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Biomedical subjects

T K Lin

Publications and source records attributed to T K Lin.

At least 37 records · Page 2Linked to original sources
PubMed1997

Thrombolytic therapy for mitral valve thrombosis.

A 44-year-old man with a St. Jude mitral valve was admitted because of progressive pulmonary edema. He was diagnosed with prosthetic heart valve thrombosis (PHVT) based on the findings of "muffled" prosthetic valve clicks. Doppler echocardiographic evidence of severe mitral stenosis and transesophageal echocardiographic evidence of limited mitral valve motility. Because the patient hesitated to undergo our recommended surgical treatment, he was immediately treated with intravenous recombinant tissue plasminogen activator (100 mg over 3 h) followed by heparinization. Two hours after the thrombolytic therapy, the prosthetic valve clicks became clearly audible and his congestive symptoms were dramatically improved. Follow-up echocardiography no longer-showed significant mitral valve obstruction. A transient cerebral ischemic attack occurred at the end of thrombolytic therapy but there were no neurologic sequalae. The patient, on warfarin therapy, was well at follow-up 8 months after discharge. Surgical intervention has long been the standard therapy for patients with PHVT. Our case experience suggests that thrombolytic therapy may be considered as an effective alternative to surgical intervention for selected patients with PHVT. In this report, we also review the current literature regarding the indications, effectiveness and safety of thrombolytic therapy in PHVT.

Adult↗
PubMed1995

Combination chemotherapy with carmustine and cisplatin before, during, and after radiotherapy for adult malignant gliomas.

Twenty-two patients, aged 16 to 67, who had malignant gliomas after surgical resection were treated with carmustine and cisplatin intravenous infusion before, during, and after radiotherapy. All patients had subtotal or total resection, or biopsy as the initial procedure. Twenty-one patients who had at least 2 cycles of chemotherapy and finished the whole course of radiotherapy were considered to be evaluable for responses. Among them, 5 had glioblastoma multiforme, 16 had anaplastic astrocytoma. The median time to tumor progression was 35 weeks (range 12-130 weeks) and median survival time was 66 weeks (range 10-156 weeks). Early progression occurred more frequently in patients with biopsy only and subtotal resection, and in patients with glioblastoma than in those with anaplastic astrocytoma. This combined modality treatment program was associated with reversible hematologic toxicity which was severe in 2 patients, and with ototoxicity in 1 patient, nephrotoxicity in 2 patients. Combination of carmustine and cisplatin with cranial irradiation for malignant gliomas is moderately toxic and appears to offer no obvious survival advantage compared with radiation therapy plus BCNU alone.

Adolescent↗
PubMed1995

Laparoscopic ovariopexy before irradiation for medulloblastoma.

Ovarian preservation before abdominal irradiation may be recommended for young patients with various types of invasive cancer. The most common site for ovarian transposition is just below the iliac crest or posterolateral to the uterus. Here, we demonstrate laparoscopic ovariopexy with an automatic stapling device to transpose the ovaries to an uncommon site, i.e. lower anterolateral abdomen, in a patient with medulloblastoma prior to her receiving irradiation of the craniospinal axis. The anterolateral transposition of the ovary not only kept it away from the irradiated field but allowed it also to be shielded by the uterus. Thus, ovarian function could be well preserved.

Abdomen↗
PubMed1995

Recordings of pre- and postoperative sympathetic skin response in patients with palmar hyperhidrosis.

Transthoracic endoscopic sympathectomy is an accepted standard surgical treatment for hyperhidrosis palmaris. During the past 4 years, more than 500 patients underwent this kind of surgical treatment at our institution with a 98% success rate. About 50% of cases were found to have compensatory sweating. We measured the sympathetic skin response (SSR) and R-R interval variation (RRIV) in 38 normal control subjects, and 50 consecutive patients with palmar hyperhidrosis before and 2 weeks after transthoracic endoscopic T2-3 sympathectomy. Before sympathectomy SSR was absent in 36% of patients on deep inspiratory stimulation and in 20% on electrical stimulation. After T2-3 sympathectomy, SSR in the palms was absent in 64% of patients with deep inspiration stimulation and in 76% on electrical stimulation. A decrease in the SSR amplitude in the soles was found in 40% on deep inspiration and in 54% of patients on electrical stimulation. RRIV was not significantly influenced 2 weeks after sympathectomy. The high abnormal rate of SSR in the patient group indicated that an abnormal regulation of the sudomotor control center played an important role in palmar hyperhidrosis.

