Biomedical subjects

T Koeda

Publications and source records attributed to T Koeda.

At least 37 records · Page 2Linked to original sources

PubMed1998

Successful treatment of progressive myoclonus epilepsy with TRH.

Thyrotropin-releasing hormone (TRH) is sometimes used for the treatment of neurologic disorders such as intractable epilepsy and spinocerebellar degeneration. A 14-year-old girl with progressive myoclonus epilepsy was treated with intravenous TRH for 12 months. Clinical symptoms, such as cortical myoclonus and cerebellar signs, were improved, and P25-N33 amplitudes of somatosensory-evoked potentials decreased after TRH therapy. P100 amplitudes on flash visual-evoked potentials and photosensitivity on electroencephalograms also decreased but only temporarily. Changes in neurophysiologic findings after TRH therapy indicate that TRH inhibits hyperexcitability in the sensorimotor cortex and the visual cortex. Therefore, intravenous TRH therapy is recommended as an alternative therapy in the treatment of progressive myoclonus epilepsy.

Adolescent↗

PubMed1998

Epidemiology of spina bifida in Tottori Prefecture, Japan, 1976-1995.

The authors studied the epidemiology of spina bifida in Tottori Prefecture, Japan, from 1976 to 1995. Thirty-four patients (16 men and 18 women) were registered in this study. Consanguineous marriages, familial occurrence, and abnormalities in prenatal history were not observed. The incidence rate in the entire prefecture and in the eastern, central, and western regions was 0.234, 0.148, 0.425, and 0.230 per 1,000 live births, respectively. The incidence rate in the central region was greater than that in the eastern region with statistical significance (P < 0.05), but the cause of the cluster is unknown. The incidence rate of 0.234 per 1,000 live births for 20 years is compatible with the previous two studies of 1922-1940 and 1948-1954 in Japan. Such apparently stable trends suggest that environmental factors have affected the Japanese less than genetic factors. Seasonal variations are not demonstrated.

Demography↗

PubMed1998

Immunohistochemical detection for Actinomyces sp. in swine tonsillar abscess and granulomatous mastitis.

The tonsils of eleven pigs and the mammary glands of a sow were used to investigate actinomycotic lesions due to Actinomyces sp. infection. At necropsy, there was no abnormality on these tonsils, on the other hand, numerous abscesses containing sulfur granules were found in the mammary. Histopathologically, the Actinomyces sp. lesions were noted as crypt abscesses in the tonsils and as pus-forming granulomas in the mammary glands. The microorganisms in both lesions were composed of bead-like cocci, bacillary cells and short, branching filaments, those cells being positive by the Gram's and Grocott's methods. Clubs were formed around the microbial clumps in these lesions. Immunohistochemically, there were cross-reactions between antibodies of Actinomyces sp. Chiba 101 (101) and swine actinomycetes of 7 species: A. bovis, A. hyovaginalis, A. israeli, A. naeslundii, A. pyogenes, A. suis) formerly Eubacterium suits) and A. viscosus. However it was possible to differentiate Actinomyces sp. 101 from them by absorption and dilution of the antiserum, then the microorganisms in the tonsillar crypt abscesses and the granulomatous mastitis were labelled with an immunoperoxidase technique using the absorbed Actinomyces sp. 101 antiserum. Thus, these immunolabelling properties are suggestive of the presence of 'A. suis' (Grässer) Franke 1973.

Abscess↗

PubMed1998

Transient extreme spindles in a case of subacute Mycoplasma pneumoniae encephalitis.

We describe a 4-year-old boy with delirium including somnolence, irritability, agitation and visual hallucination, associated with Mycoplasma pneumoniae (MP) encephalitis. The MP encephalitis was diagnosed from increased MP-antibody (> 1:1280). Electroencephalography during sleep revealed continuous 9 Hz fast wave activity over the bilateral frontocentral regions, which was thought to represent extreme spindles. These extreme spindles were in parallel with the degree of delirium. Transient extreme spindles have not previously been reported in MP or other encephalitis.

Child, Preschool↗

PubMed1998

[A case of learning-disabled child with a white matter lesion in the left parietal lobe].

We reported a learning-disabled boy, 7-year-old and right handedness, who was similar to developmental Gerstmann syndrome. Dyscalcuria, right-left disorientation, dysgraphia and finger agnosia were correlated with his sequential disorder which was clearly presented by Kaufman Assessment Battery for Children. In this case, a small infarcted lesion was found in the white matter near the left semioval center on MRI. Hypoperfusion of left parietal lobe was also detected by SPECT. The hemisphere dominant in language was assumed to be on the left side by dichotic listening test. We suggested that left parietal lesion was associated with his higher cortical dysfunction.

