Biomedical subjects

T Kuneva

Publications and source records attributed to T Kuneva.

3 recordsLinked to original sources

PubMed1992

[The interaction between lead, cadmium and essential trace elements (an experimental study)].

An experimental study is performed on 120 white male Wistar rats with average weight 180-210 g. The animals are distributed in 4 groups. I group--control; II group--animals treated with aqua solution of cadmium sulphate; III group--animals treated with aqua solution of cadmium sulphate and lead acetate simultaneously and IV group--animals treated with aqua solution of lead acetate. The toxic substances are introduced per oral in dose 1/40 of LD50 and for a period of 90 days. The animals are killed by decapitation on the 2, 4, 15, 30 and 90th day from the beginning of treatment. An increased content of cadmium in blood, urine and liver is registered in II and III group of animals, and of lead--in III and IV group animals. The zinc content in liver in group II is increased in comparison with the control group, while in group III and IV remains unchanged. The concentration of zinc in blood in animals from II and III group is increased. There is no deviation in group IV. The copper content in liver is decreased in II, III and IV group. There are no significant deviations in the content of copper in the blood of the examined groups of animals. The level of manganese in liver in II, III and IV group of animals is reduced. No changes in the content of manganese in blood are registered in the examined groups animals.

Animals↗

PubMed1992

[Toxic lesions in workers in the pharmaceutical industry].

Clinical studies are performed on 15 workers from the chemical and pharmaceutic plant "Stanke Dimitrov". Seven of the workers are with acute poisoning from aniline and phenylhydrazine, and eight are exposed to a chronic combined effect of a large group of organic solvents. The clinic and laboratory examinations aim at clarifying the liver and kidney functions, the state of the blood and nervous systems. The tests embrace also blood test morphology and osmotic resistance of erythrocytes, iron, correlation of haemoglobin types, electrolytes, transaminase, GGTP, lipid metabolism, iron-binding capacity. Moderately increased transaminase activity is found in 2/3 of the examined. In four of the workers is registered expressed anaemic and lung syndrome. The following diagnoses are accepted: chronic combined effect of organic solvents--in 3 workers; chronic poisoning with aniline and other solvents--in 1; toxic hepatitis--in 4, with no data for poisoning--in 7. The leading clinical syndromes in acute and chronic combined effect of organic solvents are discussed.

Acute Disease↗

PubMed1992

[The incidence of paraprofessional diseases in employees of the Research Institute of Ferrous Metallurgy in Kremikovtsi].

The health status of 200 workers from the Institute for Ferrous Metallurgy is studied in view of the harmful effect of the unfavourable factors of the working environment (noise, microclimate, toxic aerosols, gases and vapours). Internal examinations are also performed. A number of laboratory indices are determined in order to assess the liver and kidney functions. A complete blood test and lipid metabolism are examined. Lead and manganese are determined in blood by atomic-absorption spectrophotometry. In 23.5% of the examined are established data for arterial hypertension; with diseases of the gastric-intestinal tract are 22%. The influence of the toxic aerosols and the nervous and psychic loading of the examined workers on the higher prevalence of the paraoccupational diseases are discussed.

Academies and Institutes↗