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Biomedical subjects

T Kryst-Widźgowska

Publications and source records attributed to T Kryst-Widźgowska.

At least 19 recordsLinked to original sources

Primitive neuroectodermal tumor (PNET). A case report.

The authors present a case of relatively rare tumor of the central nervous system (CNS) in a 19-year-old female, who died 18 months after the first manifestation of meningismus, increased intracranial pressure and secondary hydrocephalus. Brain autopsy revealed abundant neoplastic infiltrations, which spread through the subarachnoid space. Neoplastic infiltrations were also present in the third ventricle and in a form of small subependymal nodules along the whole ventricular system. The microscopical examination showed that neoplasm consisted of small cells, which formed neuroblastic Homer Wright rosettes. Immunohistochemical studies (for synaptophysin, chromogranin A, GFAP, vimentin) together with morphology and localization of neoplasm suggested diagnosis of primitive neuroectodermal tumor (PNET) that spread mainly in the leptomeninges and caused obliteration of subarachnoid space.

Adult

Gliomatosis cerebri at the 17-year-old girl--correlations of histological, CT and MRI appearance.

The neuropathologic findings are compared with CT scans and MRI in the case of gliomatosis cerebri; a 17-year-old girl died 2 years after the first epileptic seizure and the onset of neurologic signs. CT scans showed two poorly defined, hypodense foci: the major one in the left parietal white matter and the minor one in the right frontal white matter. MRI demonstrated on T2 weighted image bilateral diffuse increased signal intensity changes with focal high signal mass in the right frontal white matter and cortex as well as in the left occipito-temporal white matter and cortex. The brain coronal sections showed widespread and diffuse neoplastic infiltration in both cerebral hemispheres: corpus callosum, basal ganglia, brainstem and cerebellum. In the microscopic examination diffuse gliomatous infiltration was found.

Adolescent

[Somatosensory evoked potentials in vascular damage to central sensory pathways].

Somatosensory evoked potentials from median nerve (SEP-M) were examined bilaterally in 43 patients with a well delimited vascular foci in central somatosensory pathways. Scalp, far field, cervical, Erb potentials and conduction times were recorded in each patients. Five subgroups based on localization of foci (parietal cortex, corona radiata, internal capsule, thalamus and extensive subcortical--cortical hemispheric focus) were distinguished. The results from the unimpaired (n-38) and impaired (n-48) sides, focus subgroups and control healthy group were statistically compared. The attempt to establish a specific relationship between the SEP-M picture and site of the lesion gave a negative result. SEP-M changes were more pronounced in cases of very extensive axons run in a compact bundle (internal capsule). The SEP-M examination indicates only the degree of the central sensory system damage. Correlations between intensity SEP-M pathology and clinical sensory disturbances were found. SEP-M parameters on the unimpaired side differed significantly from those of the control group. Therefore the impaired side should not be used as a reference for evaluation of impaired side pathology. The diagnostic validity of far field potentials recordings in such investigations is stressed.

Adult

[Changes in NMR and CT images in SSPE].

In 25 patients with subacute sclerosing panencephalitis in various phases of the disease CT and NMR imaging of the brain were done at the same times and the findings were related to clinical symptomatology. NMR imaging, in contrast to CT imaging, demonstrated even very small brain changes in the initial stage. The inflammatory-demyelinizing process begins in SSPE as a rule in the white matter of the occipital lobes, and only later in appears in the vicinity of the anterior horns of the lateral ventricles. Spreading of subcortical changes in the occipital lobes and their later penetration into the parietal lobes causes the development of ideatory apraxia frequent in these cases, and involvement of the cortex of the occipital lobes leads to visual agnosia. The paresis of extremities in later stages not always are correlated with greater intensity of changes in the contralateral cerebral with greater intensity of changes in the contralateral cerebral hemisphere. Hydrocephalus developing after longer duration of the disease is an expression of postinflammatory brain atrophy and not of disturbances in cerebrospinal fluid absorption.

Adolescent

[Scintigraphic and EEG diagnosis of posterior cranial fossa tumors in children].

