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T Kitayama

Publications and source records attributed to T Kitayama.

At least 19 recordsLinked to original sources
PubMed1995

[Vasodilating effects of NY-008 in ring preparation of rat aorta].

Vasodilating effects of NY-008 were compared to those of verapamil in isolated rat aorta. NY-008 at the dose of 3 x 10(-5) M relaxed 10-70 mM potassium chloride (KCl)-induced contraction. NY-008 relaxed preparations precontracted with 60 mM KCl concentration-dependently with an IC50 of (6.17 +/- 1.75) x 10(-6) M, and those precontracted with norepinephrine (NE) (10(-6) M) concentration-dependently, maximally by 90.0 +/- 2.86%, with an IC50 of (2.06 +/- 0.38) x 10(-5) M. At 10(-8)-3 x 10(-6) M, verapamil relaxed preparations precontracted with NE (10(-6) M) concentration-dependently, maximally by 55.9 +/- 5.56%. At 3 x 10(-5) M and 10(-4) M, NY-008 relaxed (10(-6) M)-induced phasic contractions in a Ca(2+)-free 1 mM EGTA-containing buffer, by 22.4 +/- 3.69% and 35.4 +/- 5.74%, respectively. In contrast, 3 x 10(-7) M verapamil did not. NY-008 concentration-dependently decreased the maximal responses to calcium chloride (CaCl2) in 60 mM KCl-depolarized preparations, and it shifted the ED50 values of CaCl2 to the right, whereas verapamil shifted the ED50 values of CaCl2 to the right without decreasing the maximal responses to CaCl2. At 10(-5)-3 x 10(-4) M, NY-008 concentration-dependently relaxed preparations precontracted with prostaglandin F2 alpha (10(-5) M) in a Ca(2+)-free, 0.5 mM EGTA-containing buffer, whereas 10(-7)-10(-5) M verapamil did not. These results suggest that NY-008 antagonized Ca2+ and decreased the Ca(2+)-sensitivity of contractile elements or inhibited contractile proteins in rat aorta.

Animals↗
PubMed1993

[Measurement of serum insulin-like growth factor-I by enzyme-linked immunosorbent assay in uremic patients and uninephrectomized patients].

Using the enzyme-linked immunosorbent assay (ELISA), we determined the serum insulin-like growth factor-I (IGF-I) levels in the patients on hemodialysis and patients who had undergone unilateral nephrectomy. This ELISA system was able to detect IGF-I over the range of 1.6 to 50 ng/ml. The serum IGF-I levels in 45 male and 34 female dialytic patients (12.7 +/- 7.4 ng/ml and 29.0 +/- 15.9 ng/ml) were significantly low (P < 0.01) compared with 50 normal adult men and 53 normal adult women (34.9 +/- 11.4 ng/ml and 44.5 +/- 20.5 ng/ml). The serum IGF-I level tended to decrease with aging. Furthermore, we determined the IGF-I levels in 5 donors for living-related kidney transplantation and 7 patients with upper urinary tract tumor before and after unilateral nephrectomy in order to examine the endocrine effect of IGF-I. The IGF-I level in the donors decreased significantly (P < 0.05) on the fifth postoperative day and returned to the preoperative level on the 14th postoperative day. The IGF-I level in the tumor patients decreased significantly on the fifth postoperative day (P < 0.01) and remained at a low level up to the 14th postoperative day. However, the changes in the postoperative IGF-I level in the patients who had undergone surgical operations other than unilateral nephrectomy showed patterns similar to those in the kidney transplantation donors. These findings suggest that the postoperative fall in the serum IGF-I is affected by either fasting after surgery or consumption due to healing of the operative wound.

Adult↗
PubMed1990

[A case of secondary bladder tumor the origin (gastric cancer) of which could not be identified before autopsy].

Primary bladder tumor is the most frequent malignant tumor in the field of urology, whereas the incidence of secondary bladder tumor from a distant organ is quite rare. We report here a 21-year-old female patient with metastatic bladder tumor from gastric cancer. She came to our hospital with a complaint of only bladder irritability. Cystoscopical and cytological examinations revealed rhabdomyosarcoma of the bladder. She did not respond to radiation therapy and combined chemotherapy, consisting of actinomycin D, vincristine and cyclophosphamide, and died 91 days after admission. Autopsy revealed a primary tumor of poorly differentiated scirrhus carcinoma of the stomach. Thus this was a quite rare case of metastatic bladder carcinoma characterized by bladder irritability without gastrointestinal symptoms.

