A simple and sensitive identification system for the detection of a broad spectrum of drugs is described. ChemElut extraction tubes were used for isolation of drugs from urine. Specimens were screened by thin-layer chromatography (TLC) and confirmed by gas chromatography/mass spectrometry (GC/MS). Special procedures for buprenorphine, cannabinoids, cocaine, LSD, morphine, phencyclidine, halogenated hydrocarbons, paracetamol, and alcohols were used. This system is useful for screening samples in misuse, impaired driving, poisoning, and other forensic cases. It covers about 300 substances including all potentially abused drugs and their metabolites.

Chromatography, Thin Layer↗

PubMedDate not supplied

Comparison of RapiTest with Emit d.a.u. and GC-MS for the analysis of drugs in urine.

Results obtained with RapiTest THC (One Step delta 9-Tetrahydrocannabinol Test), RapiTest MOP (One Step Morphine Test), RapiTest MET (One Step Methamphetamine Test), and RapiTest COC (One Step Cocaine Test) were compared with the results obtained with Emit d.a.u. and with gas chromatographic-mass spectrometric (GC-MS) methods. In all, 81 urine samples taken from specimens submitted for routine analysis in the Laboratory of Pharmacology and Toxicology were analyzed. Samples were screened with Emit, reanalyzed by RapiTests, and quantitated using GC-MS methods. Both positive and negative urine samples were tested. The results obtained with RapiTests correlated well with the Emit d.a.u. and GC-MS data when operating above the cutoff concentrations specified for these methods. RapiTest MOP was found to have crossreactivity with codeine and ethylmorphine, and RapiTest MET crossreacted with amphetamine.

Cannabinoids↗

PubMedDate not supplied

Methyldopa poisoning. Report of the first published fatal case.

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Adult↗