Alternative method for predicting phenytoin levels.
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Humans↗
Biomedical subjects
T Jochsberger
Publications and source records attributed to T Jochsberger.
Differential pulse polarography of tetracycline: determination of complexing tendencies of tetracycline analogs in the presence of cations.
The complexation tendencies, stoichiometries, and stability constants for tetracycline, minocycline, and demeclocycline with the metallic ions calcium(II), magnesium (II), zinc(II), aluminum(III), iron(II), and iron (III) were evaluated using a polarographic technique. Changes in pulse peak heights for each tetracycline deravative were measured as a function of cation concentration. The method provides an in vitro method of evaluating the selectivity of particular metal ions for different tetracycline analogs.
Aluminum↗
Precautions in the use of Michaelis-Menten kinetics in the prediction of phenytoin levels.
The Michaelis-Menten equation is one of the various techniques available for predicting steady-state plasma levels of phenytoin. In actual practice, however, data are not always available or reliable. This case report emphasizes the importance of establishing the quality of the data and determining that steady state has been achieved. The addition of a third point to the graph used to estimate parameters greatly increases prediction accuracy.
Child↗