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Biomedical subjects

T Kurimoto

Publications and source records attributed to T Kurimoto.

At least 73 records · Page 4Linked to original sources
PubMed1984

[Antiepileptic effects of globulin-N as an intact human immunoglobulin and its tissue-distribution in kindled cats].

The antiepileptic effects of Globulin-N as an intact human immunoglobulin were examined using the amygdaloid kindled animals, which was prepared by the method of Goddard et al (1969) and Wada et al (1974). In the non-treated kindled cats, generalized convulsion (GC) and after-discharge (AD) in amygdala, hippocampus and neocortex was caused synchronously by electrical stimulation with generalized seizure-triggering threshold (GST) at constant intervals of 24 hours. By contrast, in kindled cats treated intravenously with 200 mg/kg Globulin-N, the GC and AD due to the GST-stimulation disappeared entirely for the period 4 to 8 days after medication in 8 out of 10 cases. Further, kindled cats treated with anticonvulsant, phenobarbital or phenytoin inhibited GC and AD to GST-stimulation until 24-48 hours after medication. On the other hand, the plasma half-life of Globulin-N was determined as about 10 days in the kindled cats, and Globulin-N was distributed immunohistochemically not only in the visceral organ-tissues but also in the tissues of the brain and spinal cord. The administered Globulin-N or 14C-human immunoglobulin pass through the blood-brain barrier easily in kindled cats with GST induced-epileptic seizure, and was apparently taken up by the nerve cells and glial cells in the cerebral cortex and other extensive deep structure involved in the central nervous system. These results seem to support the clinical usefulness of Globulin-N in patients with epilepsy (Ariizumi et al, 1982) and also epileptic psychosis.

Amygdala↗
PubMed1983

Immunoreactive carcinoembryonic antigen in gastric juice in patients with gastric cancer.

To clarify the significance of immunoreactive carcinoembryonic antigen in gastric juice (gastric CEA) from gastric cancer patients, we studied the gastric CEA in comparison with cancer progress, histologic types of tumors, staining for CEA and extent of intestinal metaplasia. The gastric CEA levels from patients with other gastric diseases, i.e., gastric ulcer, duodenal ulcer and chronic gastritis were also investigated. The mean gastric CEA level from gastric cancer patients was significantly higher than from gastric or duodenal ulcer patients, but there was no significant difference between levels in patients with gastric cancer and in those with chronic gastritis. The gastric CEA levels from cancer patients increased with progression of the cancer. The differentiated carcinomas showed significantly higher gastric CEA levels than the poorly differentiated carcinomas. Positive CEA tumors showed significantly higher gastric CEA levels than did the negative CEA tumors. The tumors with diffuse intestinal metaplasia revealed high gastric CEA levels. Determination of gastric CEA levels is considered to be useful for screening of gastric cancer.

Carcinoembryonic Antigen↗
PubMed1983

[Inactivation of aminoglycoside antibiotics by clinically isolated Pseudomonas aeruginosa].

Minimal inhibitory concentrations (MIC) of micronomicin (MCR) and gentamicin (GM) against clinically isolated Pseudomonas aeruginosa F 4150 were 1.56 mcg/ml and 6.25 mcg/ml, respectively. Sisomicin, dibekacin, amikacin, netilmicin, tobramycin ribostamycin and kanamycin did not inhibit the strain at the concentrations less than 25 mcg/ml. Each aminoglycoside antibiotic was incubated in Tris-HCl buffer solutions (pH 7.8) containing cell free crude enzyme preparations obtained by sonic oscillation of intact cells of P. aeruginosa F 4150, coenzyme A and adenosine-5'-triphosphate. The residual activity at 3 hours of incubation at 37 degrees C was 88% for MCR and 33.6% for GM, while all of the other aminoglycoside antibiotics tested were completely inactivated under this condition.

Aminoglycosides↗
PubMed1983

[Combined effects of micronomicin and latamoxefi in vitro synergistic activities].