Adolescent↗
PubMed1995

Delayed intracerebral hematoma caused by traumatic intracavernous aneurysm: case report.

Although delayed intracerebral hematomas from head injury are not uncommon, they are extremely rare when they are caused by extradural (extracranial) pseudoaneurysms of the internal carotid artery in the cavernous sinus. The case of a 33-year-old man who sustained a delayed frontal intracerebral hematoma from a traumatic intracavernous aneurysm 32 days after a head injury is presented. Posterior frontal base fractures accounted for monocular blindness and injury over the anterior siphon of the intracavernous carotid artery, which resulted in the formation of a pseudoaneurysm inside the sphenoid sinus. Subsequently, the cranial base fractures with secondary defects provided a route for the pseudoaneurysm to rupture intracranially and also accounted for intractable cerebrospinal fluid rhinorrhea and pneumocephalus after surgical treatment for the pseudoaneurysm and the intracerebral hematoma.

Adult↗
PubMed1995

Effect of growth hormone therapy in men with severe idiopathic oligozoospermia.

Some studies have suggested that growth hormone (GH) may enhance folliculogenesis in women, and similarly may enhance spermatogenesis in men with hypogonadotrophic hypogonadism. In this prospective open-controlled pilot study, we investigated the effect of daily subcutaneous GH for 5 months in 12 endocrinologically normal men with severe idiopathic oligozoospermia (< 10 million/ml). All the men had normal karyotype and endocrine tests, including a GH response of > 20,000 mU/l to insulin hypoglycaemia. Nine men with similar sperm counts acted as controls. During treatment, each patient was examined monthly, asked for side effects and had glycosylated haemoglobin, glucose and blood counts monitored. Five semen samples were obtained in the 4 months before treatment, two samples per month during treatment and three samples after stopping treatment. The mean insulin-like growth factor I (IGF-I) was normal before treatment and 1 month after ending treatment, at 206 and 182 micrograms/l, respectively, but increased significantly during treatment to 444 micrograms/l (p < 0.0001, ANOVA). The mean (SD) sperm counts were 2.6 (2.5), 2.5 (3.7) and 2.3 (2.1) million/ml before, during and after GH treatment, respectively, and did not show any statistically significant differences (ANOVA). We conclude that GH does not increase or decrease sperm counts in men with severe idiopathic oligozoospermia.

Adult↗
PubMed1994

Surgical treatment for ossification of the posterior longitudinal ligament of the cervical spine.

Ossification of the posterior longitudinal ligament (OPLL) is a degenerative disease of the spine, usually found in the cervical vertebrae. Most symptomatic patients present with a myelopathy or myeloradiculopathy. Surgical decompression is the preferred treatment. The choice of operative approach, anterior or posterior, is still controversial. From January 1986 to June 1992, 20 patients with this condition received operations at Chang Gung Memorial Hospital. The clinical manifestations and the results of treatment are analysed. The ideal surgery seems to be the anterior approach with bone fusion. If, however, the OPLL involves more than three segments, the posterior approach with an expansive laminoplasty would be the better alternative technique.

Adult↗
PubMed1994

Chylothorax after endoscopic sympathectomy: case report.

