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Biomedical subjects

T KOPPANYI

Publications and source records attributed to T KOPPANYI.

At least 19 recordsLinked to original sources

Reversal of phenylalkylamine tachyphylaxis by norepinephrine.

Since the responses to "neurosympathomimetic amines" are reduced in the reserpinized animal and restored by norepinephrine administration, it was postulated that norepinephrine might also affect the development of their tachyphylaxis. We found that norepinephrine infusion restored, at least partially, certain tachyphylactic responses to amphetamine or ephedrine and fully prevented the development of tachyphylaxis to tyramine.

Amines↗

Newly found action of cocaine.

Cocaine augments appreciably the effects of small doses of acetylcholine on the heart rate, blood pressure, and the nictitating membrane in intact, anesthetized animals. This phenomenon assigns cocaine, thus far only known as a potentiator of adrenergic stimulation, a more general role of potentiator of both adrenergic and cholinergic neurohumors.

Acetylcholine↗