteritis cystca, uroepithelial tumor, vascular impressions from collateral circulation and submucosal edema.

Administration, Oral↗
PubMed1976

Prolactin-secreting pituitary microadenomas.

Prolactin-secreting pituitary microadenomas have been surgically selectively removed in 20 patients presenting an amenorrhea-galactorrhea syndrome, hyperprolactinemia and radiological modifications of the sella turcica. In these patients, the sella was of normal size but hypocyloidal tomography evidenced subtle changes characterizing pituitary microadenomas. The surgical intervention has been based on the twin criteria of hyperprolactinemia and sellar findings.

Adenoma↗
PubMed1975

Two unusual conditions simulating ectopic ureterocele. Unilateral hydrometrocolpos with ipsilateral renal agenesis or hypoplasia, and ectopic ureteral opening into a seminal vesicle.

The clinical and radiologic findings in two infants are presented, one with unilateral hydrometrocolpos and ipsilateral renal agenesis or hypoplasia and the other with ureteral duplication with one of the ureters opening into a cystically dilated seminal vesicle. The excretory urograms of both infants suggested ectopic ureterocele. Further radiologic investigation, including lateral views of the bladder, led to the correct preoperative diagnosis. Both conditions are relatively rare, and their appearance simulating ectopic ureteroceleis even more uncommon.

Female↗
PubMed1975

[Renal localization of lymphosarcoma in the child (author's transl)].

Eight children with renal localization of a lymphosarcoma are presented. Intravenous pyelography is generally carried out in the systematic full check-up of a known case of lymphosarcoma, in order to determine the degree of extension of the disease and in order to adapt chemotherapy. The different radiological appearances are discussed. They more frequently lead to the diagnosis of more well known conditions when the diagnosis of lymphosarcoma has not yet been established.

Adolescent↗