Biomedical subjects

T Kinugawa

Publications and source records attributed to T Kinugawa.

75 records · Page 5Linked to original sources

PubMedDate not supplied

A case of Cushing's disease and multiple myeloma.

A 55-year-old female of Cushing's disease associated with multiple myeloma is reported. The association of the two diseases has not been previously noted. Elevated cortisol level was controlled successfully by low doses of adrenocorticolytic agent, o,p'-DDD. However, the exacerbation of multiple myeloma was found to accompany the serum cortisol normalization. Previous reports have shown the good efficacy of combination therapy with melphalan and prednisolone for multiple myeloma. It was suggested that the decrease of endogenous cortisol level might exacerbate the patient's multiple myeloma.

Cushing Syndrome↗

PubMedDate not supplied

Cardiac neurosis: exercise tolerance and the role of sympathetic activity.

To evaluate the cardiovascular and plasma catecholamine responses to dynamic exercise in patients with cardiac neurosis (CN), treadmill testing was performed. Thirty-four patients with CN were chosen for this study based on exercise tolerance and the results were compared with those in 31 patients with organic heart disease and 12 normal subjects. Patients with CN showed an augmentation of cardiovascular and plasma catecholamine responses. The augmentation of the norepinephrine response in patients with CN was not as remarkable as that in patients with organic heart disease. On the other hand, the augmentation of the epinephrine response was greater in patients with CN than in those with organic heart disease. Administration of metoprolol (40 mg/day) for two weeks improved exercise tolerance in patients with CN. We suggest that anxiety augments both sympatho-neural and sympatho-adrenal activity and that it is the symptoms induced by the augmented cardiovascular response which reduce exercise tolerance in patients with CN.

Adult↗

PubMedDate not supplied

Effects of guanabenz acetate on the pacemaker activity of rabbit sinoatrial node cells.

The effects of guanabenz acetate on the electrophysiological properties of isolated rabbit sinoatrial node were studied using conventional microelectrode and double-microelectrode voltage clamp methods and were compared with those of clonidine and guanethidine. In spontaneously beating sinoatrial node preparations, guanabenz decreased the heart rate, the maximum rate of rise (Vmax), the action potential amplitude and the rate of diastolic depolarization in a dose-dependent fashion, whereas the action potential duration at 50% repolarization was prolonged. In comparison with clonidine and guanethidine, the inhibitory potency of guanethidine on the heart rate is weaker than that of guanabenz and clonidine. On the current systems, the voltage clamp experiments showed that guanabenz reduced the slow inward current and the time-dependent potassium outward current. These observations indicate that guanabenz acts directly on cardiac tissues and its bradycardic action can be mainly explained by a reduction of delayed current systems.

Action Potentials↗