In vitro synergistic activities of new aminoglycoside antibiotic micronomicin (MCR, Sagamicin) combined with oxacephem antibiotic latamoxef (LMOX, Siomarin) were investigated. These antibiotics exhibited synergistic activities at FIC index lower than 0.5 against 20.8%, 32.7% and 1.9% of clinical isolates of Pseudomonas aeruginosa (48 strains), Serratia marcescens (52 strains) and Escherichia coli (54 strains), respectively. Partial synergism (0.5 less than FIC index less than 1) was observed in 79.2%, 55.8% and 31.5% of the same microorganisms, too. Each bacteriostatic concentrations of MCR and LMOX showed synergistically bactericidal effects when the drugs were administered at the same time against P. aeruginosa BMH No. 1, S. marcescens F-3283 and E. coli GN2411-5.

Aminoglycosides↗
PubMed1983

[Pharmacokinetic studies on micronomicin in rats. Comparison of intramuscular and drip intravenous administration models].

Absorption, tissue distribution and excretion of micronomicin (MCR) were studied in rats after intramuscular or 30 minutes drip intravenous administration (10 mg/kg). Serum levels of MCR were measured by bioassay, enzyme immunoassay and high pressure liquid chromatography. The pharmacokinetic studies of MCR after intramuscular or drip intravenous administration were carried out using one-compartment open model or two-compartment open model, respectively. Among 3 assay methods, similar pharmacokinetic parameters of MCR were obtained. In the simulation of serum levels of MCR, the differences between the measured and calculated serum levels after intramuscular or drip intravenous administration were less than 19% of the former levels. After intramuscular or drip intravenous administration of MCR, similar changes of the organ (kidneys, lungs, spleen and liver) levels were observed. Urinary recovery rates of MCR amounted to 82.3% or 91.6% by 24 hours after intramuscular or drip intravenous administration, respectively. After intramuscular or drip intravenous administration of MCR, no metabolites were found in urine of rats.

Aminoglycosides↗
PubMed1981

[Effect of soedomycin (M3) on the phagocytosis in the mouse (author's transl)].

Effect of M3, an anticancer agent, on the phagocytic activity of the mouse reticuloendothelial system was studied by the carbon clearance method. Lysosomal enzyme activities of peritoneal exudate cells solution (PECs) and peritoneal macrophage (Mp), and morphological changes of Mp were also examined. The K index (phagocytic index) was significantly increased 24 hr after the administration of M3 (250,300 mg/kg, i.p. X 3) as well as that of zymosan (Z: 50 mg/kg, i.p. X 3). The time course on phagocytic activity of Me (300 mg/kg) was also investigated. The index was increased 2, 4, and 96 hr after i.p. administration, but on i.v. administration the index was decreased at 2 and 4 hr, although increased at 72 hr. Microscopically, carbon particles were internalized by Mp of marginal zones between white and red pulp in the spleen, and in the liver, mainly by Kupffer cells. Lysosomal enzyme activities (acid phosphatase and beta-glucuronidase) and cell numbers of PECs were increased as follows: Z greater than M3 greater than Na2HPO4. These enzyme activities in Mp were also increased significantly 72 and 96 hr after i.p. administration. Observing of morphology by Giemsa staining, saline and Na2HPO4 groups showed round monocytes, but in the M3 and Z groups there were enlarged cells with many projections. These results suggest that M3 promotes the phagocytic activity on the reticuloendothelial system in mice and has a stimulatory effect on Mp because of the increase in the lysosomal enzyme activities and morphological changes in the cells.

Acid Phosphatase↗
PubMed1981

[Intracranial hemorrhage caused by metastatic brain tumors (author's transl)].

Metastatic brain tumors are known to produce the symptoms of stroke and intracranial high density areas are demonstrated by CT scan. But exact preoperative diagnosis is sometimes difficult. Recently, we have experienced three cases of metastatic brain tumors which began with the symptoms of vascular accident and were demonstrated as high density area by CT scan. Two of them are metastasis of lung cancer and another, hepatoma. Characteristic CT findings are as follow: 1) atypical location 2) non-homogeneous high density area extending from the margin of the tumor (sometimes ring-like appearance) 3) surrounding massive edema 4) positive contrast enhancement 5) multiple lesions Two of our cases were demonstrated the recurrence by CT scan which was performed at earlier postoperative stage. The dissemination of tumor cells in the hematoma was thought to be the main factor of it. We also discussed the operative procedures and the postoperative care.

