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Biomedical subjects

T Kufaas

Publications and source records attributed to T Kufaas.

16 recordsLinked to original sources

[Laparoscopic examination of non-palpable testis].

BACKGROUND: Approximately 20% of undescended testes are impalpable. They can be located intraabdominally, in the inguinal canal, in ectopic position, or they can be missing. Traditionally, surgical groin exploration has been carried out in such cases, sometimes followed by laparotomy if no testis or spermatic cord could be found in the groin. This approach often involves unnecessary and sometimes too extensive surgery. Laparoscopy facilitates the identification of the testicle or proves the lack of it in a less invasive way. MATERIAL AND METHODS: From 1986 to 1999, 77 boys aged one year five months to 13 years 7 months underwent laparoscopy for unilateral or bilateral nonpalpable testis in our department. RESULTS: In 72 boys (94%), the findings were conclusive in the form of intraabdominal testis in 26, an intact intraabdominal spermatic cord entering the deep inguinal ring in 27, and a missing testis in 19 boys. INTERPRETATION: Laparoscopy identified the boys who did not require further surgery because the testis was missing, Furthermore, when a testis was found, laparoscopy was helpful in choosing the most appropriate method of orchiopexy. It is concluded that at present, laparoscopy is the preferred method of investigation in boys older than one year of age with nonpalpable testis.

Adolescent↗

[Multiple injuries in children].

Multiple injuries do not occur very often in children, but are important because children's general reaction to trauma is different from that of adults. This is due to the anatomic and physiological differences between children and adults, and because some injuries in children differ considerably from similar injuries in adults. It is important to know these facts, even if the methods used for resuscitation and immediate follow-up are much the same in children as in adults. A special type of injury that is seen with increasing frequency comprises the bizarre injuries caused by child abuse.

Age Factors↗

Congenital diaphragmatic hernia: determination of the optimal time for operation by echocardiographic monitoring of the pulmonary arterial pressure.

Preoperative stabilization and delayed operation rather than emergency repair of congenital diaphragmatic hernia (CDH) may improve survival, but there are no clear criteria for how long operation should be delayed. Because increased pulmonary vascular resistance (PVR) may be an important risk factor, we used Doppler echocardiography to study patients with CDH presenting with respiratory distress immediately after birth. During the study period 10 patients were admitted, but 2 were moribund on admission and died shortly thereafter. In the remaining patients the pulmonary arterial pressure (PAP) and direction of ductal shunt were estimated by Doppler echocardiography. Initial PAPs were in the range of 45 to 90 mm Hg, with bidirectional or right-to-left shunt through the ductus arteriosus. Reduction of pressure to 25 to 55 mm Hg, or reversal of shunt to left-to-right, reflecting decreased PVR, occurred after ventilation for 3 to 20 days (mean, 8 days). Patients underwent operation after there was evidence of reduced PVR. None developed persistent fetal circulation, and all 8 patients survived. We conclude that postponing operation until PVR has decreased seems to improve survival in patients with CDH presenting within hours of birth.

Blood Pressure↗

Pharmacokinetics of intravenous cefetamet and oral cefetamet pivoxil in children.

The pharmacokinetics of cefetamet were determined after intravenous (i.v.) administration of cefetamet and oral administration of cefetamet pivoxil syrup to patients between the ages of 3 and 12 years. The patients were hospitalized for reconstructive urological surgery; to prevent infection, prophylactic i.v. cefetamet was administered on the day of surgery and oral cefetamet pivoxil was administered 2 days later. After i.v. administration, the mean (+/- standard deviation) half-life of cefetamet was 1.97 +/- 0.60 h (n = 18), which was different from the 2.46 +/- 0.33 h reported for nine adults (22 to 68 years old) in a previous study. The average values for the mean residence times were 2.35 +/- 0.94 and 2.83 +/- 0.34 h and the average values for the fraction of the dose eliminated unchanged in the urine were 79.9% +/- 8.99% and 80% +/- 11% in children and adults, respectively. Plots of mean systemic clearance and steady-state volume of distribution versus body weight for the children and comparative adults were linear on log-log coordinates, and the slopes of the plots were 0.661 and 0.880, respectively. These slope values suggested that mean systemic clearance values per unit of body surface area were similar in children and adults and that maintenance doses for children should be the adult maintenance dose multiplied by the child's surface area divided by 1.73 m2. The mean (+/- standard deviation) oral bioavailabilities of cefetamet pivoxil were 49.3% +/- 15.7% in 3- to 7-year-old children who received a 500-mg dose and 37.9% +/- 10.0% in 8- to 12-year-old children who received a 1,000-mg dose. These values were not different from that observed in the adult group after two 500-mg tablets. Likewise, the peak concentration of cefetamet in plasma and its time of occurrence in children were in line with the values which have been observed for adults.

Administration, Oral↗

Free periosteal grafts in tracheal reconstruction: an experimental study.

If resection followed by end-to-end anastomosis is not possible in obstructive lesions of the trachea other methods of reconstruction must be used. The ability of a periosteal graft to induce bone or cartilage formation when transplanted to cover a tracheal defect was confirmed in a previous experimental study. In this study free tibial periosteal grafts were used for repair of tracheal defects created in rabbits. The graft was placed circumferentially around the trachea. It is concluded that there is a high risk of development of severe osseous tracheal stenosis when periosteal grafts are placed circumferentially around the trachea.

Animals↗

Wilms' tumour in a horseshoe kidney. Diagnostic difficulties.

A case of Wilms' tumour in a horseshoe kidney is presented. Until 1980, twenty-one cases were reported. Diagnosis may be difficult, especially as x-ray investigations, including IVP and renal angiograms, give the impression of a tumour arising outside the kidney. The distortion and dispersion of the renal pelvis and calyces usually seen with a Wilms' tumour are lacking. This is probably due to the special anatomic pattern of the horseshoe kidney, specifically the rotation of the renal pelvis around the long axis of the kidney.

Female↗

Acute circulatory insufficiency of previously operated testes.

Conditions leading to circulatory disturbances of the testes following previous fixation after testicular torsion or after orchidopexy for retained testes are reported. Different methods of fixation are discussed, and recommendations as to operative procedures are made.

Adolescent↗

Splenogonadal fusion.

A case of splenogonadal fusion of the discontinuous type in a 7-year-old boy is reported. The literature is reviewed and the common clinical features of the malformation are discussed. The condition should be considered in the differential diagnosis of scrotal tumours.

Abnormalities, Multiple↗