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Biomedical subjects

T Krajewski

Publications and source records attributed to T Krajewski.

At least 37 records · Page 2Linked to original sources
PubMed1984

Effects of gamma radiation on pig platelet function.

The effects of gamma radiation (60Co source) on pig platelet aggregation, protein secretion, and malonyldialdehyde (MDA) formation were studied. It was observed that gamma radiation (0.1-1 kGy ) modified platelet function, i.e., inhibited platelet aggregation and secretion with concomitant lipid peroxidation expressed by increased amounts of malonyldialdehyde. MDA production in irradiated platelets was dependent on the dose of gamma radiation.

Animals↗
PubMed1984

The Maryland plan for recruiting psychiatrists into public service.

A joint initiative by the University of Maryland and the Maryland Mental Hygiene Administration succeeded in recruiting 116 university-trained psychiatrists into state employment in a period of 7 years. The program emphasizes the creation of an academic environment in state treatment facilities, integration of university and state residency training programs, part-time faculty status for state psychiatrists, and rapid promotion of talented young psychiatrists to positions of authority. The program has been successfully implemented at no cost to either the university or the state.

Foreign Medical Graduates↗
PubMed1982

Binding of fibrinogen molecules to pig platelets and their membranes.

Following addition of ADP, 125I-labelled fibrinogen binds specifically to pig platelets. This binding is completely inhibited by the unlabelled fibrinogen. Quantitative analysis indicates the presence of 12,400-25,000 molecules of fibrinogen which can be bound with an association constant of 5 . 10(8) M-1 to platelets. Fibrinogen receptors were found to be active in the isolated platelet membranes as well. Quantitative analysis of the saturable binding of fibrinogen to the platelet membranes showed that these receptors react with the same affinity with fibrinogen molecules. In contrast to the intact platelets, the platelet membranes can specifically bind fibrinogen in the absence of ADP. We conclude that a specific receptor for fibrinogen is exposed on the surface as a result of cell damage which is the first step of the platelet membrane isolation.

Adenosine Diphosphate↗
PubMed1982

Psychiatric manpower and public mental health: Maryland's experience.

From July of 1976 through December 1981, 67 psychiatrists who graduated primarily from American medical schools and who had completed university residency training programs were recruited into Maryland's state mental health system. As of 1981, 43 of these psychiatrists still worked in inpatient facilities; they represented 33 per cent of all state hospital psychiatrists in Maryland. The Maryland Mental Hygiene Administration and the University of Maryland have used two general strategies to develop psychiatric manpower and improve employment conditions. They established close linkages between academia and the public sector and demonstrated positive, effective leadership by psychiatrists within the state mental health system.

Attitude of Health Personnel↗
PubMed1980

Chemical structure and properties of duck and goose fibrinogen.

Duck and goose fibrinogen were isolated from fresh pooled plasma by three different methods. To minimize proteolytic activity, epsilon-aminocaproic acid and trasylol were used throughout the preparation procedures. Amino acid composition of fibrinogens and carbohydrate content (hexose, hexosamine, sialic acid) as well as phosphorus were analysed. Intact preparations showed single band on SDS-polyacrylamide gel electrophoresis. After reduction and modification of the thiol groups, the material could be separated by SDS-polyacrylamide gel electrophoresis into four bands corresponding to the gamma, partially degraded A alpha, B beta and intact A alpha chain. Intact polypeptide subunits were separated by ion-exchange chromatography or preparative SDS-polyacrylamide gel electrophoresis and their amino acid compositions were determined. Evidences supporting the view that bird fibrinogen is very sensitive to proteolytic degradation and that a partial degradation of the A alpha chain takes place even when inhibitors are used in all steps of the purification procedures are presented.

Amino Acids↗
PubMed1979

The released proteins from avian thrombocytes.

The effect of aggregating agents on the amounts and nature of released proteins from washed goose and chicken thrombocytes was studied. The released protein material was separated on Sepharose 4B. Protein fractions with low molecular weight were next chromatographed on Sephadex G-200. The released proteins from thrombin aggregated pig platelets were analysed in the same way. It was shown that during aggregation avian thrombocytes release protein material containing a well separated fraction (the major component) which seems to correspond to a platelet specific beta-thromboglobulin.

Animals↗