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T L Andersen

Publications and source records attributed to T L Andersen.

3 recordsLinked to original sources

DMP3: a dynamic multilayer perceptron construction algorithm.

This paper presents DMP3 (Dynamic Multilayer Perceptron 3), a multilayer perceptron (MLP) constructive training method that constructs MLPs by incrementally adding network elements of varying complexity to the network. DMP3 differs from other MLP construction techniques in several important ways, and the motivation for these differences are given. Information gain rather than error minimization is used to guide the growth of the network, which increases the utility of newly added network elements and decreases the likelihood that a premature dead end in the growth of the network will occur. The generalization performance of DMP3 is compared with that of several other well-known machine learning and neural network learning algorithms on nine real world data sets. Simulation results show that DMP3 performs better (on average) than any of the other algorithms on the data sets tested. The main reasons for this result are discussed in detail.

Algorithms↗

The relationship between the transport of glucose and cations across cell membranes in isolated tissues. XI. The effect of vanadate on 45Ca-efflux and sugar transport in adipose tissue and skeletal muscle.

(1) The effects of vanadate of hexose transport, 45Ca-exchange and (Na+, K+)-contents have been characterized in isolated adipose tissue and skeletal muscles of the rat. (2) In whole epididymal fat pads, vanadate (0.5-5.0 mM) markedly stimulated the uptake of 2-deoxy[14C]glucose as well as the efflux of 3-O-[14C]methylglucose. (3) Within the same concentration range, vanadate induced an early increase in 45Ca-washout from preloaded fat pads. The maximum increases in the fractional losses of 3-O-[14C]methylglucose and 45Ca were significantly correlated (P less than 0.001, r = 0.98). (4) In extensor digitorum longus and soleus muscles, vanadate (0.5-5.0 mM) stimulated the efflux of 3-O-[14C]methylglucose and this effect was preceded by rise in the washout of 45Ca. The maximum increases in the fractional losses pf 3-O-[14C]methylglucose and 45Ca were significantly correlated (P less than 0.005, r = 0.98). (5) In extensor digitorum longus and soleus muscles, vanadate increased K+-contents and decreased Na+ contents. (6) The stimulation of 45Ca-washout presumably reflects an increase in the cytoplasmic Ca2+ level, brought about by an inhibitory effect of vanadate on the Ca2+-sensitive ATPase of the sarcoplasmic or the endoplasmic reticulum. As demonstrated for most other insulin-like agents (Sørensen, S.S., Christensen, F. and Clausen, T. (1980) Biochim. Biophys. Acta 602, 433-445), the stimulating effect of vanadate on glucose transport appears to be associated with or mediated by a rise in the cytoplasmic Ca2+ level.

Adipose Tissue↗