Biomedical subjects
T K Trubitsyna
Publications and source records attributed to T K Trubitsyna.
[Comparative anorexigenic activity and other pharmacological properties of quipazine and its N-acyl derivatives].
In experiments on mice and rats quipazine exerts a moderate and short-term anorexigenic activity. N-acyl quipazine derivatives are markedly less toxic, do not exert anorexigenic action and influence weakly the serotoninergic and adrenergic systems.
[Group toxicity of indopan and its reaction to various neurotropic drugs].
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[Pharmacological properties of some tryptamine homologues].
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[Pharmacological properties of indolylalkyl derivatives of quipazine].
Pharmacological activity of the indolylalkyl derivatives of quipazin has been studied. 1-3(-Indolylmethyl)-4-(2"-quinolyl) piperazine dimaleate has proved to be the most active according to the tests used for examining the properties of quipazin. Like quipazin, it produces the contracture of smooth muscle organs and bronchospasm. It has a constrictive effect of the vessels, elicits central serotonin-positive actions, reduces the effect of reserpine and tetrabenazine, potentiates the central effects of amphetamine and L-DOPA. The drug does not affect the convulsant action of tryptamine in rats. Unlike imipramine, it shows no cholinolytic activity. Elongation of the methylene chain that connects the indole residue and the quipazin molecule leads to a decrease in the pharmacological activity.