Brain Diseases↗

PubMed1998

[Higher cortical dysfunctions in preterm diplegia: how to evaluate and treat for their pedagogical difficulties].

Preterm diplegic children (SD) frequently suffer pedagogical difficulties. They showed visual perceptual impairments and also constructional dyspraxia, neuropsychologically. Multiple regression analysis proved that the constructional dyspraxia was independent from the impairments of visual acuity, stereoacuity, depth perception and visual perception. EEG coherence analysis in SD patients disclosed lower interhemispheric coherence at alpha band frequency in occipital derivations. The lower coherence value may correspond to thinning of posterior body and splenium of corpus callosum in SD patients. A adequate ophthalmological treatments, books with enough space between the lines and three dimensional models to facilitate the image of stereography are recommended.

Audiovisual Aids↗

PubMed1997

EEG coherence changes during finger tapping in acallosal and normal children: a study of inter- and intrahemispheric connectivity.

The EEG inter- and intrahemispheric coherences (ICoh and HCoh) in the theta, alpha and beta bands were studied in an acallosal group (ACCG) of five children and a normal group of 30 sex- and age-matched children (NG) during resting and tapping conditions. Being functionally deficient, tapping in the ACCG was characterized by increased intertap intervals and variability (in right-hand tapping) and by variability together with decreased synchronization (in bimanual tapping). In the ACCG, frontal, central and parietal ICohs were shown to be smaller, while temporal ICohs were larger under all conditions (see also Koeda, T., Knyazeva, M., Jonkman, J., Njiokiktjien, C., De Sonneville, L., Vildavsky, V., 1995. The resting EEG in acallosal children: compensatory left hemisphere mechanisms? Electroencephalogr. Clin. Neurophysiol. 95, 397-407). The effect was most pronounced in the EEG beta band. The sagittal HCohs, including fronto-central, fronto-parietal, and centro-parietal HCohs within both hemispheres, were larger in the ACCG, whereas temporal HCoh (fronto-temporal, centro-temporal, parieto-temporal and occipito-temporal) were smaller, suggesting rearrangement of intracortical activity associated with callosal agenesis. Tapping induced an increase in ICoh and HCoh between frontal, central and parietal areas in the NG, and weak enhancement only in the left temporal HCoh in the ACCG. The beta band, the most reactive band in the NG, was 'silent' in the ACCG, suggesting deviant cortical function during motor activity as well.

Adolescent↗

PubMed1997

Mitochondrial encephalomyopathy with 15915 mutation: clinical report.

A 16-year-old boy with mitochondrial encephalomyopathy had seizures, short stature, muscle weakness, progressive hearing loss, mental retardation, and myoclonus. His cranial computed tomography showed progressive calcification in the basal ganglia and cerebral atrophy. Muscle biopsy revealed many ragged-red fibers with variable cytochrome c oxidase activity and some strongly succinate dehydrogenase-reactive blood vessels. Sequence analysis of the entire mitochondrial DNA revealed a novel point mutation in the tRNA-Thr gene at nucleotide pair 15915. Serum lactate levels were decreased by high-dose coenzyme Q10 (CoQ10) therapy. The spectral power density, a parameter of background activity on electroencephalography, was markedly improved after additional administration of idebenone. After initiation of combined CoQ10 and idebenone therapy, the clinical abnormalities did not progress for 16 months.

Adolescent↗

PubMed1997

Bilateral opercular syndrome caused by perinatal difficulties.

Four patients with pseudobulbar palsy, mental retardation and various degrees of speech disturbance associated with perinatal difficulties are described as having an acquired type of opercular syndrome. There were two patients with fetal bradycardia and three with subarachnoid haemorrhage and neonatal convulsion. Magnetic resonance imaging revealed cortical atrophy in the bilateral opercula with some signal abnormalities in the underlying white matter in common. Single photon emission computed tomography (SPECT) also confirmed the presence of hypoperfusion in the regions. Although the opercular syndrome is a clinical entity with a multitude of underlying pathologies, perinatal difficulties could be an important cause of the acquired type.

Adolescent↗

PubMed1997

Incidence of tonsillar lesions caused by Tonsillophilus suis and Actinomyces sp infection in swine.

