PubMed Health⌕ Search

Biomedical subjects

T J Whitbread

Publications and source records attributed to T J Whitbread.

15 recordsLinked to original sources
PubMed2000

Idiopathic salivary gland enlargement (sialadenosis) in dogs: a microscopic study.

A histological, histochemical and morphometric study was performed on submandibular salivary glands from 13 dogs which had presented with a submandibular mass or swelling that proved to be a portion of non-inflammatory and non-neoplastic submandibular salivary gland. There were no consistent changes in lectin-binding histochemistry or immunohistochemical expression of various cell markers, and, in most cases, there was no measurable difference in acinar size in the affected gland. The possible explanation for the clinical salivary gland enlargement is therefore unclear.

Animals↗
PubMed1999

Obstructive inflammatory laryngeal disease in three cats.

Three cats with upper respiratory tract obstruction due to laryngeal inflammation are presented. Cervical radiography showed the presence of a soft tissue mass in the laryngeal region in all cases, and laryngoscopy allowed direct visualization of a mass associated with the larynx. Laryngeal samples were obtained by a combination of fine needle aspiration, cutting biopsy forceps, by ventral laryngotomy, and at post-mortem. Histopathology of the laryngeal samples showed the presence of a predominantly granulomatous inflammation, with macrophage and lymphocyte infiltration. One case was euthanased due to severe dyspnoea. The remaining two cases underwent combined medical (corticosteroid and antibiotic) and surgical (permanent tracheostomy or excision of laryngeal tissue by ventral laryngotomy) treatment. One case died of an undetermined cause 15 weeks after surgery while the other case remains clinically well 20 months after diagnosis. Recognition of the existence of granulomatous laryngitis is important as clinical signs and radiographic findings are indistinguishable from laryngeal neoplasia.

Animals↗
PubMed1999

Plexiform vascularisation of a retropharyngeal lymph node in a cat.

Plexiform vascularisation of a retropharyngeal lymph node is described in an adult cat. The cat presented with a chronic history of inspiratory stridor and a slowly growing mass in the cranial cervical area. Clinical signs resolved after excision of the affected node. This appears to be the first clinical report of plexiform vascularisation of a retropharyngeal lymph node and its treatment in a cat.

Animals↗
PubMed1997

Lipomatous infiltration of the canine salivary gland.

Benign connective tumours of the canine salivary glands are rare. This report describes lipomatous infiltration of parotid or submandibular salivary glands in seven dogs in which the glands were enlarged as a result of infiltration by fat cells; they appeared to have been successfully treated by local excision. The precise cause of the lipomatous infiltration in the dogs is unclear but different causes of similar lesions in humans are discussed.

Animals↗
PubMed1990

A connective tissue defect in two rabbits similar to the Ehlers-Danlos syndrome.

A connective tissue disease resembling the human Ehlers-Danlos syndrome is reported in two sibling rabbits about four months old. The clinical signs included skin hyperextensibility and fragility and poor wound healing. There were ultrastructural abnormalities in the structure of the collagen fibrils and in their arrangement in bundles of fibres. Affected rabbits may be a useful laboratory animal model for collagen disorders in human beings.

Animals↗
PubMed1987

Plexiform vascularization of lymph nodes: an unusual but distinctive lymphadenopathy in cats.

A distinctive lymphadenopathy in nine cats, four of which were of the Longhair breed, was characterized by capillary vasoproliferation and lymphoid atrophy. It occurred in the cervical or inguinal regions. The animals were, apart from local manifestations, healthy at the time and remained so subsequently. In the absence of any clinical or morphological evidence for viral, neoplastic or developmental aetiologies, we postulate an ischaemic pathogenesis for the lesions which may be related to human "vascular transformation of lymph node sinuses". The lesions appear to be by no means a rare cause of non-neoplastic lymphadenopathy in domestic cats, since they constituted over 5 per cent of surgical biopsies of cat lymph nodes seen in the past 5 years. The lesions merit wider recognition and investigation.

Animals↗
PubMed1986

Simple technique for examining lymphocyte blastogenesis in whole blood cultures for neonatal calves.

A method for examining lymphocyte blastogenesis in whole blood cultures of neonatal calves is presented. Considerable variation in magnitude of thymidine incorporation was noted between animals but the general trend of response was uniform. Maximum responses occurred at different culture times for each mitogen. In a standard 0.2 ml micro culture system using 10,000 mononuclear cells per culture incubated for 96 hours in 5 per cent fetal bovine serum maximum mitogenic responses were obtained with 0.8 microgram phytohaemagglutinin per culture, 1 microgram concanavalin A per culture and 0.08 microgram pokeweed mitogen per culture.

Animals↗
PubMed1984

Relative deficiency of serum IgA in the german shepherd dog: a breed abnormality.

Serum immunoglobulin concentrations in clinically healthy German shepherd dogs were compared with those in mongrel dogs and Irish setters. Serum IgA concentrations were significantly lower in the German shepherd dogs than in the other two groups, while there were no differences in the concentrations of IgM or IgG. These findings suggest that production of IgA by gut associated lymphoid tissue may be abnormally low in the German shepherd dog.

Animals↗