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T Juszkiewicz

Publications and source records attributed to T Juszkiewicz.

14 recordsLinked to original sources
PubMed1992

Teratological evaluation of Ukrain in hamsters and rats.

The compound Ukrain, containing thiophosphoric acid alkaloid derivatives from the plant Chelidonium majus L., was given intramusculary (i.m.) on days 6-11 of gestation to hamsters and on days 6-15 of gestation to rats in doses of 0.1, 1.67 and 28 mg/kg daily. No clinical signs of toxicity were found in treated animals and no teratogenic effect could be noted in either species. Such parameters as the number of corpora lutea, implantation sites, pre and post-implantation losses, number of live foetuses per litter, placental weight, foetal weight and crown-rump length were not significantly different between the Ukrain treated rats and the controls. Slight embryotoxic effects (increased post-implantation losses) and in consequence decreased number of average litter size were noted in hamsters exposed to Ukrain at doses which were otherwise not embryotoxic to rats.

Alkaloids↗
PubMed1978

Absorption, tissue deposition and passage into eggs of N-nitrosodimethylamine in hens.

The experiments were performed on 262 laying hens divided into 8 groups: 5 groups of hens were given orally N-nitrosodimethylamine (NDMA) in single doses of 30, 10, 3, 1 and 0.1 mg/kg of body weight, two groups received tap water containing 2 and 5 mg NDMA/kg, provided ad libitum for 20 consecutive days, and one group of layers served as a control. Birds were selected at random and sacrificed at one or two day intervals and NDMA content was determined in blood, muscles, liver, brain and in collected eggs. The highest concentrations of NDMA were found 24-36 hours after dosing in all investigated tissues and eggs. A single oral dose of 0.1 mg NDMA/kg produced tissue levels up to 0.06 mg/kg and resulted in excretion of detectable amounts of the carcinogen in eggs for up to 6 days. After large doses, 10 mg and 30 mg NDMA/kg, concentrations in corresponding tissues reached 6.0 and 12.7 mg/kg, and the presence of NDMA in eggs could still be detected after 12 and 14 days. Birds receiving NDMA in drinking water showed increasing NDMA concentrations in all analysed tissue and eggs. After 12 days, the highest levels were found in eggs, blood and brain. Practical implications of the results must be evaluated from the point of view of human safety.

Animals↗
PubMed1977

Mycotoxins in grain for animal feeds.

A total of 302 crushed grain samples of barley, wheat, rye, corn and oats from the crop year 1974 were collected from commercial feed processing plants situated in all the provinces (voivodeships) of Poland. For the mycotoxin survey, performed according to the multimycotoxin detection method by Stoloff et al (1971), 150 grain samples were taken. The positive samples were analysed thereafter by the procedures for the individual mycotoxins and chemical confirmatory tests. Of the 150 samples tested by the multimycotoxin detection method, 77 (51 p. 100) showed fluorescing spots and Rf values of aflatoxins, 24 (16 p. 100) were of ochratoxins, 11 (7 p. 100) of zearalenone and 5 (3 p. 100) of sterigmatocystin. However when these samples were assayed by the specific methods and confirmatory procedures, only 8 (5 p. 100) samples were found to be positive, containing ochratoxin A at the level ranging from 50 to 200 microgram/kg.

Animal Feed↗
PubMed1975

[Effect of semen diluters containing egg yolk contaminated with DDT on the survival of bull spermatozoa].

In two experiments, hens received 200 (group I) or 100 ppm of DDT per day and per kg of live weight (group II), for 17 or 10 days resp. The eggs of experimental hens were collected, and a 3 or 6 day collection of eggs was used for preparing a sample of pooled egg yolks; one part of this sample was used for preparation of a 25% egg yolk-citrate diluent, the other for DDT determination. The egg yolks of experimentally poisoned hens contained 12 to 957 ppm of DDT (egg yolks of controls 1-4 ppm) in consecutive collection samples. However, the survival time and survival indexes of bull semen (90 ejaculates) preserved at 3 degrees C and 46 degrees C in yolk citrate diluent containing DDT poluted egg yolk did not differ from those preserved in control diluter.

Animal Feed↗
PubMedDate not supplied

Occurrence of mycotoxins in animal feeds.

A total of 1120 grain samples of oats, wheat, rye, barley, and maize, delivered for processing of mixed feeds for animals, were collected during the years 1975 to 1979 from commercial feed mills located throughout Poland. In addition, 625 samples of the commercially mixed feeds and protein concentrates were collected during 1976. For the mycotoxin survey, 751 laboratory samples were chosen at random and analyzed. When applying confirmatory tests neither aflatoxins B1, B2, G1, G2 nor sterigmatocystin, zearalenone, or ochratoxin B were found to be present in any of the samples of barley, wheat, rye, or oats. Aflatoxins were detected in about 4% of the maize samples. The presence of ochratoxin A in the range of 2 to 200 micrograms/kg was evident in 9% of the grain samples. The commercially mixed feeds were found to be more contaminated with mycotoxins than were the grains. The aflatoxins were confirmed in about 13% of the samples of mixed feeds. After the preliminary multimycotoxin analysis, out of 42 feed samples that could be suspected of containing ochratoxins, 32 failed to prove their presence. Similarly, out of 27 suspected feed samples, zearalenone was found only in one (0.5%) sample. The lowest percentage of samples contaminated with mycotoxins was found in poultry mixed feeds (4%). The highest contamination occurred among the samples of swine rations, where 17% of the samples contained aflatoxins and 13% ochratoxins. The protein concentrates contained only aflatoxins. Out of 31 analyzed samples, aflatoxins were detected in 19 (61%) in concentrations ranging from 5 micrograms/kg to 500 micrograms/kg. In one sample, aflatoxin concentration (B1 + B2) reached 1140 micrograms/kg. Practical implications of the results are discussed in relation to animal and human safety.

Aflatoxins↗