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Biomedical subjects

T Kasuga

Publications and source records attributed to T Kasuga.

At least 145 records · Page 8Linked to original sources
PubMed1983

Relation between Friend leukemia virus-induced leukemia and genetic control of the host.

Hematological assays of inbred specific pathogen-free (SPF) mice of ten different strains inoculated with Friend leukemia virus (FLV) were performed chronologically to assess whether the genetic control of the host may play an important role in viral oncogenicity. Mice strains C57BL/6J, B10 (H-2b) and B10D2 (H-2d) were FLV-resistant, BALB/c, DBA/2N (H-2d), RFM (H-2f), AKR and 80% of CBA/JN (H-2k) were FLV-sensitive (polycythemia) and C3H/He, B10Br and 20% of CBA/JN (H-2k) were FLV-sensitive (anemia). Only the AKR strain mice showed a spontaneous regression of splenomegaly. These results indicate that there is not a strong but a weak correlation between the H-2 haplotype and the reaction to FLV. The main phenomenon in the anemic mice was the monotonous proliferation of the naked blastic cell, whereas that in the polycythemic mice was the enormous increase of the mature erythroblast and the decrease of the naked blastic cell in the later phase. These facts suggest that the naked blastic cell in the mice with polycythemia are reactive and that in the mice anemia truly neoplastic.

Anemia↗
PubMed1983

[Autopsy case of atypical medulloblastoma in an adult].

A 24-year-old female complained of headache and vomiting. The brain-CT scan demonstrated a tumor shadow in the right cerebellar hemisphere. The tumor was partially resected, and irradiation therapy was started. She died of intraventricular hemorrhage about 6 months after the onset of symptoms. Autopsy revealed a recurrent tumor mass in the cerebellum extending to the brain stem. It showed systemic metastases to the leptomeninx, liver, bones and ovaries. Histological examination showed a tumor which was a primarily composed of typical medulloblastoma cells with occasional Homer-Wright type rosettes. It partly showed glioblastoma-like configuration. Some tumor cells were positive for GFAP by the PAP method, suggesting glial differentiation.

Adult↗
PubMed1983

[Case of carcinoid tumor of the breast].

A 74-year-old female with a left breast mass was admitted to the Cancer Institute Hospital and underwent mastectomy. Upon study of a frozen section, a diagnosis of breast carcinoma was made. Histopathological examination revealed a non-invasive tumor whose slightly eosinophilic rich cytoplasm was positive for PAS and Alcian-green staining and argyrophilic staining. The tumor showed medullary arrangement, partly with glandular and rosette-like structures. Electron microscopically, many dense core granules (170 +/- 30 nm in diameter) were diffusely distributed in almost all the tumor cytoplasm, they were thought to be neurosecretory granules. A diagnosis of mucocarcinoid of the breast was made. The patient experienced no dyshormonal disorder during the course of the disease and is alive and well without recurrence.

Aged↗
PubMed1983

[Visceral metastasis in 135 cases of breast cancer: evaluation at autopsy].

We examined the distribution and frequency of metastasis in 135 breast carcinoma cases autopsied between 1946 and 1981 at the Cancer Institute, Tokyo, and studied the relationship between the results and various factors such as histological type, patient age, therapy and clinical course. Breast carcinoma metastasizes more widely and more frequently than other malignant tumors; there is a high rate of metastasis to the bone, adrenals, opposite breast, and thyroid. Medullary tubular carcinoma metastasizes more highly than other histological types. The frequency of metastasis is higher in the younger age group and in patients irradiated to the primary sites. There is little correlation between the frequency of metastasis and total duration.

Adult↗
PubMed1983

Difference in 3H-thymidine incorporation after irradiation between murine B16 melanoma and squamous cell carcinoma in vivo.

The tumor growth and cell proliferation kinetics of B16 melanoma and transplantable squamous cell carcinoma (BSC tumor) in C57BL/6 mice were studied after single-dose X-ray and fast-neutron (2 MeV) irradiations. From tumor volume change studies, B16 tumor showed a high relative biological effectiveness (RBE) value (5.5) compared to that of BSC tumor (3.5). The tissue characteristics of the two tumors were not significantly different, but the post-irradiation changes in mitotic index (MI) and lebeling index (LI) were dependent on the tumor and on the nature of the radiation. After irradation, mitosis was immediately inhibited (G2 block) but recovered within several hours in BSC and X-ray-irradiated B16 tumors. The neutron-irradiated B16 tumors showed no recovery up to the end of the observation period. After X-ray irradiation, of B16 tumors, LI showed an immediate reduction, while the reduction was delayed several hours (equal to G1 + M) in BSC tumors. The extent of reduction was dose-dependent, and its recovery was coincident with the recovery of mitosis. The change in LI of neutron-irradiated BSC tumors was similar to that with X-rays, but no change in LI was observed in neutron-irradiated B16 tumors over 18 hr. From these results, it is assumed that the cell progression of B16 tumors is susceptible to ionizing radiation, and that G1 block is induced as a result of irradiation.