Endoscopic sympathectomy is a new trend for the treatment of hyperhidrosis palmaris. It is a simple and effective technique; however, it carries some recognized risks such as Horner's syndrome and pneumohemothorax. We recently encountered a case complicated by the development of a chylothorax. The patient was a 23-year-old healthy women with profuse palmar sweating. She developed an intractable dry cough after a transthoracic endoscopic sympathectomy. A chest x-ray revealed a left pleural effusion. A chylous effusion was found after thoracentesis and fluid analysis. The pleural effusion resolved after chest tube drainage and diet control. Although endoscopic sympathectomy is a simple and quick procedure, unusual complications, such as chylothorax, may occur. Appropriate early recognition and treatment can prevent a disastrous result.

Adult↗
PubMed1994

[Unspecified subarachnoid hemorrhage in Taiwan].

We report the epidemiological and clinical features of unspecified subarachnoid hemorrhage by reviewing the literature published in Taiwan. Data from stroke registry from January 1988 to June 1992 showed that 4.9% of 23910 acute strokes were diagnosed as subarachnoid hemorrhage; in about half of them the cause of hemorrhage was not specified due to lack of confirmatory diagnostic examinations or to rapid deterioration of consciousness subsequent to bleeding that made angiography unapplicable during hospitalization. The age distribution, sex ratio, clinical profiles and associated risk factors in this group of patients were similar to those in the group of aneurysmal rupture. Therefore, the majority of patients categorized in the group of unspecified subarachnoid hemorrhage very likely had aneurysmal ruptures. The causes of subarachnoid hemorrhage were more frequently undetermined in hospitals where neuroradiological as well as neurosurgical facilities and staff were not immediately available, and also in patients whose clinical condition was poor on arrival at the hospital or who deteriorated rapidly after the onset. These two facts may partly explain the higher case-fatality rate and poorer prognosis in patients whose causes of subarachnoid hemorrhage were undetermined and effective surgical treatment could not be done.

Adult↗
PubMed1993

The expectant treatment of "asymptomatic" supratentorial epidural hematomas.

Seventy-four patients with a traumatic epidural hematoma (EDH) and a Glasgow Coma Scale score of more than 12 received expectant treatment; 14 subsequently underwent surgical evacuation of the EDH. A patient with initial brain computed tomograms (CT) showing an EDH volume of more than 30 ml, a thickness of more than 15 mm, and a midline shift beyond 5 mm tended to require surgery within 3 days of the injury when the brain had exhausted its compensatory mechanism and yielded to the expanding EDH. After the 3-day period, in the absence of neurological symptoms, the presence of the EDH may not be an indication for surgical evacuation or hospitalization beyond 7 days. In our patients, the presence of a skull fracture in the temporal bone, the heterogeneous density of the EDH in the CT scan, or the 6-hour period between the CT study and the injury did not significantly increase the failure rate of nonsurgical treatment. Although a zero mortality was achieved in this series, these guidelines may not be applicable to the management of an infratentorial EDH.

Adult↗
PubMed1993

Analysing a mental health survey by chi-squared automatic interaction detection.

Based on a mental health survey conducted in 1987 by the Singapore Association for Mental Health, an exploratory statistical technique CHAID (Chi-Squared Automatic Interaction Detection), which is an offshoot of AID (Automatic Interaction Detection) designed for a categorical dependent variable, was employed to establish the characteristics of people who were vulnerable to mental problems in Singapore. Of the sixteen predictors considered, five were found to play significant roles in identifying the various vulnerable groups. They were the respondent's perception of his or her own health, the number of problems encountered during the four weeks before the survey, whether experiencing a depression or not during the four weeks prior to the survey, the respondent's perception of family support and the number of life events in the past six months before the survey, summarised into a weighted score. The dendrogram obtained from CHAID was very useful in displaying the structure of the relationship of the predictors with mental health. Examining the dendrogram, one can easily classify the various vulnerable groups by tracing each of the terminal groups to the root of the tree.

Adult↗
PubMed1992

Intraventricular neurocytoma: four cases report.

Intraventricular neurocytoma, a newly identified disease entity with probably not so rare incidence, has several distinctive clinico-pathological characteristics. Four cases are presented. As in the other cases reported in the literature [1-7], the characteristic features are young age, location close to the junction of the septum pellucidum and foramen of Monro, and well-differentiated neuronal origin pathologically.