The tonsils of ten fattening pigs were compared with those of ten breeding sows to determine the relative incidence of Tonsillophilus suis and Actinomyces sp lesions. Macroscopic observation revealed mildly focal upheavals on the tonsillar mucosal surfaces of two of the breeding sows. In tonsillar slices from both pig groups, tiny nodules containing sulfur granules were found. Histopathologically, the T. suis and Actinomyces sp lesions were noted as tonsillar crypt abscesses in both pig groups, and granulomas due to T. suis were seen in the breeding sows. T. suis showed larger 'club-shaped' structures than Actinomyces sp, characterized as clubs showing a broom-like structure with degenerated central thalli. Breeding sows are known to have a higher incidence of tonsillar T. suis lesions than fattening pigs, and in this study, those fattening pigs showing greater propensity to infection by Actinomyces sp also showed a mixed infection with T. suis that produced the tonsillar crypt abscesses. In addition, it is known that in breeding sows, the T. suis lesion develops from a crypt abscess into a granuloma.

Actinomyces↗

PubMed1997

A novel neurological disorder with progressive CNS calcification, deafness, renal tubular acidosis, and microcytic anemia.

Progressive calcification of the brain and the spinal cord at early infantile onset was observed in two siblings. They showed growth failure, psychomotor deterioration, deafness, vestibular dysfunction, microcytic hypochromic anemia, abnormal ratios of lymphocyte subpopulations, and slightly decreased bicarbonate on blood gas analysis. Distal renal tubular acidosis was demonstrated in one of them. Carbonic anhydrase II activity was normal. This new hereditary disease might have a defect in a molecule that is present in brain, spinal cord, kidney and hematocytes and is involved in H+/HCO3- production or transport.

Acidosis, Renal Tubular↗

PubMed1997

Constructional dyspraxia in preterm diplegia: isolation from visual and visual perceptual impairments.

OBJECTIVE: To evaluate ophthalmological profiles, visual perception and constructional function in preterm children with spastic diplegia (SD) and to clarify their neuropsychological deficits in comparison with a control group. METHODS: Thirty-five SD and 34 control children were investigated for visual acuity, eye position, stereoacuity, depth perception, visual perception, visuo-spatial construction and constructional praxis. Each of the results was compared among the four groups as SD with and without strabismus, and control with and without strabismus. RESULTS: Strabismic SD showed worse visual acuity, worse stereoacuity and worse depth perception than the other groups. Constructional dyspraxia was detected in 94.1% of SD either with or without strabismus, while it was rare in the control group. There was no significant contribution of visual acuity, eye position, stereoacuity or depth perception to constructional dyspraxia by stepwise multiple linear regression analysis. CONCLUSION: Strabismic preterm SD children are at high risk for visual dysfunction. Constructional dyspraxia was frequently found in SD children and may be a dysfunction isolated from ophthalmological and visual perceptual dysfunctions.

Adolescent↗

PubMed1997

[Clinical studies of learning disability. Part III: Prevalence of children with suspected learning disabilities].

The prevalence of children with suspected learning disabilities (LD) was investigated. One thousand and eight-hundred-eighty-nine pupils at ordinary elementary classes were evaluated by class teachers. We defined suspected LD as a condition with normal IQ (not less than 70) and low PRS score (not more than 65). Eighteen children (12 boys, 5 girls, and 1 with sex unknown) were considered as suspected LD with this criterion. The prevalence of suspected LD at elementary schools was 0.95%, the lowest figure as compared to those in previous reports. The suspected LD children were studied for the LD type and school grade. Verbal LD was not found, non-verbal LD was found in 6 children, and mixed type in 11. In the study of their school grades, the third grade suspected LD children were the largest. There was a significant decrease in number at higher school grades.

Age Factors↗

PubMed1997

[Clinical studies of learning disability. Part IV : A prospective study of children with risk factors for learning disability at three year-old screening--clinical examinations in 1995].

We are following children with risk factors for learning disability (LD) at three year-old screening prospectively. In 1995, one child reportedly as normal in 1994 was considered to have a possibility of LD. The complaints of their parents had shifted to underachievement. In several children, their poor social skill in school and family was considered to be more serious in 1995 than in 1994. All children who were clumsy in early childhood showed non-optimal motor co-ordination on minor neurological examinations by Touwen. This suggested that non-temporary neurological impairments led them to LD.

Child↗

PubMed1997

[Theophylline-associated epilepsy with lacuna infarction].

