Biomedical subjects

T K McKone

Publications and source records attributed to T K McKone.

4 recordsLinked to original sources

PubMed1988

Pancreaticoduodenectomy for trauma: a life-saving procedure.

The purpose of this report is to examine our experience with pancreaticoduodenectomy for trauma in a community trauma center. Five patients underwent pancreaticoduodenectomy for severe combined injury to the pancreas and duodenum from July 1980 to December 1986. All five patients survived. The average age of the patients was 29 years. Four patients sustained blunt trauma and one sustained penetrating trauma. The average length of operation was 5 hours. There was an average of two injured organs per patient in addition to pancreatic and duodenal injuries. The average hospital stay was 24 days. Two patients had postoperative complications requiring reoperation. All patients were discharged tolerating oral feedings without the need for insulin or pancreatic exocrine supplements. This report confirms the utility of pancreaticoduodenectomy for severe combined pancreatic and duodenal trauma.

Adult↗

PubMed1987

Primary appendiceal adenocarcinoma.

Primary appendiceal adenocarcinoma is rare, with fewer than 300 reported cases. This report reviews 23 cases of appendiceal adenocarcinoma at Butterworth Hospital from 1968 to 1985. Clinical presentation, operative findings, treatment, and length of survival were recorded. Common clinical presentations included acute appendicitis and progressive abdominal distention. This disease was frequently an incidental finding during unrelated elective surgery and was often associated with other primary malignancies. Surgical treatment included appendectomy, right hemicolectomy, and interval hemicolectomy after initial appendectomy. Improved survival was noted in patients who had localized and noninvasive disease. Prognosis was most closely related to tumor grade. No patient who had localized, well-differentiated tumor died from the disease or had evidence of tumor recurrence after surgical treatment. All patients with poorly differentiated tumors died from widespread carcinomatosis. Appendectomy appears to be sufficient treatment for well-differentiated, localized, mucus secreting adenocarcinomas of the appendix.

Adenocarcinoma↗

PubMed1985

Fibronectin. A new nutritional parameter.

Acute and chronic malnutrition is associated with increased morbidity and mortality in surgical patients. Plasma fibronectin levels have been shown to correlate with reticuloendothelial function and are reduced in burns, shock, trauma, and sepsis. Patients failing to show an increase in fibronectin levels after stress have been shown to do poorly. Starvation studies in human volunteers have demonstrated decreasing plasma fibronectin levels until feeding was resumed. The purpose of this study is to examine the usefulness of fibronectin as an assessment parameter in nutritionally depleted hospitalized patients. Eight patients initiated on parenteral nutrition were studied. Plasma fibronectin, albumin, and transferrin levels were drawn before TPN and repeated at various intervals after total parenteral nutrition (TPN) was begun. Mean pre-TPN transferrin was 198.1 +/- 16.1 gm/dl (nl 220-400). Transferrin levels remained statistically unchanged after 8 to 11 days of TPN. Mean pre-TPN albumin was 3.0 +/- 0.2 gm/dl (nl 3.6-4.8) and also remained statistically unchanged after 8 to 11 days of TPN. The mean fibronectin level pre-TPN was 236.4 +/- 24.4 microgram/ml (nl 370-410). Fibronectin rose statistically (P less than 0.005) after 1 to 4 days of TPN to a mean of 341.9 +/- 30.1 microgram/ml and remained elevated and statistically unchanged after 8 to 11 days of TPN. Six of the eight patients studied survived and had demonstrated at least a 30 per cent increase in fibronectin after 1 to 4 days of TPN. Both patients who died demonstrated minimal increase in fibronectin levels after 1 to 4 days of TPN.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1981

Hemodynamic effects of military anti-shock trousers (MAST) in experimental cardiac tamponade.

The ability of military anti-shock trousers (MAST) to increase central venous pressure and improve cardiac filling pressure suggests that they might be useful in the prehospital treatment of pericardial tamponade. This study utilizes a canine model to examine the hemodynamic effects of MAST inflation on experimentally induced pericardial tamponade. Use of the MAST garment improved cardiac filling, mean arterial pressure, and cardiac output in the decompensated tamponade state. It should be realized that animal data may not correlate with human clinical response.

Animals↗