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Biomedical subjects

T Kosinski

Publications and source records attributed to T Kosinski.

9 recordsLinked to original sources
PubMed2000

Single tooth-by-tooth crowns over Frialit-2 implants.

Optimizing aesthetics in the anterior maxilla can be a challenge because of tissue contouring problems. Dental implants allow for restoration of edentulous areas, thus improving function. Some compromises may result as a result of the necessity of predicting the stability of the replacement restorations. The Frialit-2 dental implant system with the internal hex design provides excellent stability for single-tooth restorations. Aesthetics are maximized using Procera Allceram crowns. This case study describes in detail the following: diagnosing and treatment planning for a challenging trauma case; surgical preparation and placement of two Frialit-2 dental implants in the maxillary left central and lateral incisor areas; primary impression techniques and fabrication of a temporary prosthesis over ProTect abutments; second-phase opening; final impressions; and fabrication of two single crowns.

Adult↗
PubMed1989

Hydroxyapatite-augmented sites as receptors for replacement implants.

Implant failures can arise from a variety of conditions. Damage to the tissue structures at surgical placement, inadvertent stress distribution to the marginal bone, unfavorable arch relationships between the maxilla and mandible, occlusal trauma, inadequate prosthetic design, and improper oral hygiene are but a few of the problems that can result in ultimate damage and loss. The use of hydroxyapatite to restore bone contour and health can allow for replacement of a dental implant reconstruction. This paper will describe the use of porous hydroxyapatite to create proper bone morphology for the placement of IMZ osteointegrated dental implants in an edentulous maxilla and a mandibular distal edentulous area. Both cases are followed from the removal of previously placed blade-type implants to the reconstruction by use of the IMZ osteointegrated system within the hydroxyapatite-contoured ridges.

Aged↗
PubMed1984

The dissociation of the extracellular hemoglobin of Tubifex tubifex at extremes of pH and its reassociation upon return to neutrality.

The dissociation of the extracellular hemoglobin of Tubifex tubifex at alkaline and acid pH, and its reassociation upon return to neutral pH, was investigated using gel filtration, ultracentrifugation, and polyacrylamide gel electrophoresis in sodium dodecyl sulfate (SDS-PAGE). Tubifex hemoglobin dissociated at pH above 8 and below 6; both dissociations appeared to be equilibrium processes. The extent of dissociation increased as the pH moved away from neutrality; although dissociation was virtually complete at pH 11, its extent at acid pH did not exceed 50-60% at pH 4. Ca(II), Mg(II), and Sr(II) cations over the range 1-100 mM decreased the extent of the dissociation only at alkaline pH. The visible absorption spectrum of the oxyhemoglobin remained unaltered in the pH range 4-9. At more extreme pH, it changed with time, altering irreversibly to that of the aquo ferri form. Gel filtration of the hemoglobin at both extremes of pH showed that it dissociated into two heme-containing fragments; one consisting of subunit 1 (Mr approximately 17,000) and the other containing subunits 2, 3, and 4 of the hemoglobin (Mr approximately 60,000). Upon return to neutral pH, the dissociated fragment reassociated to the extent of 50 to 80% to whole hemoglobin molecules. The reassociation decreased with increase in alkaline pH, and with decrease in acid pH to which the hemoglobin had been exposed; it increased in the presence of Ca(II), Sr(II), and Mg(II) only subsequent to dissociation at alkaline pH. The SDS-PAGE patterns, gel-filtration elution volumes, and alpha-helical contents, determined from circular dichroism at 222 nm, of the reassociated whole molecules were identical to those of the native hemoglobin.

Animals↗