The purpose of this work was to assess the diagnostic value of scintigraphy and EEG in posterior fossa tumours. The analysis covered 22 children aged from 10 months to 13 years treated surgically in the period from 1975 through 1978 for expanding intracranial lesions of this location. Before the operation in all cases positive ventriculography, brain scintigraphy and EEG were done. In 21 cases ventriculograms were abnormal and scintigrams demonstrated in all these cases presence of pathological foci in the posterior fossa. This method helped in accurate localization of 11 out of 12 tumours of cerebellar hemispheres and 9 of 10 posterior fossa tumours situated near the midline. EEG investigation demonstrated in 7 cases of cerebellar hemisphere tumours presence of asymmetric slow bioelectric activity in the posterior part of the brain on the side corresponding to the tumour. In EEG investigations in cases of midline posterior fossa tumours in most children symmetrical bursts of slow rhythms prevailed in posterior leads showing the characteristics of the so called á distance rhythms.

Adolescent

Dynamic radioisotope study of the internal carotid region of the neck in cerebrovascular disease.

The results of radionuclide angioscintigraphy were evaluated in patients with stricture or occlusion of the extracranial part of the internal carotid artery. Time-activity curves for the first 13 s were generated from left and right internal carotid regions of interest of the neck. The differences between the counts from symmetric regions of interest were measured. We observed decreased activity in regions of interest in cases with stricture of the internal carotid. The first 13 s were significant for evaluation of the extracranial part of the internal carotid.

Arterial Occlusive Diseases

Estimation of the dynamic carotid flow in patients with normal radionuclide cerebral perfusion.

Radioisotope angioscintigraphy following intravenous injection bolus of 99mTc-pertechnetate was performed in 49 patients with cerebrovascular disturbances. The region of interest placement on the sequential analog images of both middle cerebral and internal carotid arteries and time-activity curves were displayed on the video monitor. In 35 cases of this group we have noticed symmetrical cerebral perfusion and a significant difference between right and left internal carotid flow, and in 33 cases of which dynamic studies were made stenosis or occlusion of the extracranial part of the carotid internal artery was revealed by the X-ray angiography.

Carotid Artery, Internal

[Significance of oligoclonal proteins and magnetic resonance imaging in the diagnosis of multiple sclerosis].

The new techniques identifying inactive clinical injury, as well as revealing immunological disturbances connected with the CNS, are very helpful for arriving at the correct diagnosis of multiple sclerosis. In their analysis the authors of the work include six cases and emphasize the great practical significance of magnetic resonance imaging and oligoclonal bands in the cerebrospinal fluid in making the diagnosis of multiple sclerosis.

Adult

[Giant arteriovenous angiomas of the brain with scant clinical manifestations].

Two patients are described with large intracranial arteriovenous angioma with minimal neurological symptoms. The first patient suffered from repeated right fronto-temporal headache. Migraine was diagnosed and he was treated with analgesic drugs. We carried out scintigraphic investigation and computerized tomography of the brain. The results of these examinations suggested the presence of large brain lesion (tumour or vascular malformation). Bilateral carotid angiography and aortic arch angiography were done in this patient. A large arteriovenous angioma was discovered in the right occipital area. The second patient complained of throbbing headaches. A bruit could be heard over the left eye which was exophthalmic. Angiograms showed a carotid-cavernous fistula on the left side and a large angioma in the fronto-parietal area. The angioma was clinically "silent". It diminished the symptoms of the carotid-cavernous fistula through the uptake of blood. Both patients were regarded as unsuitable for surgery. The reasons were the great dimension of these angiomas and a large number of supplying arteries.

Adult

[Two cases of ophthalmic zoster follow by hemiplegia].

Two cases of ophthalmic zoster are reported in which several weeks after the appearance of skin changes hemiplegia developed. In one case the clinical course was unfavourable, and on autopsy extensive vasculitis was found in the brain with ischaemic foci situated mainly on the side of zoster. In the second case with favourable outcome CT demonstrated ischaemic foci probably of vascular origin, again on the side of zoster.

Aged