Adult↗
PubMed1992

Spontaneous intracerebral hematoma from occult carotid-cavernous fistula during pregnancy and puerperium. Case report.

In most cases, intracerebral hemorrhage during pregnancy or puerperium results from cerebral aneurysms or arteriovenous malformations. The authors present a case of a 30-year-old woman whose symptoms from a traumatic carotid-cavernous fistula had completely resolved 1 1/2 years after the event, but recurred 4 years later, causing two hemorrhages during pregnancy (33rd and 35th week of gestation) and one during the postpartum period (10 days after Caesarean section). Partial thrombosis of the cavernous sinus with obliteration of most of the drainage from the fistula accounted for the resolution of clinical symptoms, but also promoted back-flow to the preserved drainage of superficial cortical veins. The hemodynamic changes and the hormonal effects due to the patient's subsequent pregnancy further aggravated the venous engorgement and finally caused rupture. All three hematomas occurred in the vicinity of the extremely dilated veins, suggesting that back-flow with venous hypertension was the probable cause for the intracerebral hematomas. Spontaneous healing of the carotid-cavernous fistula should be confirmed with cerebral angiography.

Adult↗
PubMed1991

Cerebral arteriovenous malformations: factors influencing the surgical difficulty and outcome.

The outcomes of 151 patients with arteriovenous malformations (AVMs) treated either surgically or conservatively are presented. In terms of long-term survival rate and follow-up results, the patients who underwent total excision had more favorable results than did those treated conservatively. Patient age was the most important clinical factors, with the preoperative level of consciousness being the second most important. A grading system was formulated on the basis of the angiographical factors by using multiregression analysis; the size of the AVM influenced the surgical outcome twice as much as did the location and the pattern of arterial feeding. Thus, a large AVM (greater than or equal to 4 cm) was given 2 points; a small AVM (less than 4 cm) was given 0 points; a deep AVM was given 1 point; a superficial AVM was given 0 points; an AVM supplied by three of more artery systems was given 1 point; and an AVM supplied by one or two artery systems was given 0 points. AVMs were categorized into 5 grades from Grade 0 to 4 by the summation of these points. Predicted Karnofsky scale after surgery was calculated by this grading system and the following equation: predicted Karnofsky scale = 87.2 - 5.6 x Grade. Grade 0 and 1 AVMs showed high rates of total excision (Grade 0, 94%; Grade 1, 82%) and of satisfactory outcome (Grade 0, 90%; Grade 1, 82%) and were classified as "easy" lesions. Grade 2 AVMs are lesions classified as "moderate" and had a total excision rate of 76% and a satisfactory outcome rate of 71%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1990

The association of arteriovenous malformation and aneurysm within the posterior cranial fossa--report of a case.

A relatively rare case of cerebellar arteriovenous malformation (AVM) associated with a saccular aneurysm fed by the left posterior inferior cerebellar artery (PICA) is described. The interpretation of angiograms and the appropriate surgical treatment for the coexistence of the intracranial AVM and aneurysm are discussed. It is a fact that the steal phenomenon existed in the flow of contrast medium during the angiography. The appropriate surgical treatment may be clipping of the aneurysmal neck first and then radical excision of the AVM.

Adult↗
PubMed1990

The pattern of diabetes in a primary health care setting in Singapore.

This is a study of Diabetes mellitus and its treatment in a single doctor government primary health care clinic in Singapore. Data was collected on the entire 349 patients with diabetes attending this clinic over a three month period in 1987. We found there was an increasing number of diabetics with age and a substantial proportion was above 70 years of age. Only 7% had their diabetes treated with diet alone and 9.6% were treated with insulin. Most (61%) patients were on tolbutamide, with 17.6% on glibenclamide and 5.9% on chlorpropamide. Hypertension was found in 38% of the diabetic patients but was not associated with increase in age of the patient. The duration of diabetes, but not the age of the patient, was positively associated with the number of drugs taken by the patient (chi-squared, p less than 0.05).

Adolescent↗