Animals↗
PubMed1982

Induction of pigmentation by continuous X-irradiation of amelanotic tumors of B16-XI mouse melanoma and induced change in chromosomes of amelanotic cells.

Non-pigmented tumor cells of B16-XI mouse melanoma were found to contain a diploid number of chromosomes similarly to those of melanotic tumors and the parental cells in tissue culture. A major difference between pigmented and non-pigmented cells was in the number of biarmed chromosomes per cell. There was no difference in growth rate between non-pigmented and pigmented tumors, but growth usually begins about 2 days earlier in the former. Pigmentation lost in the course of serial transplantation was restored by irradiating the non-pigmented tumor continuously with 2,500-3,000 rads/passage of X-rays during six transfer generations. In the course of repeated irradiations, the chromosomes changed structurally and numerically as the pigmentation of the tumor was gradually restored. The observations of tumor growth and chromosomal changes are discussed in relation to the pigmentation of B16-XI melanoma cells.

Animals↗
PubMed1982

Mucoepidermoid carcinoma of the thymic region.

A case of mucoepidermoid carcinoma in thymus in a 59-year-old Japanese female is presented. She died of cardiac tamponade due to tumor invasion ater a 5 years' clinical course. At autopsy the main tumor was found in the thymic region with metastases to the sternum, regional lymph nodes, pericardial, and left pleural cavity. The mucoepidermoid carcinoma might be probably originated from a hen's egg-sized cyst which was located in the upper posterior aspect of the tumor-involved thymus. No teratomatous components were present. The cyst was most likely to be of thymic or bronchogenic cyst origin, though it was not determined, in view of the lining with pseudostratified ciliated columnar epithelium of the cystic wall and the surrounding with the thymic tissue outside. Moreover, there was thymic hyperplasia with germinal center that was compatible with SLE-like symptoms in her past history and autoimmune nature of the autopsy findings of pulmonary fibrosis.

Carcinoma↗
PubMed1982

Effect of irradiation with fast neutrons or X-rays on the incidence of metastasis of transplanted B16 melanoma in mice.

The effects of X-rays and fast neutrons on the incidence of metastasis of B16 melanoma were investigated. Tumors were irradiated with the iso-effect dose (380 rad of 2 MeV fast neutrons, and 1900 rad of 200 kV X-rays) for regression and regrowth of the tumor, and then were excised 3 days after irradiation. Metastasis was examined macroscopically and microscopically in all organs and tissues of mice when death occurred or after sacrifice of surviving mice at 130 days after tumor inoculation. Metastasis was found in 16 to 22% of tumor-bearing mice irrespective of whether or not the tumor had been irradiated before excision. Almost all the mice with metastasis developed pulmonary metastasis accompanied by lymphogenous spread to the thoracic lymph node. The overall incidence of metastasis in the X- or fast neutron-irradiated mice was slightly but not significantly higher than that in the control mice. Irradiation significantly enhanced the incidence of metastasis when the tumor volume was smaller than 200 mm3, but not when the tumor volume was larger than 200 mm3. The incidence of metastasis was significantly enhanced in mice with tumors invading the muscle. The metastasis-enhancing effect of irradiation was noticeably greater with X-irradiation than with fast neutron irradiation in mice with localized tumors of B16 melanoma, whereas in mice with invasive tumors the effects were similar.

Animals↗
PubMed1981

Diagnostic usefulness of 201Tl-chloride scintigraphy for preoperative localization of parathyroid tumors.

201Tl-chloride scintigraphy was performed in 10 patients with hyperparathyroidism to assess the localization of abnormal parathyroid glands. This approach proved to be useful in 8 of 10 patients. In particular, an intramediastinal ectopic gland was clearly demonstrated in one patient. Several disadvantages were noted, however, 201Tl-chloride scintigraphy could be the first choice for preoperative localization of abnormal parathyroid glands. If a negative image is obtained, further examinations such as arteriography or parathyroid hormone assay be selective venous blood sampling should be done.

Adult↗