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T L CHRUSCIEL

Publications and source records attributed to T L CHRUSCIEL.

12 recordsLinked to original sources
PubMed1964

SYMPATHOLYTIC DRUGS AND HYPERLIPAEMIA INDUCED IN RATS BY INTRAPERITONEAL INJECTIONS OF SURFACE-ACTIVE AGENT.

Hyperlipaemia and hypercholesterolaemia were induced in white rats by intraperitoneal injections of tyloxapol. Various sympatholytics and adrenolytics, including blocking agents of beta-receptors, were given simultaneously with tyloxapol. Bretylium tosylate prevented the increase in the serum levels of esterified fatty acids and cholesterol caused by tyloxapol. Phentolamine decreased the enhancement by tyloxapol of cholesterol and total lipid concentrations in the serum. Guanethidine and phenoxybenzamine reduced the increase in the concentration of esterified fatty acids, whereas dichloroisoprenaline insignificantly increased the tyloxapol-induced hyperlipaemia. A small dose of pronethalol slightly increased the esterified fatty acid level in tyloxapol-treated animals; a large dose significantly decreased the serum cholesterol concentration.

Bretylium Compounds↗
PubMed1959

Observations on the substrate specificity of aminne oxidases.

A number of compounds have been tested as substrates of, first, the amine oxidases of rabbit and guinea-pig liver and of goat, pig, horse, and dog plasma and, second, the "diamine oxidase" of pig kidney. Of the three xylylenediamines [di(aminomethyl)benzenes]tested, m-xylylenediamine was found to be a substrate of the liver oxidase. All the plasma oxidases tested acted on both m- and o-xylylenediamine. Both 3- and 4-picolylamine (3- and 4-aminomethylpyridine) were readily oxidized by the liver enzymes; all the plasma oxidases tested oxidized 2-, 3-, and 4-picolylamine. 4-Picolylamine was more rapidly oxidized by horse and dog plasma than any other substrate hitherto examined.

Amine Oxidase (Copper-Containing)↗