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T K Asoskova

Publications and source records attributed to T K Asoskova.

11 recordsLinked to original sources
PubMed1991

[Level of antibodies to different determinants of Streptococcus group A polysaccharide and autoantibodies to basal layer of the skin epithelium in rheumatism].

Direct dependence was established between the presence of autoantibodies reacting with the basal layer of the skin epithelium (BLSE) and the high level of antibodies to the streptococcal group A polysaccharide (APS). By the primary active rheumatic fever (PARF) autoantibodies to the BLSE are revealed. By the recurrent active rheumatic fever (RARF) and in the control sera, autoantibodies reacting with the BLES, apparently, are directed to the rhamnose determinants of APS. These data confirm: different level of antibodies to the GS and to the rhamnose determinants of APS by PARF, RARF and in the control sera; the experiments of the autoantibody inhibition, reacting with the BLSE by the APS or the polysaccharide of streptococci A-variant, containing only the rhamnose determinants.

Adolescent↗
PubMed1991

[Comparison of the frequency of detection of autoantibodies to epidermal antigens with the level of antibodies to polysaccharide of group A Streptococcus and the number of T-suppressors in glomerulonephritis].

By the acute glomerulonephritis (GN) of streptococcal etiology, autoantibodies (AA) reacting with the basal layer of skin epithelium (BLSE) are discovered. The presence of this AA's correlate with the high level of antibodies to the streptococcal group A polysaccharide (A-PS). In the control sera such AA's and the high level antibodies to A-PS are discovered very rarely. By the GN of non-streptococcal etiology, AA's to the BLSE apparently of other specificity are obtained in some cases, in spite of the absence of antibodies to A-PS. AA's reacting with the differentiated layers of skin epithelium are discovered in the high percent of cases by GN. The presence of these AA's do not correlate with the levels of antibodies to A-PS. The reduction of the number of T-lymphocyte suppressors is established in the blood by the presence of AA's to the BLSE by GN. This question is a subject of later investigations by the different autoimmune processes. Such data can apparently corroborate the previously expressed hypothesis, that AA's to BLSE, which as a rule react with endocrine thymus epithelium, are the cause of the beginning of immunoregulatory disorders, characteristic of autoimmune processes.

Acute Disease↗
PubMed1990

[Suppression of cytotoxic cellular reactions by the production of antibodies to rhamnose determinants of streptococcal group A polysaccharide cross-reacting with antigens of the skin epithelium].

By the BALB/c mice after different periods of immunization with the streptococci group A, treated with pepsin, antibodies belonging to autoantibodies to the determinants (DT) of polysaccharide (A-PS), cross-reactive (CR) with the epithelial skin cells, were investigated. In one of the mice groups, in the autologous system, on the target cells--macrophages of lymph nodes, the suppression of cytotoxic (CT) reactions was obtained. The CR are bound with the delayed type hypersensitivity appearing after the sensibilization with BCG. The suppression effect correlate (z-0.95) with the presence in the sera antibodies to the rhamnose DT'S of A-PS, which cross-react with the cells of basal and superbasal layers of skin epithelium. Antibodies to the group specific of the A-PS, cross-react only with the basal skin layer and not produce the suppression of CT reactions. It is possible that they also prevent the suppression of CT reactions, bound with the CR antibodies to the rhamnose DT-S of A-PS. The obtained data corroborate the earlier supposition that the autoantibodies to the CR DT'S of A-PS reacting with the skin epithelial cells as a rule common the thymus epithelial cells. It is possible that different IRD'S can prevent or stimulate the development of autoimmune processes by the infections with the streptococci group A.

Animals↗
PubMed1987

[Phage sensitivity of Streptococcus group A strains isolated in glomerulonephritis].

The study of phage-sensitive strains of group A streptococci of different serological types, isolated from glomerulonephritis patients in Czechoslovakia, has confirmed the data previously obtained in Moscow. As revealed in this study, all strains of type 12, containing M-antigen, are sensitive to group 1 phage from the phage collection used in the investigation. Some of the strains of type 12, containing M-antigen and isolated from healthy carriers, have also proved to be sensitive to group 1 phages. Thus, streptococcal strains of type 12, containing M-substance and found to be the main causative agents of glomerulonephritis, have shown similar phage sensitivity when isolated in different geographical zones. For this reason, group 1 phages can be used for the detection of some "nephritogenic" strains among the population.

Acute Disease↗
PubMed1978

Immunodiffusion method for identification of group A streptococci.

The development of a method suitable for identification of group A streptococci by microprecipitation in gels is described. The method is based on preparation of specific sera containing high antibody levels agains the antigenic determinant characteristic of group A streptococcal polysaccharide. In a comparative study with a counterimmunoelectrophoresis method, the proposed test proved to be specific, easily read, and less complicated. Results were obtained in 2 h.

Antibodies, Bacterial↗
PubMedDate not supplied

[The phage sensitivity and lysogeny of cultures of Streptococcus pyogenes group A isolated in different streptococcal infections].

The collection of moderate phages of S. pyogenes, group A, had been created earlier. As shown in this work, group A streptococcal cultures isolated from patients with rheumatism, glomerulonephritis and tonsillitis exhibited different sensitivity to the phages of this collection: the cultures were lyzed by phages of groups II and III in rheumatism, group III in tonsillitis and group I in glomerulonephritis. The study revealed that lysogeny was widely spread among S. pyogenes strains isolated from patients with different diseases under study. Most frequently occurred among cultures isolated from tonsillitis patients. In this disease only phage-resistant streptococcal cultures proved to be lysogenic. Lysogeny was found among both phage-sensitive and phage-resistant cultures in rheumatism and especially in glomerulonephritis.

Bacteriophage Typing↗
PubMedDate not supplied

[Specificity of a panel of monoclonal antibodies to group A Streptococcus polysaccharide and search for cross reactions with mammalian tissues].

A panel of monoclonal antibodies (McAb) to different determinants of group A Streptococcus polysaccharide (A-PS) has been studied. As revealed in this study, A-PS contains at least 4 determinants, common with different epidermal antigens. McAb, cross-reacting (CR) with different mammalian tissue antigens, have not been found to be group-specific. Experiments on the inhibition of the immunoenzyme reaction of McAb with A-PS indicate that CR determinants include rhamnose and beta-N-acetyl-D-glucosamine of rhamnose alone. In addition, we have confirmed our earlier suggestion that group-specific high-affinity precipitating antibodies acted on different sites of A-PS. Contrary to earlier opinions, antibodies to group-specific determinants of A-PS have been found not to react with epidermal antigens.

Animals↗