We reported a 9-year-old boy who had complex partial seizure for the first time, 4 years and 7 months after an episode of theophylline--associated convulsive status. An ictal EEG showed abnormal theta wave burst which showed no superficial focus, implying existence of deep focus in the brain. MRI revealed left thalamic infarction and hippocampal sclerosis. We regarded these abnormalities as the sequelae of theophylline-associated convulsive status.

Bronchodilator Agents↗

PubMed1996

Sympathetically induced paradoxical increases of the cutaneous blood flow in chronically inflamed rats.

In adjuvant arthritic (AA) rats, an abnormal responsiveness of nociceptors (C-fibre polymodal receptors) to sympathetic activities, i.e., alpha 2-adrenoceptor mediated activation of C-fibre polymodal receptors (CPRs), has been observed. The present investigations were undertaken to determine if a similar plastic change would occur in the cutaneous vascular system in the rat chronic inflammation model. The vascular responses were measured by a laser-Doppler flowmeter in the hindpaw skin of the AA rats after electrical stimulation of lumbar sympathetic trunk (sympathetic stimulation). In control non-arthritic rats, the sympathetic stimulation caused decrease in blood flow of the skin (SkBF) in all animals tested (n = 7). On the other hand, the sympathetic stimulation in the AA rats caused both increase (n = 15) as well as decrease (n = 11) in SkBF. In contrast to the abnormal responsiveness of CPRs, the intra-arterial injection of noradrenaline caused the expected decrease in SkBF in all animals tested, and in no instances increases in SkBF were observed. To determine whether activation of nitric oxide (NO), which is known to be a potent endogenous vasodilatation substance, was involved in the vasodilating effect to sympathetic stimulation, an inhibitor of NO synthase, NG-monomethyl-L-arginine (L-NMMA), was applied systemically. L-NMMA significantly increased baseline blood pressure in the control and the AA rats, but it did not significantly alter the SkBF in the control or the AA rats after the sympathetic stimulation, suggesting that NO is not a mediator in the vasoactive responses. The results of the current studies showed for the first time that electrical stimulation of the lumbar sympathetic trunk causes vasodilatation in the skin of the AA rats. This abnormal responsiveness of regional SkBF after sympathetic stimulation was not mediated by adrenergic or NO system.

Animals↗

PubMed1996

Congenital chylothorax in a patient with 21 trisomy syndrome.

A female infant with 21 trisomy syndrome associated with congenital chylothorax was reported. She was born at a gestational age of 34 weeks by Cesarean section because of fetal hydrothorax and hydrops fetus, confirmed by ultrasonography at 32 weeks. Emergent resuscitation and immediate thoracentesis were performed soon after birth. After beginning breast feeding, the serous pleural fluid became opalescent and a diagnosis of congenital chylothorax was made. Feeding was changed to medium-chain triglyceride (MCT) feeding and the production of pleural effusion disappeared after thoracentesis was performed several times. Accumulating evidence suggested that MCT feeding and intermittent thoracentesis under echo guide were effective. Some reports on patients, including this one, suggest that there may be more patients with 21 trisomy associated with congenital hydrothorax. Therefore, congenital hydrothorax might be listed as a complication of 21 trisomy.

Chylothorax↗

PubMed1996

[Computed tomography and magnetic resonance imaging of the brain in congenital rubella syndrome].

Nine children with congenital rubella syndrome were examined with respect to the relation between clinical symptoms and the findings of computed tomography (CT, 9/9 cases) and magnetic resonance imaging (MRI, 7/9 cases). All patients had deafness, and three had relatively severe sequelae in the central nervous system (CNS), such as mental retardation (MR), cerebral palsy (CP) or microcephaly. In four patients, dilatation of the lateral ventricles was found by CT; in four patients, low-density areas were noted in the periventricular white matter and/or the subcortical white matter; one patient showed a spotty calcified area in the lenticula. No abnormal findings were found by CT in other three patients. MRI in seven children demonstrated areas of prolonged T1 and T2 relaxation times in the white matter in all of them. In relation to clinical symptoms, five patients without dilatation of the lateral ventricles had no sequelae except deafness. On the other hand, in four patients with dilation of the lateral ventricles, three had MR, CP or microcephaly. This study showed that there was a close relation between the ventricular dilatation and sequelae with in CNS, whereas abnormal intensity areas in the white matter found by MRI were not related well to the sequelae of CNS.

Brain↗