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Biomedical subjects

T L Chruściel

Publications and source records attributed to T L Chruściel.

At least 19 recordsLinked to original sources
PubMed1982

Cardiovascular effects of nifedipine--a 4-week treatment in preselected patients with coronary disease.

In 24 patients with coronary ischemic disease the cardiovascular effects of 10-mg tablets of nifedipine given three times daily for 28 days was studied with noninvasive techniques before and after standard work load. Five patients did not complete the study because of drug nontolerance and lack of therapeutic effectiveness. In 19 patients nifedipine has been found to produce positive changes in left ventricle contraction parameters without influencing positively the ECG parameters. An increase in heart rate and the ratio of cardiac oxygen demand to general oxygen consumption was observed. The increase in systolic blood pressure after work load during nifedipine therapy contraindicates use of this drug in cardiac patients with arterial hypertension.

Adult↗
PubMed1978

Questions we recognize but cannot formulate.

The individual response to psychotropic drugs, although dose-dependent, is not stable. In some countries the variations in drug response are more pronounced, indicating a higher level of susceptibility of patients. Factors of importance influencing the response to psychotropic drugs may be subdivided into genetic and environmental ones. In research meant to clarify the difference in relation to the geographic, ethnic and socio-cultural differences among nations and individuals of various ethnic origins in their alien communities, consideration must be given to genetic factors and environmental differences in the daily surroundings. The importance of both social and psychological factors should be recognized in the evaluation of effectiveness of pharmacotherapy.

Drug Interactions↗
PubMed1975

Recent progress in the long-term pharmacological research on cannabis.

Rapid increase in our knowledge of acute biological effects of cannabis and its biologically active components is contrasted with the slow rate of progress achieved in the area of effects of long-term use of cannabis in man. Such studies belong to the difficult category of long-term clinical pharmacological studies, that are time-consuming, require large population samples, and considerable expertise of staff. Recently published epidemiological studies on effects of long-term cannabis use, although still not yet conclusive, supply increasing evidence of harmful effects of such use. Recently, the World Health Organization has sponsored several research projects of this nature in countries with easy access to long-term heavy cannabis users.

Cannabis↗