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Biomedical subjects

T Kashimoto

Publications and source records attributed to T Kashimoto.

At least 73 records · Page 4Linked to original sources
PubMed1984

Causal agents of yusho.

Through the analysis of polychlorinated biphenyls (PCBs), polychlorinated quaterphenyls (PCQs), and polychlorinated dibenzofurans (PCDFs) retained in the blood of Japanese and Taiwanese patients who had been poisoned by ingesting contaminated cooking oils, in the blood of workers occupationally exposed to PCBs, and in the blood of unexposed individuals, it was strongly suggested that PCDFs might be the responsible compounds for the development of yusho disease. To confirm this, animal experiments were done. The dermal signs resembling those of yusho were observed among the cynomolgus monkeys that received a PCDF mixture consisting of PCDF components similar to those in the yusho oils. In addition, significant thymic atrophy and decreased body weight gain were noted in the rats fed PCDFs. However, the administration of PCBs or PCQs alone failed to cause such signs in the monkeys or rats. As a result, it became clear that PCDFs were the main causative agents in the pathogenesis of yusho disease.

Adipose Tissue↗
PubMed1984

Causal agents of yusho.

Through the analysis of polychlorinated biphenyls (PCBs), polychlorinated quaterphenyls ( PCQs ), and polychlorinated dibenzofurans ( PCDFs ) retained in the blood of Japanese and Taiwanese patients who had been poisoned by ingesting contaminated cooking oils, in the blood of workers occupationally exposed to PCBs, and in the blood of unexposed individuals, it was strongly suggested that PCDFs might be the responsible compounds for the development of yusho disease. To confirm this, animal experiments were done. The dermal signs resembling those of yusho were observed among the cynomolgus monkeys that received a PCDF mixture consisting of PCDF components similar to those in the yusho oils. In addition, significant thymic atrophy and decreased body weight gain were noted in the rats fed PCDFs . However, the administration of PCBs of PCQs alone failed to cause such signs in the monkeys or rats. As a result, it became clear that PCDFs were the main causative agents in the pathogenesis of yusho disease.

Animals↗
PubMed1984

Effects of nicardipine and other Ca2+-antagonists on catecholamine transport into chromaffin granule membrane vesicles.

Nicardipine (10(-7)-2 X 10(-5) M) inhibited the transport of noradrenaline into chromaffin granule membrane vesicles in a concentration-dependent manner. This inhibitory effect of nicardipine was found to be appreciably stronger than that of other Ca2+-antagonists(diltiazem, nifedipine and verapamil) and was not due to the blockade of Ca2+-channel in the granule membranes.

Animals↗
PubMed1982

Effect of polychlorinated biphenyls and polychlorinated quaterphenyls in Cynomolgus monkey (Macaca fascicularis).

Female Cynomolgus monkeys (Macaca fascicularis) with P-KC-400, Y-PCB, PY-PCB or polychlorinated quaterphenyls (PCQ) received a daily dose of 5 mg for 20 weeks, and some monkeys received a daily dose of 10 mg of Y-PCB or 0.5 mg of PCQ. The chemical compositions of the polychlorobiphenyls (PCB) used for the oral administration were as follows: P-KC-400, PCB from which polychlorodibenzofurans (PCDF) have been removed from Kanecklor 400, largely contains tri- and tetrachlorobiphenyls and no PCDF. Whereas, Y-PCB and PY-PCB, PCB with constituents similar to PCB ingested by yusho patients, largely contain penta- and hexachlorobiphenyls, in addition, PCDF of 400 ppm was present only in Y-PCB, but not in PY-PCB. There were immunosuppression, enlargement and histopathological changes of the liver (such as interstitial inflammation, and proliferation of epithelial cells of biliary duct, etc.) in the groups fed P-KC-400 and PY-PCB (free of PCDF). In the group fed Y-PCB (with PCDF), there were more apparent decreases in body weight, immunosuppression, fatty liver and histopathological changes than in the groups P-KC-400 and PY-PCB. In addition, there were hair loss, acneform eruptions, edema of the eyelid, congestion and abscess of the Meibomian gland, and cornifications of the skin, characteristic dermatological findings of yusho disease.

Animals↗
PubMed1982

Anatomical and biomechanical factors in the curve pattern formation of idiopathic scoliosis.

The maximum range of motion between two adjacent vertebrae without soft tissues was measured from C1-C2 down to L5-S and factors such as rotation, lateral bending, extension, and flexion, during surface contact movement of the facet joints, were investigated. Thirty human cadaveric spines were studied. It was found that the individual spines had a characteristic level-dependent difference in the capacity for elementary motions at the facet joints. Those segments with restricted motion capacity were termed "spinal nodes". The human spine usually has three to four spinal nodes between the skull and the sacrum. They are C7-T1, T4-T5, T8-T9, and T11-T12. This intrinsic structural character of the human spine is expressed as "nodal motion structure". We postulate that this structure plays an important role in the formation of curve patterns in idiopathic scoliosis and other spinal deformities.

Adult↗
PubMed1980

Effects of cyclopropane on catecholamine release from bovine adrenal medulla.

The direct effects of cyclopropane on both adrenal medullary release of catecholamines and release of catecholamines from isolated chromaffin granules were examined. Cyclopropane had no effect on the spontaneous release of catecholamines from perfused bovine adrenals, while it reversibly inhibited carbachol-induced release of catecholamines in a dose-dependent manner. At 20 per cent cyclopropane, catecholamine release was reduced to 52 per cent of control. Cyclopropane exerted no action on spontaneous release or Mg++-ATP-dependent release of catecholamines from isolated chromaffin granules. Thus, the authors conclude that the direct action of cyclopropane on the adrenal medullary release of catecholamines is inhibitory, and that chromaffin granules are not the site of action of this anesthetic.

Adenosine Triphosphate↗