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Biomedical subjects

T Kado

Publications and source records attributed to T Kado.

At least 19 recordsLinked to original sources
PubMed1994

[A case of UIP with autoimmune hemolytic anemia].

A 70-year-old male was admitted because of cough and sputum. Chest X-ray showed bilateral interstitial shadows, and usual interstitial pneumonitis was diagnosed by TBLB and BAL. He was followed without medication. The dyspnea increased and the abnormal shadow spread on chest X-ray. Autoimmune hemolytic anemia was newly diagnosed because the RBC count was 195 x 10(4)/mm3, Hb was 8.6 g/dl, and direct Coombs test and warm antibody were positive. In this case, there appears to be a relationship between deterioration of interstitial pneumonia and the on-set of autoimmune hemolytic anemia.

Aged↗
PubMed1993

Studies of a key protein in the mechanism of the excitation-contraction coupling process of frog skeletal muscle, using phenylglyoxal.

The excitation-contraction (E-C) coupling process in single twitch fibres from frog toe muscle was inhibited selectively by phenylglyoxal (PGO), a specific guanidyl modifying reagent. A new protein (31.5 kDa), which has PGO-binding ability and seems to play a key role in the E-C coupling process, was solubilized from transverse tubule membrane-junctional sarcoplasmic reticulum complexes (TTM-JSR) of frog skeletal muscles, using 14C-PGO. The monoclonal antibody against this protein applied extracellularly inhibited the E-C coupling process of the single fibres. This protein appears to constitute the very first step of input for E-C coupling. It is considered to behave as an indispensable part of an 'electrometer' to measure membrane potentials. Therefore, the name 'electrometrin' is suggested for the new protein.

Animals↗
PubMed1991

[Small sized non-small cell lung cancer in advanced stage].

Eighteen cases of non-small cell, small sized advanced lung cancer, out of 362 operated cases for 6 years excluding 7 cases of small cell lung cancer, 60 of preoperative treated and 27 of inoperable cases, were discussed. A small sized tumor was defined as a tumor within 8,000 mm3 in its volume, calculated by multipling three lengths measured on the resected specimens. There were fourteen cases with stage 3 and 4 (A), and four cases with N1 disease (B). In group A, three cases of twelve with N2 diseases showed the tiny skipping lesion in the mediastinum with negative regional nodes. Remaining two had a lesion of dissemination and pulmonary metastasis. In group B, they showed unusual way of N1 spread, in which two of them with left upper lobectomy had metastatic lymph nodes on the non-bearing lobe, the lower lobe, and other two cases took regional lymph nodes metastasis without invasive growth of the main tumor. Predominant histologic type was adenocarcinoma, but the subtype and the differentiation of it were not specific. The level of CEA was low below 5 ng/dl in most of them except three cases, in which it suggested massive positive nodes and pulmonary metastasis. Seven patients died of the disease in two years. Remainders are alive, 4 with and 7 free from the tumor with the longest period of 3 years and a half. N2 diseases of small sized tumor were found in the cases with the volume of 3 cm3 and more at almost same ratio.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

Hematoma of the interatrial septum associated with complete atrioventricular block.

A 70-year-old man who had been treated for tongue cancer began to suffer from repeated syncopal attacks. His electrocardiogram indicated complete atrioventricular block. A permanent pacemaker was implanted. He was well for about 2 years after which time he developed dyspnea, suffered from general fatigue, and then suddenly died. A postmortem examination revealed a hematoma approximately 4 x 4. cm in size in the interatrial septum, connected to a noncoronary sinus and rupture of the noncoronary leaflet, which compressed the tricuspid and aortic valves. This hematoma might have been related to the conduction disturbance caused by destructive compression on the conduction system, and his death by the rupture of the noncoronary leaflet.

Aged↗
PubMed1986

Time lag between pulmonary congestion and pulmonary edema in dogs.

The time course of pulmonary congestion and pulmonary edema was examined using a gravimetric method in 19 open-chest anesthetized dogs. Balloon catheters in the left atrium (LA) were inflated to elevate LA pressure more than 25 mmHg. The dogs were divided into 4 groups (G) according to the duration of the elevated LA pressure: G.1 (n = 6) as control; G.2 (n = 4) for 15 minutes; G.3 (n = 4) for 30 minutes; and G.4 (n = 5) for 60 minutes. Although no significant increase of extravascular lung water content (an indicator of pulmonary edema) was observed in G.2 (4.97 +/- 0.85 g/kg) and G.3 (4.46 +/- 0.96) compared with G.1 (4.02 +/- 0.88), a significant increase was observed in G.4 (6.81 +/- 1.21, p less than 0.05). Residual pulmonary blood content (an indicator of pulmonary congestion) was significantly increased in G.2, 3 and 4 compared with G.1. By light and electron microscopes, pulmonary congestion was revealed in G.2, whereas interstitial pulmonary edema was demonstrated only in G.4. Thus, it was concluded that pulmonary congestion occurred within 15 minutes, but pulmonary edema occurred 30 to 60 minutes after left atrial pressure was elevated more than 25 mmHg. This time lag may be an important factor in explaining the discrepancy between the elevated left atrial pressure and the clinical manifestation of pulmonary edema.

Animals↗
PubMed1984

Mixed connective tissue disease with fatal pulmonary hypertension and a review of literature.

The paper presents an autopsy case of mixed connective tissue disease (MCTD) with pulmonary hypertension (PH) and a review of literature. A 33-year-old woman with Raynaud's phenomenon and dyspnea of one year duration was diagnosed as having MCTD on the basis of a higher titer (1:163,840) of serum antibodies to the ribonucleoprotein (RNP). Cardiac catheterization showed complicating PH, confirmed an autopsy by the findings of concentric intimal cellular proliferation and typical plexiform lesions in the small arteries and arterioles of the lung, suggesting primary PH. Fatal PH with MCTD has been reported only 6 cases in literature including our case. All were young females, with histopathological findings consistent with plexogenic pulmonary arteriopathy in 5 cases and with recurrent pulmonary thromboembolism in the other. The aetiology of PH is still unknown, but it may be due to vasoconstriction evoked by the hyper-reactivity of the vessels.

Adult↗