Aged↗
PubMed1981

[A case report of superior sagittal sinus thrombosis--evaluation of computed tomographic findings in diagnosis and comprehension of this sinus thrombosis (author's transl)].

A case of superior sagittal sinus thrombosis was reported. A 23-year-old male was admitted to our clinic on August 16, 1978, because of generalized convulsive seizures. he had complained of severe headache and high fever for about 7 days before admission, and on admission he was in slightly drowsy state. At that time, bilateral choked discs and bilateral abducens pareses were found without any other neurological deficit. CT scan on his 1st hospital day revealed only slight compression of the ventricular system without any midline shift. On the 2nd hospital day, he developed sudden left hemiparesis, but his level of consciousness did not deteriorate as that of the previous day, demonstrating clear CSF by lumbar puncture. Right CAG on August 21 revealed delayed circulation, poor-filling of the cortical veins, and narrow superior sagittal sinus showing zigzag shaped margin. CT scan on August 22 showed multiple irregular high dense foci mainly in both parietal lobes and the shift to the left of the ventricular system. Besides, on enhanced CT scan, the so-called "empty triangle" sign was revealed with gyral enhancement. Although an increase of the shift of the ventricular system was demonstrated by the follow-up CT scans, he gradually improved and external decompression was necessitated no longer. He was discharged with slight weakness of the left upper limb after superior sagittal sinus showing good-filling on right CAG performed on September 27 and had been identified. As a result, it was confirmed that in case sinus thrombosis is doubted, follow-up study by CT scan would be significant for the choice of treatments as well as for its diagnosis at its each stage.

Adult↗
PubMed1978

[Ischemic cerebral symptoms after subarachnoid hemorrhage due to aneurysmal rupture (author's transl)].

Among 169 patients treated at our clinic during past six years there were twenty-four cases (14 per cent) in which cerebral ischemic symptoms gradually developed after full recovery from SAH due to aneurysmal rupture. Duration form the aneurysmal rupture to the onset of ischemic symptoms varied from four days to fourteen days (8 days on average). As the initial symptoms hemiparesis and disturbance of consciousness (18 and 14, respectively) were two major symptoms, and those who showed disturbance of consciousness had more grave prognosis than those with hemiparesis. There were no correlations between the initial symptoms and the sites of aneurysm, but the ICA cases had definitely poor prognosis among those who developed ischemic signs after SAH. Those who became symptomatic within 7 days after SAH had poorer prognosis than those who showed initial symptom more than 8 days after SAH. On angiograms which were done shortly after the onset of symptoms, severe and extensive vasospasm was noted in all cases but four in which degree of vasospasm was not so severe and extensive. Operative treatment, when done within 5 days after the onset of ischemic symptoms had poorer results than when done over 6 days. As a conclusion, it is necessary to watch for possible onset of ischemic symptoms, especially in ICA patients, when seen later than four days after SAH. If ischemic symptoms were present and progressive, the operative treatment should be postponed until clinical course turns uphill by intensive treatments.

Adult↗
PubMed1978

[On the surgical treatment of cerebellar infarction (author's transl)].

Recently we have experienced two cases of acute uncomplicated cerebellar infarction which had been surgically treated. Onset of the disease in both cases was an attack of vertigo with nausea and vomiting, followed by the signs of an expanding lesion in the posterior fossa. There were thirty-one surgically treated cases and only six were fatal so far as we have reviewed cases reported in the literature. The clinical pictures of cerebellar vascular accident are typical in most cases and those of cerebellar infarction are similar to those of cerebellar hemorrhage. These two are frequently indistinguishable on the clinical as well as angiographic grounds, however, CT-scan may be of great value in the differential diagnosis. It is important to realize the cerebellar infarction is also a surgical lesion and not to spend valuable time in differentiating cerebellar infarction from cerebellar hemorrhage. Low mortality rate and low morbidity in cerebellar infarction adequately treated surgically confirm importance for early exploration.

Acute Disease↗