Adenocarcinoma, Scirrhous↗
PubMed1990

[A case of primary localized amyloidosis of the urinary bladder].

A case of primary localized amyloidosis is reported. The patient was a 73-year-old female who suffered from miction pain and consulted our department. There was a 1.5 x 1.5 cm slightly red, nonpapillary tumor around the right ureteral orifice in cystoscopy. The diagnosis was amyloidosis with cystitis hemorrhagica histopathologically. After the treatment with antibiotics for about one month there were no symptoms and no tumors in the urinary bladder cystoscopically. The clinical course was relatively good. The treatment varies from transurethral resection to total cystectomy with urinary diversion. This case was cured by non-operative treatment, but close follow-up of the patient is necessary because of the frequency of multiple recurrence.

Aged↗
PubMed1990

[A case of renal subcapsular hematoma caused by paravertebral muscular injection of local anesthetics].

We report a case of left renal subcapsular hematoma caused by paravertebral muscular injection of acetylcholine chloride for the treatment of lumbago in a 42-year-old man. Since the patient suffered from left lumbago after paravertebral muscular injection, he consulted us. Excretory pyelography showed a left poor visualizing kidney and computed tomography demonstrated left renal subcapsular hematoma. Conservative treatment was done. After two weeks, drip intravenous pyelogram was normal and after four months computerized tomographic scan demonstrated no renal subcapsular hematoma. The main causes of renal subcapsular hematoma are renal injury, nephritis, renal tumor and renal biopsy. Renal subcapsular hematoma caused by paravertebral muscular injection is rare and three cases of hematoma including this case have been reported in the Japanese literature.

Acetylcholine↗
PubMed1987

Spontaneous regression of an intrarenal arteriovenous malformation.

We report a case of spontaneous regression of a right intrarenal arteriovenous malformation 6 months after initial examination without surgical intervention, arterial embolization or radiotherapy. The patient presented with massive hematuria from the right kidney, which disappeared completely after spontaneous regression.

Arteriovenous Malformations↗
PubMed1987

Inhibitory effect of beauvericin on a high K+-induced tonic contraction in guinea-pig taenia coli.

An inhibitory effect of beauvericin, a cyclodepsipeptide, on a high K+-induced contraction in guinea-pig taenia coli was compared with those of verapamil, an organic Ca2+ antagonist, and monensin, an inhibitor of mitochondrial respiration. Beauvericin (10(-5) M), verapamil (5 x 10(-7) M) or monensin (10(-6) M) markedly inhibited the tonic contraction, while these drugs showed less effect on the phasic contraction. Beauvericin at a lower concentration (10(-6) M) competitively inhibited the Ca2+-induced contraction in depolarized muscle, whereas higher concentrations (3 x 10(-6) or 10(-5) M) non-competitively inhibited this contraction. Verapamil (10(-8)-5 x 10(-7) M) competitively inhibited and monensin at a low concentration (10(-7) M) non-competitively inhibited this contraction. A contraction induced by 0.5 mM Ca2+ was inhibited by beauvericin with an IC50 (concentration needed for 50% inhibition) of 2.8 x 10(-7) M, verapamil with an IC50 of 2.9 x 10(-8) M, and nifedipine with an IC50 of 1.8 x 10(-9) M. 10(-6) M CGP 28392, a Ca2+ channel facilitator, increased the IC50 of beauvericin, verapamil or nifedipine. Although the inhibitory effect of monensin (10(-7)-10(-6) M) on the high K+-induced contraction was reduced under hypoxia, the effects of beauvericin (10(-7)-10(-5) M) and verapamil (10(-8)-10(-7) M) were not modified. Beauvericin (10(-5) M) changed neither the intracellular Na+ and K+ contents of the depolarized muscle nor the Ca2+-induced contraction in the chemically skinned taenia coli.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1986

Acute hemorrhagic cystitis caused by adenovirus type 11 after renal transplantation.

