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Biomedical subjects

T Koleska

Publications and source records attributed to T Koleska.

At least 19 recordsLinked to original sources

[Fetal motor activity during pregnancy and labor].

The authors examined by actocardiography a group of 98 women in the third trimester of pregnancy. They evaluated the duration, frequency of different movements and the frequency of FHR accelerations in three groups of pregnant women (normal controls, pregnant women with retarded foetal growth and normal PI and finally women with retarded foetal growth and raised PI values). Progression of intrauterine stress led in the investigated group to a gradual decline of motor activity of the foetus along with a decline of the frequency and ratio of FHR accelerations in the total movements and isolated movements of the head and extremities. Statistical significance was proved in four basic parameters. The authors confirmed the priority of the flowmetric diagnosis as compared with actocardiographic recording of developing foetal stress. In the submitted preliminary communication the authors present data on actocardiographic findings during normal delivery. They revealed in particular a marked coincidence of general foetal movements and uterine contractions.

Female↗

The invasive prenatal diagnosis in perinatal centre.

Three main methods of prenatal diagnosis (Amniocentesis AMC, Chorionic villi sampling CVS and Cordocentesis FBS) have been used in Perinatal Centre of Central Bohemia. The chromosomal abnormalities in a group of 3,098 patients have been detected in 1.4% of fetuses. The inherited disorders were diagnosed using DNA analysis and biochemical examination of amniotic fluid. X-linked diseases in a group of 68 patients in 30.8% of fetuses have been diagnosed and inborn error of metabolism in a group of 29 indicated patients in 17.2% of fetuses were diagnosed. The incidence of fetal losses before 28th week of gestation was 0.4%.

Chromosome Aberrations↗

[Results and complications of intrauterine transfusion in fetuses with and without hydrops].

The group comprises 50 intrauterine transfusions in 15 patients with a severe form of foetal erythroblastosis. The authors describe the results and complications in hydropic and non-hydropic foetuses, diagnosed by ultrasound before transfusion treatment was started. In the group of non-hydropic foetuses the success rate of transfusion treatment was 90.1% and 10 neonates were born with a mean weight of 2030 g. The mean gestation period was 34 weeks. From four hydropic foetuses it proved possible to save only one, the success rate in this group was only 25%. The mean weight of hydropic foetuses was 1650 g and the gestation period at delivery 29 weeks. The rate of Caesarean sections in both groups was as high as 80%. Serious complications included thrombosis of the umbilicus, thromboembolism of the a. axillaris in a hydropic neonate and acute hypoxia of the foetus after transfusion. Four of six serious complications were recorded in hydropic foetuses.

Blood Transfusion, Intrauterine↗

[Actocardiography in obstetrics].

Introduction of ultrasonic techniques made more detailed follow-up of the motor activity of the foetus in its natural environment possible. The objective of the submitted paper is to present actocardiography as a method which makes it possible to visualize differences of motor activity of the foetus, in particular during the third trimester and to map different types of movements. The authors obtained thus objective records in a group of pregnancies which will be suitable for comparison with the motor activity of foetuses with signs of hypoxia, with foetuses with retarded growth or foetuses threatened by other risks. This method can be thus included and used as a method of routine in the spectrum of examinations of imminent foetal stress.

Female↗

[Personal experience with the modified pad-weight test].

Subjective evaluation of urinary incontinence cannot assess the degree of abnormality. Objective assessment of the escape of urine is essential for assessment of the degree of incontinence or for evaluation of the therapeutic results. Therefore a simple standard test was elaborated which can be used for the objective measurement of urinary losses in all patients. The International Continence Society (I.C.S.) recommended in 1983 a one-hour test for objective assessment of escape of urine. The latter assesses the loss of urine by weighing pads or dispers before and after standard activities. The authors tried in their clinical department to assess the significance of a modified 40-minute test in women with urinary incontinence--it was only 44%. They also compared the results of the PWT and Puraclo,max and compared these results with the number of women operated on account of incontinence. In the group of patients with a positive PWT a neg-puraclo,max was recorded in 88.2%. Conversely in patients with a neg-puraclo,max the PWT was positive only in 50%. Surgery was used in neg-puraclo,max in 75% and in positive PWT in 76.6% women. In a negative PWT a neg-puraclo,max was recorded in 65% of the patients of whom 61.5% were operated and two refused operation. In the conclusion the authors emphasize that PWT alone provides only basic objective information on the patient's complaints. The reliability of evaluation of the patient's complaints is increased by complete urodynamic examination.

Female↗

[The atropine test in patients with stress incontinence and their treatment with a combination of diltiazem and oxyphenonium].

The authors applied the Atropine test in 28 patients with the motor type of urgent incontinence in an attempt to establish the prognosis of the success of treatment with parasymthatholytics. Atropine was administered in amounts of 0.01 mg/kg body weight by the i.m. route and after 30 mins. a urodynamic control examination was made. The assumption that a reduced frequency or amplitude of detrusor contractions will occur or that they will disappear in patients, where subsequent treatment with parasympatholytics will be successful, was not confirmed. The patients were subsequently treated by a combination of dilthiazem (Diacordin), 3 X 30 mg by the oral route per day and oxyphenonium (Oxyphenon dupl.) 2 X 10 mg by the oral route per day. After evaluation of the therapeutic results the group was divided into two sub-groups. The first one comprised patients where during the urodynamic check-up examination a drop of the intracystic pressure occurred after Atropine administration. The second group comprised patients where the drop of intracystic pressure did not occur. The therapeutic effect in these groups was evaluated separately. In the course of treatment there was a relatively high percentage of undesirable side-effects of the drugs in 43% of the patients. After the general evaluation of the therapeutic effect when the patients had no complaints or improved markedly in 70.4% there were no marked differences between the sub-groups.

Atropine↗

[Personal experiences with bladder training in the treatment of urge incontinence in the female].

Anamnestic and urodynamical results are evaluated before and after bladder retraining drill (BRD) in women suffering from urge incontinence. A continence rate of 74% was determined 6 to 24 months after BRD. This agrees with dates reported by literature. Urodynamically we obtained an improvement of cystometric parameters (even in parts statistically significant). The values of the urethrocystographic angles and the urinary flow rate have been not changed. We could state that the BRD is a good possibility to realize multistep-therapy of female incontinence.

Female↗