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Biomedical subjects

T J Zhou

Publications and source records attributed to T J Zhou.

5 recordsLinked to original sources
PubMed1992

Impaired blood superoxide dismutase in the traumatic paraplegic patients.

Blood superoxide dismutase (SOD) activity and blood copper, zinc-superoxide dismutase (Cu.Zn-SOD) content were measured by luminol chemiluminescence assay and by single radial immunodiffusion assay, respectively, in 50 patients with paraplegia due to traumatic injury to the spinal cord by the Tangshan Earthquake on July 28, 1976, compared with 20 age-matched healthy subjects. We found that blood SOD activity and blood Cu.Zn-SOD content in the paraplegic patients were significantly lower than those in healthy subjects (p < 0.01). In healthy subjects, blood Cu.Zn-SOD fully expressed the enzymatic activity, whereas only 77% of blood Cu.Zn-SOD in the paraplegic patients expressed the enzymatic activity, indicating that in the patients, part of blood Cu.Zn-SOD protein is in a state without function. Also the serum lipid peroxide level in the paraplegic patients was higher than that in healthy subjects (p < 0.05). These findings suggest decreased endogenous blood protection against oxygen derived free radicals in these paraplegic patients.

Adult↗
PubMed1989

Primary study of attenuated live hepatitis A vaccine (H2 strain) in humans.

Strain H2, an attenuated live hepatitis A virus (HAV), was derived from the fecal specimen of a patient with hepatitis A in Hangzhou, China. After isolation and passage in a culture of newborn monkey kidney cells, adaptation to grow in human lung diploid cells (KMB17), and serial passage at a low temperature (32 degrees C) in KMB17 cells, this strain became the master seed virus for H2-strain vaccine. Twelve human volunteers received the experimental vaccine subcutaneously and were closely observed for 20 w. None of the subjects developed any local or systemic reactions, and there were no elevations of serum glutamic-pyruvic transaminase, type 5 isoenzyme of lactate dehydrogenase, or isocitrate dehydrogenase. Seroconversion occurred in all subjects at a mean time of 3 w after inoculation. ELISA competitive test for titer of antibody to HAV showed values ranging from 1:2 to 1:8 with a geometric mean titer of 1:3.48 at 20 w after inoculation. No marked decrease in titer of HAV antibody was found in the subjects tested at 1 y. These antibodies were proved to be neutralizing antibodies.

Adult↗
PubMed1989

[A renal function survey in paraplegic patients of the Tangshan earthquake].

The writers had investigated 307 patients with paraplegia caused by Tangshan earthquake on July 28, 1976 and analysed their renograms. The results showed that the incidence of the abnormal renogram was 22.8% and significantly higher in the males and the patients with urinary incontinence than in the females and patients with urinary regularly. The renography was compared with the ultrasonography and their coincidence ratio was 93.5%. The relation among the abnormal renogram, urinary incontinence and sex is discussed.

Adult↗
PubMed1987

[Telangiectatic osteosarcoma--a case report].

Telangiectatic osteosarcoma, being a subtype of osteosarcoma, is rare. In this paper, one case is reported. The patient, a sixteen year old man, was admitted into our hospital in 1983 because of swelling and pain in the left knee for 3 months. On physical examination, a mass, 7 x 5 x 5 cm in size, was found in the distal end of the left thigh. A misdiagnosis of hemangioma of the bone was made by puncture biopsy before operation. After three months, the disease progressed and amputation had to be performed. The pathological diagnosis of telangiectatic osteosarcoma was established after operation. Finally, clinical and roentgenographic manifestations, histological and ultrastructural findings, biologic behavior, diagnosis and differential diagnosis are discussed. In particular, the differentiation from aneurysmal bony cyst and hemangioma of the bone is emphasized.

Adolescent↗