A case of acute hemorrhagic cystitis caused by adenovirus type 11, which occurred in an allograft recipient 6 months after a living-related renal transplantation, is described. The patient lacked a neutralizing antibody to adenovirus type 11 before transplantation. Adenovirus type 11 was isolated from his urine and he developed a neutralizing and complement-fixing antibody to this virus. Although adenovirus type 11 isolates had been obtained from 2 of 18 renal allograft recipients, only 1 patient suffered acute hemorrhagic cystitis. Adenovirus type 11 may play a role in acute hemorrhagic cystitis in renal allograft recipients during immunosuppressive therapy.

Acute Disease↗
PubMed1986

[A case of ischias as a complication of internal iliac artery embolization].

A case of severe right radicular ischias following embolization is reported. Gelfoam powder and pledgets were used for right internal iliac artery embolization in the case of intractable bladder cancer hemorrhage. It is supposed that previous radiotherapy and fine embolic material may be the contributing factors to this complication.

Embolization, Therapeutic↗
PubMed1985

[A case of spontaneous rupture of renal cell carcinoma].

A case of spontaneous rupture of renal cell carcinoma is reported. A 53-year old man was admitted with the chief complaint of sudden gross hematuria and right flank pain on December 28, 1979. On the following day, the clinical impression was right ruptured kidney, and therefore right nephrectomy was done. Pathological diagnosis was renal cell carcinoma. He received the post-operative irradiation of a total of 5,000 rads. He was seen five years later, at which time there was no evidence of local recurrence or distant metastasis of cancer. Thirty three cases of spontaneous rupture of renal cell carcinoma were collected from Japanese and English literature. Most common chief complaint is abdominal or flank pain. Excretory urography, ultrasonography, CT scan and angiography are useful, but it is difficult to diagnose preoperatively when the tumor is small. Therefore, it is important to suspect occult cancer when a reasonable cause of rupture is undetermined. In these indeterminate cases primary nephrectomy should be considered strongly.

Carcinoma, Renal Cell↗
PubMed1984

[A case of fibroma of the spermatic cord].

A case of fibroma of the spermatic cord is presented. A 26-year-old man was admitted with the complaint of a painless swelling in the left scrotum. On physical examination, the tumor seemed to be in the left spermatic cord. It was removed surgically on May 2, 1983. Microscopic examination of the specimen revealed that the tumor was composed of collagen fibers and fibroblasts. This histological finding was compatible with that of fibroma. Seven cases of fibroma of the spermatic cord so far reported in Japan, including this case, were reviewed.

Adult↗
PubMed1984

[Carcinoma of the urachus--report of 4 cases].

Four cases of urachal carcinoma are presented. The first case was a 36-year-old man who was admitted with the chief complaint of macrohematuria with mucinous debris. Cystoscopic examination revealed a single tumor at the dome of the bladder. Partial cystectomy and postoperative radiation therapy were performed. Histological findings showed a well differentiated adenocarcinoma. He has been well for twelve years postoperatively. The second case was a 52-year-old man who was admitted with the chief complaint of macrohematuria with mucinous debris. Cystoscopic examination revealed a single tumor at the dome of the bladder. Partial cystectomy and postoperative radiochemotherapy were performed. Histological findings showed a moderately differentiated adenocarcinoma. He died of a recurrent tumor 30 months after operation. The third case was 70-year-old man who was admitted with the chief complaint of macrohematuria with mucinous debris. Cystoscopic examination revealed multiple tumors at the dome of the bladder, internal urethral orifice and right lateral wall. Total cystectomy, ureterocutaneostomy and postoperative chemotherapy were performed. Histological findings showed a poorly differentiated adenocarcinoma. He died of a recurrent tumor 30 months after operation. The fourth case was a 68-year-old woman who was admitted with the chief complaint of macrohematuria with mucinous debris. Cystoscopic examination revealed a single tumor at the dome of the bladder. CT scan demonstrated a mass with calcification extending from the bladder dome superiorly. Partial cystectomy and postoperative chemotherapy were performed. Histological findings showed a well differentiated adenocarcinoma. She has been well for three months postoperatively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